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Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector

Grant number: 17/04138-8
Support Opportunities:Research Projects - Thematic Grants
Duration: March 01, 2018 - February 28, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Jairo Kenupp Bastos
Grantee:Jairo Kenupp Bastos
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
José Maurício Sforcin ; Sergio Ricardo Ambrosio
Associated researchers:Antonio Cardozo dos Santos ; Antônio Eduardo Miller Crotti ; Ariane Leite Rozza ; Carlos Henrique Gomes Martins ; Claudia Helena Pellizzon ; Denise Crispim Tavares Barbosa ; José Maurício Sforcin ; Juliana Issa Hori ; Lizandra Guidi Magalhães ; Luis Alexandre Pedro de Freitas ; Luiz Alberto Beraldo de Moraes ; Márcio Luís Andrade e Silva ; Niege Araçari Jacometti Cardoso Furtado ; Priscyla Daniely Marcato Gaspari ; Raquel Alves dos Santos ; Renato Luis Tame Parreira ; Ricardo Andrade Furtado ; Rodrigo Cassio Sola Veneziani ; Vanessa Leiria Campo ; Vera Lúcia Lanchote ; Vladimir Constantino Gomes Heleno ; Wilson Roberto Cunha
Associated grant(s):24/01482-3 - International Congress On Natural Products Research 2024, AR.EXT
18/05080-6 - Multi-user equipment approved in grant 2017/04138-8 for high pressure semipreparative chromatographic system model LC-20AR, AP.EMU
Associated scholarship(s):23/01436-9 - ANTIBACTERIAL, IMMUNOMODULATORY AND HEALING ACTION OF A STANDARDIZED EXTRACT OF RED PROPOLIS AND BENZOPHENONE-ENRICHED FRACTION: COMPUTATIONAL PREDICTIONS AND DEVELOPMENT OF A TOPICAL PRODUCT FOR TREATING CUTANEOUS INFECTIONS, BP.PD
23/01282-1 - ANTIMICROBIAL POTENTIAL OF OBLONGIFOLIN A ISOLATED FROM BRAZILIAN RED PROPOLIS AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA) AND ITS IMMUNOMODULATORY ACTION ON THP-1 CELLS, BP.IC
22/09801-5 - "Actuation of faveleira propolis in second intention skin healing. A study focusing on dermal fibroblasts", BP.IC
+ associated scholarships 22/01697-4 - Avaliação da atividade antimelanoma da gutiferona e em roedores, BP.IC
20/14639-7 - Immunomodulatory action of propolis on monocytes of pregnant women with preeclampsia and on human umbilical vein endothelial cells (HUVEC), BP.PD
22/00659-1 - In vitro evaluation of the metabolism of the major compounds of Araucaria sp brown propolis, BP.PD
21/11658-3 - Toxicological evaluation of brown propolis in in vitro and in vivo test systems, BP.IC
21/10516-0 - Evaluation of the healing potential of nanoemulsion containing green propolis extract in the treatment of wounds in hyperglycemic rats infected with methicillin-resistant Staphylococcus aureus, BP.IC
21/12338-2 - Analysis of the cellular effects of the standardized red propolis extract on HeLa and SiHa Cervix Cancer cell lines, BP.IC
21/01411-0 - Chemical study of the Caatinga propolis produced by Apis mellifera and re-isolation of red propolis compounds to perform biological tests and develop analytical methods., BP.PD
21/03788-4 - Pharmacokinetics assessments of red propolis prenylated benzophenones, BP.DR
