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Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables

Grant number: 16/00006-7
Support type:Research Projects - Thematic Grants
Duration: August 01, 2017 - July 31, 2023
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Rosa Maria Rodrigues Pereira
Grantee:Rosa Maria Rodrigues Pereira
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Vanda Jorgetti
Assoc. researchers:Alexandre da Costa Pereira ; Diogo Souza Domiciano ; Luciene Machado dos Reis ; Nádia Emi Aikawa
Associated grant(s):20/05752-4 - Vitamin D supplementation in patients with COVID-19: randomized, double-blind and placebo controlled clinical trial, AP.R
17/17383-0 - Multi-user equipment approved in grant 16/00006-7: OsteoMeasure - high resolution digital video system, AP.EMU
Associated scholarship(s):22/02638-1 - Evaluation of Bone Metabolism Parameters by HR-pQCT and Histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: Association with Clinical and Genetic Variables, BP.TT
20/14223-5 - Evaluation of Bone Metabolism Parameters by HR-pQCT and Histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: Association with Clinical and Genetic Variables, BP.PD
20/14599-5 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: association with clinical and genetic variables, BP.IC
+ associated scholarships 19/24782-4 - Comparison of mechanisms of bone loss in patients undergoing Roux-en-Y gastric bypass or sleeve gastrectomy, BP.PD
18/01315-9 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis patients: association with clinical and genetic variables, BP.PD
18/07135-2 - Evaluation of Bone Metabolism Parameters by HR-pQCT and Histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: Association with Clinical and Genetic Variables, BP.PD
18/03763-9 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables, BP.TT
18/05596-2 - Evaluation of bone parameters obtained by histomorphometry, HR-pQCT and trabecular bone score in patients with Rheumatoid Arthritis, BP.DD - associated scholarships

Abstract

Rheumatoid Arthritis (RA) is a systemic disease of autoimmune nature, which leads to osteoarticular impairment. Juvenile Idiopathic Arthritis (JIA) is a group of articular disease that affects individuals under 16 years of age. The polyarticular JIA has some peculiarities of RA: symmetrical involvement of small and large joints, bone destruction and disability, if not treated properly. Individuals with RA or JIA are subject to localized bone loss (juxta-articular) and systemic bone loss. In both forms of arthritis, localized bone involvement (erosions) and generalized (osteoporosis) lead to disability and worsening of life quality and increased morbidity and mortality. Risk factors for low bone mass in RA and JIA are multifactorial and include classical risk factors (gender, age, postmenopausal, low calcium intake and low vitamin D and smoking) as well as the intrinsic risk factors (inflammation and disease activity, immobility, and glucocorticoids use). These factors, together with a joint biomechanics changed, increase the risk of fractures. There are no studies in the literature that simultaneously evaluate the localized and generalized bone involvement in RA and JIA patients and genotype-phenotype association in relation to bone and articular involvement. The evaluation of bone involvement by more sensitive and specific cutting-edge methodologies, such as High Resolution peripheral Quantitative Computed Tomography (HR-pQCT), bone histomorphometry and Trabecular Bone Score (TBS) will bring greater prospects for understanding the mechanisms associated with bone involvement in these diseases and help to treat these complications. (AU)

