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Biocatalytic reactions of aminolysis and kinetic resolution by lipases and biodegradation of agrochemicals by microorganisms

Grant number: 16/20155-7
Support Opportunities:Regular Research Grants
Duration: August 01, 2017 - July 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Andre Luiz Meleiro Porto
Grantee:Andre Luiz Meleiro Porto
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil


In this project enzymatic reactions will be applied in aminolysis and synthesis of halohydrins using commercial enzymes. Also agrochemical biodegradation reactions will be investigated. Biotechnologically the reactions catalyzed by lipases can be used in the synthesis of amides and grease molecules with antioxidant properties, as well as in the preparation of chiral drugs using halohydrins. These reactions are interesting, as they allow their large-scale applications. Also methodologies will be incorporated using immobilization of enzymes and / or application of microwave radiation to obtain better results, such as, reaction times and reuse of biocatalysts. In this project will also be held agrochemical biodegradation reactions with microorganisms (fungi and bacteria), for example, Spirodiclofen and Imidacloprid used as insecticides / acaricides in citrus culture. Thus, this project aims to cover some lines of research that are carried out in the laboratory in biocatalysis, biotransformation and biodegradation reactions using enzymes and microorganisms, and with new applications. (AU)

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Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOSO DE PAULA, SAMUEL FILIPE; ROSSET, ISAC GEORGE; MELEIRO PORTO, ANDRE LUIZ. Hydroxylated steroids in C-7 and C-15 positions from progesterone bio-oxidation by the marine-derived fungus Penicillium oxalicum CBMAI 1996. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 37, . (19/07654-2, 16/20155-7)
BIROLLI, WILLIAN GARCIA; ZANIN, LUCAS LIMA; JIMENEZ, DAVID ESTEBAN QUINTERO; PORTO, ANDRE LUIZ MELEIRO. Synthesis of Knoevenagel Adducts Under Microwave Irradiation and Biocatalytic Ene-Reduction by the Marine-Derived Fungus Cladosporium sp. CBMAI 1237 for the Production of 2-Cyano-3-Phenylpropanamide Derivatives. MARINE BIOTECHNOLOGY, v. 22, n. 2, . (14/18257-0, 16/20155-7)
QUINTERO JIMENEZ, DAVID ESTEBAN; ZANIN, LUCAS LIMA; DINIZ, LUAN FARINELLI; ELLENA, JAVIER; MELEIRO PORTO, ANDRE LUIZ. Green Synthetic Methodology of (E)-2-cyano-3-aryl Selective Knoevenagel Adducts Under Microwave Irradiation. CURRENT MICROWAVE CHEMISTRY, v. 6, n. 1, p. 54-60, . (14/18257-0, 16/20155-7)
DE MATOS, IARA L.; BIROLLI, WILLIAN G.; SANTOS, DARLISSON DE A.; NITSCHKE, MARCIA; PORTO, ANDRE LUIZ M.. Stereoselective reduction of flavanones by marine-derived fungi. MOLECULAR CATALYSIS, v. 513, . (14/18257-0, 16/20155-7)
DE MATOS, IARA LISBOA; NITSCHKE, MARCIA; PORTO, ANDRE LUIZ MELEIRO. B regioselective and chemoselective biotransformation of 2 `-hydroxychalcone derivatives by marine-derived fungi. BIOCATALYSIS AND BIOTRANSFORMATION, . (14/18257-0, 13/21642-0, 16/20155-7)
ANJOS, CHARLENE S.; LIMA, RAFAELY N.; PORTO, ANDRE L. M.. An overview of neonicotinoids: biotransformation and biodegradation by microbiological processes. Environmental Science and Pollution Research, v. 28, n. 28, p. 37082-37109, . (13/21642-0, 16/20155-7)
QUEIROZ, THAYANE M.; OROZCO, ERIKA V. M.; SILVA, VALDENIZIA R.; SANTOS, LUCIANO S.; SOARES, MILENA B. P.; BEZERRA, DANIEL P.; PORTO, ANDRE L. M.. Semi-synthesis of beta-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity. HELIYON, v. 5, n. 9, . (14/18257-0, 16/20155-7)
DE QUEIROZ, THAYANE MELO; ELLENA, JAVIER; PORTO, ANDRE L. M.. Biotransformation of Ethinylestradiol by Whole Cells of Brazilian Marine-Derived FungusPenicillium oxalicumCBMAI 1996. MARINE BIOTECHNOLOGY, . (19/07654-2, 16/20155-7)
FERREIRA, IRLON M.; FIAMINGO, ANDERSON; CAMPANA-FILHO, SERGIO P.; PORTO, ANDRE L. M.. Biotransformation of (E)-2-Methyl-3-Phenylacrylaldehyde Using Mycelia of Penicillium citrinum CBMAI 1186, Both Free and Immobilized on Chitosan. MARINE BIOTECHNOLOGY, v. 22, n. 3, . (14/18257-0, 16/20155-7)
CARDOSO DE PAULA, SAMUEL FILIPE; MELEIRO PORTO, ANDRE LUIZ. Cascate reactions of progesterone by mycelia and culture broth from marine-derived fungus Aspergillus sydowii CBMAI 935. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, v. 25, . (16/20155-7)
GARCIA, ANUSKA C. F. S.; BIROLLI, WILLIAN G.; ARAUJO, BRUNO R.; MARQUES, CARLA G.; BARBOSA-JUNIOR, ANTONIO M.; DINIZ, LEANDRO E. C.; PORTO, ANDRE L. M.; ROMAO, LUCIANE P. C.. Biodegradation of the Polycyclic Aromatic Hydrocarbon Fluoranthene by Fungi Strains from a Brazilian Tropical Peat. Journal of the Brazilian Chemical Society, v. 32, n. 9, p. 1874-1883, . (16/20155-7, 19/07654-2, 17/19721-0)

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