21/01258-8 - Characterization of fibroblasts and endothelial cells activity on wound healing in rats treated topically with red Brazilian propolis, BP.IC
20/12161-2 - Red propolis: development and validation of an analytical method by liquid chromatography coupled to mass spectrometry, BP.MS
19/14496-4 - Determination of the potential of solid lipid nanoparticles containing green propolis rich in artepelin C in vitro and in the topical therapy of wounds diabetic rats infected with methicillin-resistant Staphylococcus aureus, BP.PD
19/25979-6 - Evaluation of anti-inflammatory potential of kaempferide in paw edema and toxicological profile, BP.IC
19/21743-8 - Evaluation of hiperalgesic, anti-inflammatory and toxicological activies of red propolis, BP.IC
19/11700-0 - Evaluation of the antimicrobial and antiparasitic activities of Artepillin C and its derivatives and study of their gas-phase fragmentation reactions using tandem mass spectrometry, BP.DR
19/01697-1 - Phytochemical study and cytotoxic evaluation of the hexanic fraction and isolated compounds from red propolis produced by Apis mellifera L., BP.IC
17/26252-7 - No clinical toxicology studies of red propolis and its botanical source Dalbergia ecastophyllum (L.) Taub., BP.DR
18/25770-7 - In vitro, in vivo and in silico studies of the antineoplastic activity of guttiferone e in melanoma, BP.MS
18/25010-2 - Isolation and identification of green and brown propolis constituents., BP.PD
18/16172-9 - Development and characterization of nanostructured lipid carriers using Brazilian red propolis in photoprotective formulations, BP.MS
18/25108-2 - Study of antibacterial potential and mixed antibiofilm formation of green propolis against multidrug resistant strains, BP.IC
17/08386-6 - Phytochemical study, development of analytical method and biological evaluation of brown propolis produced by Apis mellifera from Morus Alba, BP.DR
18/17402-8 - Effects of the association cisplatin/green propolis ethanolic extract on A549 cell line: a cell death analysis, BP.IC
17/01618-9 - Study of the potential hypocholesterolemic and antioxidant properties of green propolis and the fraction rich in Artepillin C in vitro and in a diet-induced hypercholesterolemia model in guinea pigs (Cavia porcellus), BP.PD
18/13700-4 - HSCCC method development for the isolation and identification of red propolis constituents, BP.PD
18/00979-0 - Analysis of the anti-inflammatory potential of green propolis against formalin-induced nociception, BP.IC
18/09601-0 - Phytochemical study and antimicrobial evaluation of brown propolis produced by Apis mellifera L. from Eucalyptus spp, BP.IC
18/02370-3 - Evaluation of the quimiopreventive potential of the Brazilian propolis red HYDROALCOOLIC extract, BP.MS
18/03476-0 - Biotransformations of baccharin from green propolis using filamentous fungi and bacteria from the intestinal microbiota, BP.MS
18/06675-3 - In vitro and in vivo toxicogenic study of the hydroalcoholic extract of red propolis in mammalian cells, BP.IC - associated scholarships

Abstract

