Advanced search
Start date

Spontaneous Hypothermia And Rewarming In Sepsis (SHARIS)

Grant number: 17/10585-7
Support Opportunities:Regular Research Grants
Duration: December 01, 2017 - November 30, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Francisco Garcia Soriano
Grantee:Francisco Garcia Soriano
Host Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Alexandre Alarcon Steiner ; Dalmo Valerio Machado de Lima ; Felipe Dal Pizzol


Spontaneous hypothermia in septic patients is frequently fought off with active rewarming, but this practice is not evidence-based. Moreover, the need for rewarming patients from hypothermia in this case has been recently questioned by a study showing that septic hypothermia is a transient, self-limiting and non-terminal response. Here, we propose a prospective, interventional trial to assess whether it is unnecessary to use active rewarming to counter spontaneous hypothermia during sepsis. Septic patients that present core temperature of 35.9ºC or less will be enrolled in the study. They will be randomized into two groups: one group will be subjected to active rewarming as soon as hypothermia is detected; the other group will have hypothermia run its natural course (within a safe margin). The primary outcome will be the evolution of SOFA scores over time. As secondary outcomes, we will evaluate thermal comfort and the levels of C-reactive protein and lactate, as well as the incidence of respiratory distress, shock, renal dysfunction, hepatic dysfunction, coagulopathy and cerebral dysfunction. Mortality rate, length of ICU stay and ICU-free days to day 28 will also be assessed. The study does not add risk to the current management of septic hypothermia, since both rewarming and no rewarming are currently used in an arbitrary fashion. The present study is expected to pave the road to an evidence-based guideline for the management of septic hypothermia. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: