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Development of a hydrogel-based delivery system for release of biocompatible glasses ions and drug as support in treatment of bone cancer and subsequent bone regeneration

Abstract

The bone tissue has different functions in the human body, and some diseases may compromise these functions, such as bone cancer, which can also lead to pain and decrease in life quality. In this sense, the patient's life quality may be increased if the treatment of cancer lead to reduction in bone loss and/or bone regeneration. This project aims to develop an injectable delivery system suitable for both local treatment of bone cancer and bone tissue regeneration through brachytherapy and delivery of drug. This system is based on a drug (zoledronic acid) and rare earth-doped biocompatible gasses both trapped in a poloxamer-based hydrogel matrix. The glass will be obtained through sol-gel synthesis, and will be analyzed by X-ray diffraction, scanning electron microscopy, and differential thermal analysis. The glass' potential as source of radiation for brachytherapy will be evaluated by neutron activation. Regarding the systems, first the poloxamer hydrogel matrix will be obtained, being the biocompatible glass and the drug added later, and therefore reaching binary system (poloxamer + biocompatible glass; poloxamer + drug) and ternary systems (poloxamer + biocompatible glass + drug). All these systems will be physical-chemically evaluated by sol-gel transition test (gelation temperature), differential scanning calorimetry, rheology, drug release profile, and determination of drug-micelle partition coefficient. These systems will also be biologically analyzed by cellular viability test, cellular migration teste, cellular metastasis potential, osteogenic differentiation test, and genic expression. At the end, it is expected to obtain a materials with potential properties for bone cancer treatment (AU)

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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BORGES, ROGER; PELOSINE, AGATHA MARIA; DE SOUZA, ANA CAROLINA SANTOS; MACHADO JR, JOEL; JUSTO, GISELLE ZENKER; GAMARRA, LIONEL FERNEL; MARCHI, JULIANA. Bioactive Glasses as Carriers of Cancer-Targeted Drugs: Challenges and Opportunities in Bone Cancer Treatment. MATERIALS, v. 15, n. 24, p. 25-pg., . (20/00329-6, 16/16512-9)
BORGES, ROGER; ZAMBANINI, TELMA; PELOSINE, AGATHA MARIA; JUSTO, GISELLE ZENKER; SOUZA, ANA CAROLINA S.; MACHADO JR, JOEL; SCHNEIDER, JOSE FABIAN; DE ARAUJO, DANIELE R.; MARCHI, JULIANA. A colloidal hydrogel-based drug delivery system overcomes the limitation of combining bisphosphonates with bioactive glasses: in vitro evidence of a potential selective bone cancer treatment allied with bone regeneration. BIOMATERIALS ADVANCES, v. 151, p. 14-pg., . (16/16512-9, 20/00329-6)
ZAMBANINI, TELMA; BORGES, ROGER; FARIA, PAMELA C.; DELPINO, GIULIA P.; PEREIRA, ISIS S.; MARQUES, MARCIA M.; MARCHI, JULIANA. Dissolution, bioactivity behavior, and cytotoxicity of rare earth-containing bioactive glasses (RE = Gd, Yb). International Journal of Applied Ceramic Technology, v. 16, n. 5, SI, p. 2028-2039, . (17/18753-6, 16/16512-9, 11/19924-2)
LEE, ESTER M. R.; BORGES, ROGER; MARCHI, JULIANA; EDUARDO, CARLOS DE PAULA; MARQUES, MARCIA M.. Bioactive glass and high-intensity lasers as a promising treatment for dentin hypersensitivity: An in vitro study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, . (16/16512-9, 11/19924-2)
DE OLIVEIRA, SUELI APARECIDA; BORGES, ROGER; DOS SANTOS ROSA, DERVAL; DE SOUZA, ANA CAROLINA SANTOS; SEABRA, AMEDEA B.; BAINO, FRANCESCO; MARCHI, JULIANA. Strategies for Cancer Treatment Based on Photonic Nanomedicine. MATERIALS, v. 14, n. 6, . (16/16512-9)
ZAMBANINI, TELMA; BORGES, ROGER; DE SOUZA, ANA C. S.; JUSTO, GISELLE Z.; MACHADO, JR., JOEL; DE ARAUJO, DANIELE R.; MARCHI, JULIANA. Holmium-Containing Bioactive Glasses Dispersed in Poloxamer 407 Hydrogel as a Theragenerative Composite for Bone Cancer Treatment. MATERIALS, v. 14, n. 6, . (16/16512-9)
BORGES, ROGER; FERREIRA, LETICIE M.; RETTORI, CARLOS; LOURENCO, ISABELLA M.; SEABRA, AMEDEA B.; MUELLER, FRANK A.; FERRAZ, EMANUELA PRADO; MARQUES, MARCIA M.; MIOLA, MARTA; BAINO, FRANCESCO; et al. Superparamagnetic and highly bioactive SPIONS/bioactive glass nanocomposite and its potential application in magnetic hyperthermia. BIOMATERIALS ADVANCES, v. 135, p. 15-pg., . (20/00329-6, 11/19924-2, 16/16512-9)
ZAMBANINI, TELMA; BORGES, ROGER; FARIA, PAMELA C.; DELPINO, GIULIA P.; PEREIRA, ISIS S.; MARQUES, MARCIA M.; MARCHI, JULIANA. Dissolution, bioactivity behavior, and cytotoxicity of rare earth-containing bioactive glasses (RE = Gd, Yb). International Journal of Applied Ceramic Technology, v. 16, n. 5, p. 12-pg., . (17/18753-6, 16/16512-9, 11/19924-2)
BORGES, ROGER; KAI, KAREN C.; LIMA, CASSIO A.; ZEZELL, DENISE M.; DE ARAUJO, DANIELE R.; MARCHI, JULIANA. Bioactive glass/poloxamer 407 hydrogel composite as a drug delivery system: The interplay between glass dissolution and drug release kinetics. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 206, . (20/00329-6, 16/16512-9)
LEE, ESTER M. R.; BORGES, ROGER; MARCHI, JULIANA; EDUARDO, CARLOS DE PAULA; MARQUES, MARCIA M.. Bioactive glass and high-intensity lasers as a promising treatment for dentin hypersensitivity: An in vitro study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 108, n. 3, p. 939-947, . (16/16512-9, 11/19924-2)
BORGES, ROGER; MENDONCA-FERREIRA, LETICIE; RETTORI, CARLOS; PEREIRA, ISIS S. O.; BAINO, FRANCESCO; MARCHI, JULIANA. New sol-gel-derived magnetic bioactive glass-ceramics containing superparamagnetic hematite nanocrystals for hyperthermia application. Materials Science & Engineering C-Materials for Biological Applications, v. 120, . (16/16512-9)

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