The Brazilian propolis produced by Apis mellifera called green, brown and red have great economic importance, due to their biological activities and export to several countries, such as Japan and China, and production of approximately 200 tons per year. The main botanical origins of Brazilian propolis are: Baccharis dracunculifolia for green propolis; Araucaria sp, Eucalyptus sp and others for brown propolis; and Dalbergia ecastophyllum for the red propolis. In 2005, ANVISA published a technical note on the registration of products containing propolis, as well as the RDC no. 24/2011 authorizing the registration of propolis-based medicines. However, to date none medicine has been registered with ANVISA. There are many gaps to be filled, since ANVISA demands the execution of chemical, analytical, pharmacological and technological studies to guarantee safety, efficacy and quality in the development of new medicines. Thus, it is proposed to carry out complementary steps in phytochemical studies to obtain standardized extracts and compounds to be used in the development of analytical methods; in obtaining semi-synthetic derivatives; in stability and degradation studies; in bioaccessibility, biotransformation, pharmacokinetic and pharmacodynamic studies; in in silico studies to determine chemical structure-activity relationship and docking analyses; in the development of pharmaceutical formulations; in both in vitro and in vivo toxicological studies; in studies of genotoxicity and mutagenicity; in anti-inflammatory, immunomodulatory, antimicrobial, antiparasitic, antiproliferative, healing and gastroprotective assays, among others. The ultimate goal of this proposal is to add value to the Brazilian beekeeping sector. (AU)

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Scientific publications (64)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAGURNIAK, GLAUCIO REGIS; TEIXEIRA PERACA, CARINA DE SOUZA; ORENHA, RENATO PEREIRA; TAME PARREIRA, RENATO LUIS; PIOTROWSKI, MAURICIO JEOMAR. Double-bond elucidation for arsagermene with a tricoordinate germanium center: a theoretical survey. NEW JOURNAL OF CHEMISTRY, v. 43, n. 39, p. 15681-15690, . (11/07623-8, 17/04138-8)
SILVA, THAYNA DE SOUZA; SILVA, JULIA M. B.; BRAUN, GLAUCIA H.; MEJIA, JENNYFER A. A.; CCAPATINTA, GARI V. C.; CONCEICAO SANTOS, MARIO FERREIRA; TANIMOTO, MATHEUS H.; BASTOS, JAIRO K.; PARREIRA, RENATO L. T.; ORENHA, RENATO P.; et al. Green and Red Brazilian Propolis: Antimicrobial Potential and Anti-Virulence against ATCC and Clinically Isolated Multidrug-Resistant Bacteria. CHEMISTRY & BIODIVERSITY, . (19/01697-1, 18/05080-6, 18/13700-4, 17/04138-8)
RIBEIRO, VICTOR PENA; SIMARO, GUILHERME VENANCIO; MEJIA, JENNYFER ANDREA ALDANA; ARRUDA, CAROLINE; BASTOS, JAIRO KENUPP. Anti-inflammatory and Antinociceptive Activities of the Hydroalcoholic Extract and the Volatile Fraction of Southeastern Brazilian Brown Propolis. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 1, p. 59-66, . (17/08386-6, 17/04138-8)
