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Bioactive surfaces designed from Langmuir-Blodgett Films and Biominerals

Grant number: 17/08892-9
Support Opportunities:Regular Research Grants
Duration: November 01, 2017 - October 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Ana Paula Ramos
Grantee:Ana Paula Ramos
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Pietro Ciancaglini


The synthesis of highly-ordered nanostructured materials that offer specific responses when submitted to an external stimulus is one of the application of nanotechnology. The ability to investigate substances at the molecular level started the search for materials with improved properties to medical applications. The use of these molecularly-controlled materials gave rise to a new research field named nanobiotechnology that has focus in the diagnosis, drug-delivery and implantable materials. The surface chemistry, physics, and thermodynamics, as well as toxicological effects drive the specific application of these materials. The interconnection between these set of properties direct the applications. In this context, different surface modifications can give rise to new materials with distinct biological properties and functionalities to a specific final application, for example to enhance the solubility in the physiological media.In the special case of implantable materials, the surface properties become more important once the success of the application lies in the guest tissue/material interfacial contact. In these materials, the initial cell contact never occurs on a clean surface. The contact occurs on a surface coated with water molecules, ions, and proteins adsorved from the blood-plasma. So, the interaction with water molecules, adsorption of proteins, and cell adhesion are the first events that take place at the tissue/implant interface. The conditioned surface will dictate the cell adhesion and behavior.In the present project, bioactive surfaces (surfaces able to induce the formation of hydroxyapatite when in contact with physiological media) will be synthesized and characterized, focusing in the titanium (the metal most used for bone repair) surface modifications with Langmuir-Blodgett films containing lipids, proteins, and sterols. Moreover, metal oxide (TiO2, ZrO2) nanoparticles and biominerals (CaCO3 and apatites) with different geometries, structuraly modified using cations or anions substituion, and suface-modified by osteogenic proteins adsorption will be tested. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CRUZ, MARCOS A. E.; TOVANI, CAMILA B.; FAVARIN, BRUNO Z.; SOARES, MARIANA P. R.; FUKADA, SANDRA Y.; CIANCAGLINI, PIETRO; RAMOS, ANA P.. Synthesis of Sr-morin complex and its in vitro response: decrease in osteoclast differentiation while sustaining osteoblast mineralization ability. JOURNAL OF MATERIALS CHEMISTRY B, v. 7, n. 5, p. 823-829, . (15/09034-0, 17/08892-9, 14/24249-0, 16/21236-0, 15/08774-0)
TOVANI, C. B.; FARIA, A. N.; CIANCAGLINI, P.; RAMOS, A. P.. Collagen-supported CaCO3 cylindrical particles enhance Ti bioactivity. SURFACE & COATINGS TECHNOLOGY, v. 358, p. 858-864, . (13/12615-0, 17/08892-9, 14/24249-0, 16/21236-0, 12/20946-3)
ANDRADE, MARCO A. R.; DERRADI, RAFAEL; SIMAO, ANA M. S.; MILLAN, JOSE LUIS; RAMOS, ANA P.; CIANCAGLINI, PIETRO; BOLEAN, MAYTE. Is alkaline phosphatase biomimeticaly immobilized on titanium able to propagate the biomineralization process?. Archives of Biochemistry and Biophysics, v. 663, p. 192-198, . (17/08892-9, 16/21236-0, 15/00345-3, 12/20946-3, 14/11941-3)
