Advanced search
Start date
Betweenand
Related content

Compounds produced by endophyte microorganisms isolated from Brazilian tropical savannah: bioactivity, association with a-Ag2WO4 and biotechnological applications

Grant number: 16/13423-5
Support Opportunities:Regular Research Grants
Duration: July 01, 2017 - September 30, 2019
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Cristina Paiva de Sousa
Grantee:Cristina Paiva de Sousa
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated researchers:Alberto Colli Badino Junior ; Antonio Gilberto Ferreira ; Fernando Lucas Primo ; Laécio Santos Cavalcante
Associated scholarship(s):17/12905-9 - Bioactive extracts produced by savanna endophytes for alpha-Ag2WO4 associated bioassays, BP.TT

Abstract

The Brazilian tropical savannah is a typical mosaic biome, characterized by endemic and medicinal plants with unique characteristics from where microorganisms can be isolated. Microorganisms are an important source for production of bioactive metabolites for diverse applications. Endophytes are microorganisms that inhabit the interior of plant tissues, without causing apparent disease to its host and they can produce bioactive substances. This project aims to answer three major questions like: a) can bioactive substances derived from endophytes be partially purified and act as antimicrobials? b) can these substances be used to reduce/eliminate chronic and fatal diseases like leishmaniasis? c) can nanoparticles be incorporated with the bioactive endophyte substances or extracts in order to present enhanced results? The importance of this project is linked to the crescent and progressively microbial resistance. In this sense, bioprospection can be used to search for new therapeutic substances that are produced by endophytic microorganisms alone or in association with nanoparticles. Tropical neglected diseases like Leishmaniasis could be treated with the discovery of new substances. Nanotechnology with antimicrobial metal synthesis can be used with synthesized biostatic and/or biocides particles like a-Ag2WO4 and similar. These particles in association with compounds produced by endophytes could enable biotechnological applications. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
TITULO 
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, M. C.; PAIVA DE SOUSA, C.; FERNANDEZ-PRADA, C.; HAREL, J.; DUBREUIL, J. D.; DE SOUZA, E. L.. A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria. Microbial Pathogenesis, v. 130, p. 259-270, . (16/13423-5)
RIBEIRO, LARA K.; ASSIS, MARCELO; LIMA, LAIS R.; COELHO, DYOVANI; GONCALVES, MARIANA O.; PAIVA, ROBERT S.; MORAES, LEONARDO N.; ALMEIDA, LAUANA F.; LIPSKY, FELIPE; SAN-MIGUEL, MIGUEL A.; et al. Bioactive Ag3PO4/Polypropylene Composites for Inactivation of SARS-CoV-2 and Other Important Public Health Pathogens. Journal of Physical Chemistry B, v. 125, n. 38, p. 10866-10875, . (13/07296-2, 16/23891-6, 17/11986-5, 16/13423-5, 17/26105-4, 17/07711-0)
BIANCHI, JAQUELINE; CAVICCHIOLI, RAFAEL; KUBOTA, LAURO T.; CARRILHO, EMANUEL; DE SOUSA, CRISTINA P.; FREITAS ANIBAL, FERNANDA DE. Antigenotoxic potential of the fermentation broth produced by Paenibacillus polymyxa RNC-D in vitro. FUTURE MICROBIOLOGY, v. 16, n. 7, p. 471-485, . (16/13423-5, 14/50867-3)
DA COSTA LIMA, M.; MAGNANI, M.; DOS SANTOS LIMA, M.; DE SOUSA, C. P.; DUBREUIL, J. D.; DE SOUZA, E. L.. Phenolic-rich extracts from acerola, cashew apple and mango by-products cause diverse inhibitory effects and cell damages on enterotoxigenic Escherichia coli. Letters in Applied Microbiology, . (16/13423-5)
A. C. BOGAS; F. P. N. CRUZ; P. T. LACAVA; C. P. SOUSA. Fungos endofíticos: uma visão geral sobre o potencial biotecnológico e agronômico. Brazilian Journal of Biology, v. 84, . (16/13423-5)
DE PAULA NOGUEIRA CRUZ, FELIPE; FERREIRA DE PAULA, AILTON; NOGUEIRA, CAMILA TITA; MARQUES DE ANDRADE, PAULO HENRIQUE; BORGES, LEONARDO MAURICI; LACAVA, PAULO TEIXEIRA; BARATELLA DA CUNHA CAMARGO, ILANA LOPES; ANIBAL, FERNANDA DE FREITAS; PAIVA DE SOUSA, CRISTINA. Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects. INTERNATIONAL JOURNAL OF MICROBIOLOGY, v. 2021, . (13/07600-3, 16/13423-5, 19/04788-8)
MANDUJANO, GUSTAVO P. LORCA; ALVES, HENRIQUE C.; PRADO, CLEITON D.; MARTINS, JEFERSON G. O.; NOVAES, HOSANA R.; MAIA DE OLIVEIRA DA SILVA, JOAO PEDRO; TEIXEIRA, GLEIDSON SILVA; OHARA, ANDRE; ALVES, MATEUS H. R.; PEDRINO, ISADORA C.; et al. dentification and selection of a new Saccharomyces cerevisiae strain isolated from Brazilian ethanol fermentation process for application in beer productio. FOOD MICROBIOLOGY, v. 103, . (16/13423-5, 18/20697-0, 17/12905-9, 19/07505-7, 16/10130-7)
SERRANO, NADJA F. G.; FERREIRA, DOUGLAS; RODRIGUES-FILHO, EDSON; TEIXEIRA, JOSE ANTONIO; DUBREUIL, JEAN DANIEL; DE SOUSA, CRISTINA P.. Purification and characterization of two new antimicrobial molecules produced by an endophytic strain of Paenibacillus polymyxa. Anais da Academia Brasileira de Ciências, v. 93, n. 3, . (16/13423-5)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