SERAFIM, MARCELA SAYEGH; RODRIGUES, DEBORA MUNHOZ; RIBEIRO, VICTOR PENA; CCANA-CCAPATINTA, GARI VIDAL; GROPPO, MILTON; GOMES MARTINS, CARLOS HENRIQUE; AMBROSIO, SERGIO RICARDO; KENUPP BASTOS, A. N. D. JAIRO. Eucalyptus botryoides' resin and its new 2-O-galloyl-1,6-O-di-trans-p-coumaroyl-beta-D-glycopyranoside compound display good antimicrobial activity. NATURAL PRODUCT RESEARCH, v. N/A, p. 10-pg., . (17/04138-8)
BOEING, THAISE; MEJIA, JENNYFER ANDREA ALDANA; CCANA-CCAPATINTA, GARI VIDAL; MARIOTT, MARIH; DA SILVA, RITA DE CASSIA MELO VILHENA DE ANDRADE FONSECA; DE SOUZA, PRISCILA; MARIANO, LUISA NATHALIA BOLDA; OLIVEIRA, GRAZIELA REGINA; DA ROCHA, ISABELLE MORAES; DA COSTA, GABRIELA ALTINI; et al. The gastroprotective effect of red propolis extract from Northeastern Brazil and the role of its isolated compounds. Journal of Ethnopharmacology, v. 267, . (17/04138-8)
DE L. PAULA, LUCAS A.; CANDIDO, ANA C. B. B.; SANTOS, MARIO F. C.; CAFFREY, CONOR R.; BASTOS, JAIRO K.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. Antiparasitic Properties of Propolis Extracts and Their Compounds. CHEMISTRY & BIODIVERSITY, v. 18, n. 9, . (17/04138-8, 18/50011-2)
ALDANA-MEJIA, JENNYFER A.; CCANA-CCAPATINTA, V, GARI; SQUARISI, IARA S.; NASCIMENTO, SAMUEL; TANIMOTO, MATHEUS H.; RIBEIRO, VICTOR P.; ARRUDA, CAROLINE; NICOLELLA, HELOIZA; ESPERANDIM, TABATA; RIBEIRO, ARTHUR B.; et al. onclinical Toxicological Studies of Brazilian Red Propolis and Its Primary Botanical Source Dalbergia ecastaphyllu. Chemical Research in Toxicology, v. 34, n. 4, p. 1024-1033, . (17/26252-7, 17/04138-8)
PAULA, LUCAS A. DE L.; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. razilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine mode. Parasitology Research, v. 121, n. 2, p. 775-780, . (18/50011-2, 17/04138-8, 18/25010-2, 18/05080-6)
DOS SANTOS, FRANSERGIO F.; MORAIS-URANO, RAQUEL P.; CUNHA, WILSON R.; DE ALMEIDA, SAMARAH G.; CAVALLARI, PEDRO SANDOVAL DOS SANTOS R.; MANUQUIAN, HALLANA A.; PEREIRA, HENRIQUE DE A.; FURTADO, RICARDO; SANTOS, MARIO F. C.; E SILVA, MARCIO L. AMDRADE. A review on the anti-inflammatory activities of Brazilian green, brown and red propolis. JOURNAL OF FOOD BIOCHEMISTRY, v. 46, n. 10, p. 11-pg., . (17/04138-8, 18/25010-2)
ALDANA-MEJIA, JENNYFER ANDREA; DE MIRANDA, ALINE MAYRINK; CCANA-CCAPATINTA, GARI VIDAL; DE ARAUJO, LUCIANA SILVA; RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; NASCIMENTO, SAMUEL; SQUARISI, IARA; ESPERANDIM, TABATA; DE FREITAS, KAROLINE S.; et al. Genotoxicity and toxicological evaluations of Brazilian red propolis oral ingestion in a preclinical rodent model. Journal of Ethnopharmacology, v. 303, p. 12-pg., . (17/04138-8, 17/26252-7)
GUSHIKEN, LUCAS FERNANDO SERGIO; BESERRA, FERNANDO PEREIRA; HUSSNI, MARIA FERNANDA; GONZAGA, MURILO TIRELI; RIBEIRO, VICTOR PENA; DE SOUZA, PATRICIA FERNANDA; CAMPOS, JACQUELINE COSTA LIMA; MASSARO, TAIS NADER CHRYSOSTOMO; HUSSNI, CARLOS ALBERTO; TAKAHIRA, REGINA KIOMI; et al. Beta-caryophyllene as an antioxidant, anti-inflammatory and re-epithelialization activities in a rat skin wound excision model. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2022, p. 21-pg., . (17/04138-8, 11/13630-7, 17/17600-1)
