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Local allergic rhinitis in children and adolescents

Grant number: 17/03075-2
Support Opportunities:Regular Research Grants
Duration: September 01, 2017 - February 29, 2020
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Gustavo Falbo Wandalsen
Grantee:Gustavo Falbo Wandalsen
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers:Dirceu Solé


Local allergic rhinitis (LAR) is a new phenotype of allergic rhinitis recently described. It is estimated that almost half of patients previously classified as having non allergic rhinitis have LAR. The diagnosis of LAR in patients with rhinitis symptoms and absence of systemic allergic sensitization is done by specific nasal provocation tests (sNPT). The diagnosis of LAR may contribute to the correct pharmacological and non pharmacological management of the disease. Until now no study has studied the prevalence and characteristics of LAR among children and adolescents, and that are the purpose of this study. In order to study LAR we aim to standardized sNPT with Blomia tropicalis (Bt) monitored by acoustic rhinometry in children and adolescents and to define a simplified protocol of provocation. After that, we intend to study the prevalence and the characteristics of LAR in all patients from 6 to 17 years of age with recurrent or persistent nasal symptoms attended in a specialized clinic. Systemic allergic sensitization will be studied by skin prick test and serum specific IgE tests. Simplified sNPT with Dermatophagoides pteronyssinus (already standardized) and Bt will be performed in those without systemic sensitization. Clinical and demographic profile of patients with LAR patients will be compared with those with allergic rhinitis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATSUMOTO, FAUSTO YOSHIO; TRANQUILLINI GONCALVES, TESSA RACHEL; SOLE, DIRCEU; WANDALSEN, GUSTAVO FALBO. Local allergic rhinitis in children: A systematic review. ALLERGOLOGIA ET IMMUNOPATHOLOGIA, v. 50, n. 2, p. 8-pg., . (17/03075-2)

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