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ofF-pump veRsus on-pump coronAry-artery bypass GraftIng in fragiLe patiEnts (FRAGILE)

Abstract

Advances in modern Medicine have led to people living longer and healthier lives. Fragile is an emerging concept in Medicine yet to be explored as a risk factor in cardiac surgery. The optimize surgical myocardial revascularization to all clinical scenarios, compare Off-Pump Coronary Artery Bypass graft (OPCAB) versus on-pump Coronary Artery Bypass Graft (CABG), not yet unveiled. In this context, the randomized, controlled clinical trials so far have primarily focused only on low-risk (ROOBY, CORONARY), elevated-risk (GOPCABE) or high-risk patients (BBS) but not in fragile patients. Medicine advancing a new approach that makes health care more predictive, preventive, participatory, and mainly personalized. Therefore, we believe OPCAB could be an important technique in patients with limited functional capacity to respond to surgical stress. In this study, the authors introduce a national, multicentre, randomized, controlled trial "fragile" to be developed in the main cardiac surgery centers of Brazil, to clarify the potential benefit of OPCAB in fragile patients. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VILCA MEJIA, OMAR ASDRUBAL; BARROS OLIVEIRA SA, MICHEL POMPEU; DEININGER, MAURILIO ONOFRE; PALMA DALLAN, LUIS ROBERTO; SEGALOTE, RODRIGO COELHO; PRACA DE OLIVEIRA, MARCO ANTONIO; ATIK, FERNANDO ANTIBAS; DOS SANTOS, MAGALY ARRAIS; MELO DE BARROS E SILVA, PEDRO GABRIEL; MILANI, RODRIGO MUSSI; HUEB, ALEXANDRE CIAPPINA; MONTEIRO, ROSANGELA; LIMA, RICARDO CARVALHO; FERREIRA LISBOA, LUIZ AUGUSTO; OLIVEIRA DALLAN, LUIS ALBERTO; PUSKAS, JOHN; JATENE, FABIO BISCEGLI. Off-pump versus On-pump Coronary Artery Bypass Grafting in Frail Patients: Study Protocol for the FRAGILE Multicenter Randomized Controlled Trial. Revista Brasileira de Cirurgia Cardiovascular, v. 32, n. 5, p. 428-434, 2017. Web of Science Citations: 4.

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