SANTOS, MARIO FERREIRA CONCEICAO; OLIVEIRA, LARISSA COSTA; RIBEIRO, VICTOR PENA; SOARES, MARISI GOMES; MORAE, GABRIEL DE OLIVEIRA ISAC; SARTORI, ALAN GIOVANINI DE OLIVEIRA; ROSALEN, PEDRO LUIZ; BASTOS, JAIRO KENUPP; DE ALENCAR, SEVERINO MATIAS; VENEZIANI, RODRIGO CASSIO SOLA; et al. Isolation of diterpenes from Araucaria sp Brazilian brown propolis and development of a validated high-performance liquid chromatography method for its analysis. JOURNAL OF SEPARATION SCIENCE, v. 44, n. 16, . (17/04138-8, 18/05080-6, 18/25010-2)
GUSHIKEN, LUCAS FERNANDO SERGIO; BESERRA, FERNANDO PEREIRA; BASTOS, JAIRO KENUPP; JACKSON, CHRISTOPHER JOHN; PELLIZZON, CLAUDIA HELENA. Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies. LIFE-BASEL, v. 11, n. 7, . (17/04138-8)
DE OLIVEIRA SARTORI, ALAN GIOVANINI; SPADA, FERNANDA PAPA; RIBEIRO, VICTOR PENA; ROSALEN, PEDRO LUIZ; IKEGAKI, MASAHARU; BASTOS, JAIRO KENUPP; DE ALENCAR, SEVERINO MATIAS. An insight into the botanical origins of propolis from permanent preservation and reforestation areas of southern Brazil. SCIENTIFIC REPORTS, v. 11, n. 1, . (17/04138-8, 19/11248-0)
RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; MEJIA, JENNYFER ANDREA ALDANA; CANDIDO, ANA CAROLINA BOLELA BOVO; DOS SANTOS, RAQUEL ALVES; MAGALHAES, LIZANDRA GUIDI; BASTOS, JAIRO KENUPP. Brazilian southeast brown propolis: gas chromatography method development for its volatile oil analysis, its antimicrobial and leishmanicidal activities evaluation. Phytochemical Analysis, v. 32, n. 3, . (17/04138-8, 17/08386-6)
SON, NINH THE; RIBEIRO, VICTOR PENA; TEIXEIRA, MARIA VALDELINE SOUSA; FURTADO, NIEGE ARACARI JACOMETTI CARDOSO; BASTOS, JAIRO KENUPP. Northeastern Caatinga Green Propolis: Volatile Oil and Antimicrobial Activity. CHEMISTRY OF NATURAL COMPOUNDS, v. N/A, p. 3-pg., . (21/01411-0, 17/04138-8)
SANTIAGO, KARINA BASSO; ZAMAE RODRIGUES, JOAO CARLOS; CARDOSO, ELIZA DE OLIVEIRA; CONTE, FERNANDA LOPES; TASCA, KAREN INGRID; ROMAGNOLI, GRAZIELA GORETE; ALDANA-MEJIA, JENNYFER ANDREA; BASTOS, JAIRO KENUPP; SFORCIN, JOSE MAURICIO. Brazilian red propolis exerts a cytotoxic action against prostate cancer cells and upregulates human monocyte functions. Phytotherapy Research, v. 37, n. 2, p. 11-pg., . (17/04138-8)
SOUSA SILVA, NAGELA BERNADELLI; DE SOUZA, JONATHAN HENRIQUE; SANTIAGO, MARIANA BRENTINI; DA SILVA AGUIAR, JHENNYFER RODRIGUES; SILVA MARTINS, DANIEL OLIVEIRA; DA SILVA, RAFAEL ALVES; SANTOS, IGOR DE ANDRADE; ALDANA-MEJIA, JENNYFER A.; GOMES JARDIM, ANA CAROLINA; PEDROSO, REGINALDO DOS SANTOS; et al. Potential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis. SCIENTIFIC REPORTS, v. 12, n. 1, p. 16-pg., . (17/04138-8)
RIBEIRO, ARTHUR BARCELOS; NICOLELLA, HELOIZA DINIZ; DOMINGOS DA SILVA, LUCAS HENRIQUE; ALDANA MEJIA, JENNYFER ANDREA; TANIMOTO, MATHEUS HIKARU; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; ORENHA, RENATO PEREIRA; TAME PARREIRA, RENATO LUIS; TAVARES, DENISE CRISPIM. Guttiferone E Displays Antineoplastic Activity Against Melanoma Cells. Planta Medica, v. N/A, p. 10-pg., . (18/25770-7, 17/04138-8)