SPER SIMAO, ANA MARIA; BOLEAN, MAYTE; FAVARIN, BRUNO ZOCCARATTO; VESCHI, EKEVELINY AMABILE; TOVANI, CAMILA BUSSOLA; RAMOS, ANA PAULA; BOTTINI, MASSIMO; BUCHET, RENE; MILLAN, JOSE LUIS; CIANCAGLINI, PIETRO. Lipid microenvironment affects the ability of proteoliposomes harboring TNAP to induce mineralization without nucleators. JOURNAL OF BONE AND MINERAL METABOLISM, v. 37, n. 4, p. 607-613, . (14/11941-3, 16/21236-0, 14/00371-1, 17/08892-9)
TOVANI, CAMILA BUSSOLA; GLOTER, ALEXANDRE; AZAIS, THIERRY; SELMANE, MOHAMED; RAMOS, ANA P.; NASSIF, NADINE. Formation of stable strontium-rich amorphous calcium phosphate: Possible effects on bone mineral. Acta Biomaterialia, v. 92, p. 315-324, . (17/24827-2, 17/08892-9, 14/24249-0)
CRUZ, MARCOS A. E.; FERREIRA, CLAUDIO R.; TOVANI, CAMILA B.; DE OLIVEIRA, FLAVIA A.; BOLEAN, MAYTE; CASELI, LUCIANO; MEBAREK, SAIDA; MILLAN, JOSE LUIS; BUCHET, RENE; BOTTINI, MASSIMO; et al. Phosphatidylserine controls calcium phosphate nucleation and growth on lipid monolayers: A physicochemical understanding of matrix vesicle-driven biomineralization. Journal of Structural Biology, v. 212, n. 2, . (14/24249-0, 17/08892-9, 17/20846-2)
CRUZ, M. A. E.; SOARES, M. P. R.; PAZIN, W.; ITO, A. S.; FUKADA, S. Y.; CIANCAGLINI, P.; RAMOS, A. P.. Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 181, p. 856-863, . (15/08774-0, 17/08892-9, 16/21236-0)
BOLEAN, MAYTE; IZZI, BENEDETTA; VAN KERCKHOVEN, SOETKIN; BOTTINI, MASSIMO; RAMOS, ANA PAULA; MILLAN, JOSE LUIS; HOYLAERTS, MARC F.; CIANCAGLINI, PIETRO. Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1864, n. 8, . (17/08892-9, 14/00371-1, 15/06814-5)
DERRADI, R.; BOLEAN, M.; SIMAO, A. M. S.; CASELI, L.; MILLAN, J. L.; BOTTINI, M.; CIANCAGLINI, P.; RAMOS, A. P.. Cholesterol Regulates the Incorporation and Catalytic Activity of Tissue-Nonspecific Alkaline Phosphatase in DPPC Monolayers. Langmuir, v. 35, n. 47, p. 15232-15241, . (17/08892-9, 15/03594-4, 14/11941-3, 16/21236-0)
TOVANI, CAMILA B.; OLIVEIRA, TAMIRES M.; GLOTER, ALEXANDRE; RAMOS, ANA P.. Sr2+-Substituted CaCO3 Nanorods: Impact on the Structure and Bioactivity. Crystal Growth & Design, v. 18, n. 5, p. 2932-2940, . (17/08892-9, 14/24249-0)
FAVARIN, B. Z.; BOLEAN, M.; RAMOS, A. P.; MAGRINI, A.; ROSATO, N.; MILLAN, J. L.; BOTTINI, M.; COSTA-FILHO, A. J.; CIANCAGLINI, P.. Lipid composition modulates ATP hydrolysis and calcium phosphate mineral propagation by TNAP-harboring proteoliposomes. Archives of Biochemistry and Biophysics, v. 691, . (17/08892-9, 14/00371-1, 18/12092-0, 15/06814-5)
CRUZ, M. A. E.; ZANATTA, M. B. T.; DA VEIGA, M. A. M. S.; CIANCAGLINI, P.; RAMOS, A. P.. Lipid-mediated growth of SrCO3/CaCO3 hybrid films as bioactive coatings for Ti surfaces. Materials Science & Engineering C-Materials for Biological Applications, v. 99, p. 762-769, . (17/08892-9, 16/21236-0, 15/08774-0)
NOGUEIRA, LUCAS F. B.; MANIGLIA, BIANCA C.; BLACIDO, DELIA R. T.; RAMOS, ANA P.. Organic-inorganic collagen/iota-carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration. Journal of Applied Polymer Science, v. 136, n. 39, . (15/21694-6, 17/08892-9, 16/25955-1)
TOVANI, CAMILA B.; OLIVEIRA, TAMIRES M.; SOARES, MARIANA P. R.; NASSIF, NADINE; FUKADA, SANDRA Y.; CIANCAGLINI, PIETRO; GLOTER, ALEXANDRE; RAMOS, ANA P.. Strontium Calcium Phosphate Nanotubes as Bioinspired Building Blocks for Bone Regeneration. ACS APPLIED MATERIALS & INTERFACES, v. 12, n. 39, p. 43422-43434, . (17/08892-9, 14/24249-0, 16/21236-0)

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