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Regeneration of bone defects using different therapeutic measures

Grant number: 17/20051-0
Support Opportunities:Regular Research Grants
Duration: February 01, 2018 - July 31, 2020
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Antônio Carlos Shimano
Grantee:Antônio Carlos Shimano
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Aline de Azevedo ; Ana Paula Macedo ; Gabriela Rezende Yanagihara ; Jéssica Suzuki Yamanaka ; João Paulo Mardegan Issa ; Rondinelli Donizetti Herculano


The delay of bone repair can induce deficiencies, incapacities and socioeconomic problems. Thus, strategies of normalization and acceleration of the regeneration process are widely investigated. The aim of the present study is to evaluate the effects of the techniques using bone guided regeneration with membranes based in latex and collagen and fibrin sealant grafting in the consolidation of bone defect in rat tibia. A total of 120 male Wistar rats will be used. Bone healing evaluation will be performed in the animals submitted to surgery procedure to create bilateral bone defect on tibia, then the animals will be assigned into 12 groups according treatment (n=10): TG - treated with Techgraft membrane; ES - treated with synthetic graft; ES+TG - treated with xenograft and Techgraft membrane; LT - treated with látex membrane; COL - treated with collagen membrane; COL+LT - treated with collagen and latex membrane;bTCP - treated with b-trifosfato de cálcio; LT+bTPC - treated with latex membrane covered by b-trifosfato de cálcio; EA - treated with autograft; SF - treated with fibrin sealant; EA+SF - treated with autograft and fibrin sealant; CONT - without treatment. After experimental period, the animals were submitted to euthanasia and bones will be dissected. Bones will be evaluated by morphometric, densitometric, biomechanical, histomorphometric, stereological, immunohistochemical, molecular analysis and finite element method. (AU)

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