BERNARDES, C. T., V; RIBEIRO, V. P.; DE CARVALHO, T. C.; FURTADO, R. A.; FURTADO, N. A. JACOMETTI CARDOSO; BASTOS, J. K.. Disinfectant activities of extracts and metabolites from Baccharis dracunculifolia DC. Letters in Applied Microbiology, v. N/A, p. 10-pg., . (17/04138-8)
RIBEIRO, VICTOR PENA; ALDANA-MEJIA, JENNYFER ANDREA; ARRUDA, CAROLINE; CANDIDO, ANA CAROLINA BOLELA BOVO; MAGALHAES, LIZANDRA GUIDI; OLIVEIRA, NICOLI DIAS; VENEZIANI, RODRIGO CASSIO SOLA; BASTOS, JAIRO KENUPP; AMBROSIO, SERGIO RICARDO. A RP-HPLC-DAD method for analysis of Brazilian southeast brown propolis and its leishmanicidal properties. BIOMEDICAL CHROMATOGRAPHY, v. 37, n. 8, p. 11-pg., . (22/00659-1, 17/04138-8)
ALDANA-MEJIA, JENNYFER A.; CCANA-CCAPATINTA, GARI, V; SQUARISI, IARA S.; NASCIMENTO, SAMUEL; TANIMOTO, MATHEUS H.; RIBEIRO, VICTOR P.; ARRUDA, CAROLINE; NICOLELLA, HELOIZA; ESPERANDIM, TABATA; RIBEIRO, ARTHUR B.; et al. Nonclinical Toxicological Studies of Brazilian Red Propolis and Its Primary Botanical Source Dalbergia ecastaphyllum. Chemical Research in Toxicology, v. 34, n. 4, p. 10-pg., . (17/04138-8, 17/26252-7)
BESERRA, FERNANDO P.; DE SA FERREIRA, MARCOS V.; CONCEICAO, MARIANA; RODRIGUES, DEBORA M.; ALVES DANTAS, STEFANI T.; MORAES RALL, VERA L.; MARCATO GASPARY, PRISCYLA D.; BASTOS, JAIRO K.; PELLIZZON, CLAUDIA H.. Brazilian Green Propolis-Based Nanostructured System and its use in diabetic rats of Staphylococcus aureus resistant to methicillin (MRSA)-infected wounds. Journal of Pharmacology and Experimental Therapeutics, v. 385, p. 1-pg., . (19/14496-4, 17/04138-8, 21/11550-8)
SANTIAGO, MARIANA B.; LEANDRO, LUIS FERNANDO; ROSA, RAFAEL B.; SILVA, MURILO V.; TEIXEIRA, SAMUEL C.; SERVATO, JOAO PAULO S.; AMBROSIO, SERGIO RICARDO; VENEZIANI, RODRIGO CASSIO S.; ALDANA-MEJIA, JENNYFER A.; BASTOS, JAIRO K.; et al. Brazilian Red Propolis Presents Promising Anti-H. pylori Activity in In Vitro and In Vivo Assays with the Ability to Modulate the Immune Response. Molecules, v. 27, n. 21, p. 14-pg., . (17/04138-8)
CONCEICAO, MARIANA; SERGIO GUSHIKEN, LUCAS FERNANDO; ALDANA-MEJIA, JENNYFER ANDREA; TANIMOTO, MATHEUS HIKARU; DE SA FERREIRA, MARCOS VITAL; MIRANDA ALVES, ANDREIA CRISTINA; MIYASHITA, MARINA NAOMI; BASTOS, JAIRO KENUPP; BESERRA, FERNANDO PEREIRA; PELLIZZON, CLAUDIA HELENA. Histological, Immunohistochemical and Antioxidant Analysis of Skin Wound Healing Influenced by the Topical Application of Brazilian Red Propolis. ANTIOXIDANTS, v. 11, n. 11, p. 20-pg., . (21/01258-8, 17/04138-8)
BESERRA, FERNANDO P.; MARINCEK, ANDREIA; RODRIGUES, DEBORA M.; CALDAS, GABRIEL R.; FERREIRA, IASMIN R. S.; SILVA, LETICIA B.; SCHNEIDER, AYDA H.; DE SA, KEYLA S. G.; GASPARY, PRISCYLA D. M.; BASTOS, JAIRO K.. Brazilian Green Propolis-Based Nanostructured System: Development, Characterization and its Role in the Modulation of Cytokines in In Vitro and In Vivo Experimental Models. FASEB JOURNAL, v. 36, p. 1-pg., . (19/14496-4, 17/04138-8)