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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JALES NETO, LEVI H.; WICIK, ZOFIA; TORRES, GEORGEA H. F.; TAKAYAMA, LILIAM; CAPARBO, VALERIA F.; LOPES, NEUZA H. M.; PEREIRA, ALEXANDRE C.; PEREIRA, ROSA M. R.. Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community. MOLECULAR GENETICS & GENOMIC MEDICINE, . (16/00006-7)
PEREZ, MARIANA O.; FIGUEIREDO, CAMILLE P.; SALES, LUCAS P.; MEDEIROS-RIBEIRO, ANA CRISTINA; TAKAYAMA, LILIAM; DOMICIANO, DIOGO S.; BONFIGLIOLI, KARINA; CAPARBO, VALERIA F.; PEREIRA, ROSA M. R.. ssociation of Bone Erosions and Osteophytes With Systemic Bone Involvement on High-Resolution Peripheral Quantitative Computed Tomography in Premenopausal Women With Longstanding Rheumatoid Arthriti. ARTHRITIS & RHEUMATOLOGY, v. 74, n. 3, p. 407-417, . (16/00006-7, 18/01315-9, 18/05596-2)
FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; SCHETT, GEORG; PEREIRA, ROSA M. R.. HR-pQCTin vivoimaging of periarticular bone changes in chronic inflammatory diseases: Data from acquisition to impact on treatment indications. MODERN RHEUMATOLOGY, . (16/00006-7, 18/01315-9)
MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; et al. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA, v. 325, n. 11, . (15/26937-4, 20/05752-4, 19/18039-7, 17/13552-2, 20/11102-2, 16/00006-7, 19/24782-4)
NETO, LEVI H. JALES; HOUNKPE, BIDOSSESSI W.; FERNANDES, GEORGEA H.; TAKAYAMA, LILIAM; LOPES, NEUZA H. M.; PEREIRA, ALEXANDRE C.; PEREIRA, ROSA M. R.. Transcriptomic analysis of elderly women with low muscle mass: association with immune system pathway. AGING-US, v. 13, n. 17, p. 20992-21008, . (16/00006-7, 20/14223-5)
FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; MEDEIROS, ANA CRISTINA; CAPARBO, VALERIA F.; PEREIRA, ROSA M. R.. Bone erosion in the 2nd metacarpophalangeal head: association with its bone mineral density by HR-pQCT in rheumatoid arthritis patients. BMC MUSCULOSKELETAL DISORDERS, v. 22, n. 1, . (18/01315-9, 16/00006-7)
PINTO, ANA J.; GOESSLER, KARLA F.; FERNANDES, ALAN L.; MURAI, IGOR H.; SALES, LUCAS P.; REIS, BRUNA Z.; SANTOS, MAYARA DINIZ; ROSCHEL, HAMILTON; PEREIRA, ROSA M. R.; GUALANO, BRUNO. No independent associations between physical activity and clinical outcomes among hospitalized patients with moderate to severe COVID-19. JOURNAL OF SPORT AND HEALTH SCIENCE, v. 10, n. 6, p. 690-696, . (16/00006-7, 20/05752-4, 15/26937-4, 19/18039-7, 19/24782-4, 17/13552-2, 20/11102-2)
MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ASTLEY, CAMILLA; IRAHA, AMANDA YURI; PINTO, ANA JESSICA; MARQUES, ISABELA GOUVEIA; CORDEIRO AMARANTE, MILLA; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; FRANCO, TATHIANE CHRISTINE; et al. Changes in Eating Habits and Sedentary Behavior During the COVID-19 Pandemic in Adolescents With Chronic Conditions. FRONTIERS IN PEDIATRICS, v. 9, . (19/20814-9, 19/14819-8, 19/14820-6, 16/00006-7, 17/13552-2, 19/15231-4, 15/03756-4, 15/26937-4)
ISABELA GOUVEIA MARQUES; CAMILLA ASTLEY; SOFIA MENDES SIECZKOWSKA; AMANDA YURI IRAHA; TATHIANE CHRISTINE FRANCO; FABIANA INFANTE SMAIRA; BRUNA CARUSO MAZZOLANI; LUANA CRISTINA DO AMARAL MIRANDA; BIANCA PIRES IHARA; ROSA MARIA R. PEREIRA; et al. Lessons learned from a home-based exercise program for adolescents with pre-existing chronic diseases during the COVID-19 quarantine in Brazil. Clinics, v. 76, . (15/03756-4, 19/20814-9, 19/15231-4, 16/00006-7, 19/14819-8, 17/13552-2, 19/14820-6)
FIGUEIREDO, CAMILLE PINTO; PEREZ, MARIANA ORTEGA; SALES, LUCAS PEIXOTO; CAPARBO, VALERIA DE FALCO; RODRIGUES PEREIRA, ROSA MARIA. Evaluation of bone erosion in rheumatoid arthritis patients by high-resolution peripheral quantitative computed tomography scans: Comparison between two semi-automated programs in a three-dimensional setting. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. 24, n. 7, . (16/00006-7, 18/01315-9)
REIS, BRUNA Z.; FERNANDES, ALAN L.; SALES, LUCAS P.; SANTOS, MAYARA D.; DOS SANTOS, CAROLINE C.; PINTO, ANA J.; GOESSLER, KARLA F.; FRANCO, ANDRE S.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; et al. Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: a multicenter prospective cohort study. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 114, n. 2, p. 598-604, . (17/13552-2, 15/26937-4, 19/18039-7, 16/00006-7, 20/05752-4, 19/24782-4, 20/11102-2)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.