MÉTODO PARA BIOSSÍNTESE DE NANOPARTÍCULAS DE OURO POR FITOBACTÉRIAS ENDOFÍTICAS BR1020210083670 - Fundação Universidade Federal de São Carlos (UFSCar) ; Universidade de São Paulo (USP). . CRISTINA PAIVA DE SOUSA (UFSCar) ; CRISTINA KURACHI (USP) e CARINA MIRANDA CARVALHO (UFSCar). - April 2021, 29

COMPÓSITOS DE POLIOLEFINAS E SEMICONDUTORES À BASE DE PRATA COM ALTA ATIVIDADE BIOCIDA BR1020210212632 - Fundação Universidade Federal de São Carlos (UFSCar) ; Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp) ; Universitat Jaume I (Espanha) . LARA KELLY RIBEIRO DA SILVA (UFSCar) ; LAIS RONCALHO LIMA (UFSCar) ; MARCELO DE ASSIS (UFSCar) ; MARIANA OTTAIANO GONÇALVES (UFSCar) ; CRISTINA PAIVA DE SOUSA (UFSCar) ; DYOVANI COELHO (UFSCar) ; LUCIA HELENA MASCARO (UFSCar) ; ELSON LONGO DA SILVA (UFSCar) ; JUAN MANOEL ANDRÉS BORT (Jaime I) ; IEDA LUCIA VIANA ROSA (UFSCar) ; ROBERT DA SILVA PAIVA (UFSCar) ; SANDRA ANDREA CRUZ (UFSCar) ; LEONARDO NAZARIO DE MORAES (UNESP) ; LUANA FOGAÇA DE ALMEIDA (UNESP) e REJANE MARIA TOMMASINI GROTTO (UNESP). - October 2021, 22

PROCESSO DE PREPARO DE UM COMPLEXO DE BASE DE SCHIFF N,N'-BIS(SALICILEDENO)-1,2-FENILENODIAMINA COMPLEXADO COM ÍON METÁLICO, COMPOSIÇÃO FARMACÊUTICA, COMPLEXOS OBTIDOS E USO DO MESMO BR102021024126-8 - Fundação Universidade Federal de São Carlos (UFSCar) ; Universidade Federal de Mato Grosso (UFMT) . CRISTINA PAIVA DE SOUSA (UFSCar) ; THIAGO ANDRADE DE TOLEDO (UFMT) ; BIANCA SORIANO (UFSCar) e GENOVEVA LOURDES FLORES LUNA (UFSCar). - November 2021, 30