RIBEIRO, VICTOR PENA; ALDANA MEJIA, JENNYFER ANDREA; RODRIGUES, DEBORA MUNHOZ; ALVES, GABRIEL ROCHA; PINHEIRO, ANA MARIA DE FREITAS; TANIMOTO, MATHEUS HIKARU; BASTOS, JAIRO KENUPP; AMBROSIO, SERGIO RICARDO. Brazilian Brown Propolis: an Overview About Its Chemical Composition, Botanical Sources, Quality Control, and Pharmacological Properties. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 33, n. 2, p. 12-pg., . (22/00659-1, 17/04138-8)
SARTORI, ARTHUR A.; CARDOSO, ELIZA DE OLIVEIRA; SANTIAGO, KARINA B.; CONTE, FERNANDA LOPES; TASCA, KAREN I.; JUSTINO, ISABELA A.; MARINCEK, ANDREIA; MARCATO, PRISCYLA D.; BASTOS, JAIRO K.; SFORCIN, JOSE M.. Comparing the activity of propolis-loaded nanoparticles or hydroethanolic extract on cytokine production by peripheral blood mononuclear cells. Phytotherapy Research, v. N/A, p. 3-pg., . (17/04138-8)
ZAMARRENHO, LUANA GONCALVES; DE LIMA, MIKHAEL HARUO FERNANDES; HORI, JULIANA ISSA; LIMA, JESSICA APARECIDA; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; DE JONG, DAVID; BERRETTA, ANDRESA APARECIDA. Effects of Three Different Brazilian Green Propolis Extract Formulations on Pro- and Anti-Inflammatory Cytokine Secretion by Macrophages. APPLIED SCIENCES-BASEL, v. 13, n. 10, p. 17-pg., . (17/04138-8)
DO AMARAL, LILIAN; CALDAS, GABRIEL ROCHA; GUINAIM DOS SANTOS, NEIFE APARECIDA; TAME PARREIRA, RENATO LUIS; BASTOS, JAIRO KENNUP; DOS SANTOS, ANTONIO CARDOZO. Baccharin from Brazilian green propolis induces neurotrophic signaling pathways in PC12 cells: potential for axonal and synaptic regeneration. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 395, n. 6, p. 14-pg., . (17/04138-8)
DOMINGOS DA SILVA, LUCAS HENRIQUE; SQUARISI, IARA SILVA; DE FREITAS, KAROLINE SOARES; RIBEIRO, ARTHUR BARCELOS; OZELIN, SAULO DUARTE; ALDANA-MEJIA, JENNYFER ANDREA; SOUZA DE OLIVEIRA, LUCAS TEIXEIRA; RODRIGUES, TABATA ESPERANDIM; SANTOS DE MELO, MATHEUS REIS; NICOLELLA, HELOIZA DINIZ; et al. Toxicological and chemoprevention studies of Dalbergia ecastaphyllum (L.) Taub. stem, the botanical source of Brazilian red propolis. Journal of Pharmacy and Pharmacology, v. 74, n. 5, p. 10-pg., . (17/04138-8)
DE ALMEIDA-JUNIOR, SILVIO; FERRAZ, MATHEUS VITOR FERREIRA; DE OLIVEIRA, ALEX ROBERTO; MANIGLIA, FABIOLA PANSANI; BASTOS, JAIRO KENUPP; FURTADO, RICARDO ANDRADE. Advances in the phytochemical screening and biological potential of propolis. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 37, n. 5, p. 14-pg., . (17/04138-8)
A. DE L. PAULA, LUCAS; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; FALEIROS, RENATA; RAMOS, HENRIQUE P.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. Uncovering Biological Application of Brazilian Green Propolis: A Phenotypic Screening againstSchistosoma mansoni. CHEMISTRY & BIODIVERSITY, v. 17, n. 9, . (17/04138-8, 18/50011-2)
BOEING, THAISE; COSTA, PHILIPE; VENZON, LARISSA; MEURER, MARIANE; BOLDA MARIANO, LUISA NATHALIA; SANTOS FRANCA, TAUANI CAROLINE; GOUVEIA, LUANA; DE BASSI, ANNY CAROLINE; STEIMBACH, VIVIANE; DE SOUZA, PRISCILA; et al. Gastric healing effect ofp-coumaric acid isolated fromBaccharis dracunculifoliaDC on animal model. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 394, n. 1, . (17/04138-8)
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