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Pathogenesis and neurovirulence of emerging viruses in Brazil

Abstract

Emerging viruses are agents associated with a new or a previous low-prevalent disease in a specific geographic region that significantly increased their incidence that area. Among the emerging viruses in Brazil is possible to highlight: Zika (ZIKV), Oropouche (OROV), Chikungunya (CHIKV), Mayaro (MAYV) and probably La Crosse (LACV), Iquitos virus (IQTV), Japanese Encephalitis (JEV), Saint Louis encephalitis (SLEV) and West Nile virus (WNV). These agents cause a wide spectrum of diseases in humans, from asymptomatic cases, rash febrile illness until severe clinical manifestations, such as neurological syndromes (Guillain-Barré syndrome, meningoencephalitis, flaccid paralysis among others) and congenital syndromes (abortion, fetal malformations, microcephaly, eye and hearing damage and other fetal manifestations). However, the pathogenetic factors associated with the development of these so different clinical outcomes are not completely understood, but it is known that viral replication, the type of infected cells and the immune response triggered early during infection are essential phenomena to the clinical results of a viral infectious process. Thus, the aim of this project is to characterize how cells and key components of the innate immune response, including pattern recognition receptors (TLR RIG, NLR, CGAS, Sting) and molecules induced by them (such as MyD88, IR-5) control the pathogenesis and neurovirulence ZIKV and OROV. For this, we will measure viral replication, immune cell activation and production of inflammatory mediators in patients, human and mice cells isolated in vitro (neutrophils, macrophages and myeloid and plasmacytoid dendritic cells) and wild-type and selected-knockouts (KO) mice infected with ZIKV and OROV. In order to obtain samples from naturally infected humans, this project will support an arbovirus surveillance network conducted by Unicamp since February 2016. This network has monitored patients treated in Campinas, including those with rash febrile illness (children, adults and pregnant women) and neurological manifestations possibly associated viral infection. The approval of this project will set up a referenced laboratory with biosafety-security level 2 (BSL-2) for arbovirus manipulation and detection at Biology Institute of Unicamp. This Lab will support the Universitary Hospital of Campinas and will allow the development of multidisciplinary researches with professors from Medical Science School of Unicamp. In addition, the present study has collaboration with researchers from Washington University in USA and A-Star Institute in Singapore. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
El virus evoluciona 
The evolution of a virus 
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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, LUCIANA C.; BENITES, BRUNO DELTREGGIA; ULAF, RAISA G.; NUNES, THYAGO A.; COSTA-LIMA, CAROLINA; ADDAS-CARVALHO, MARCELO; PROENCA-MODENA, JOSE LUIZ; GRANJA, FABIANA; DA COSTA, VITOR ANTONIO; SANTOS DUARTE, ADRIANA DA SILVA; ZANGIROLAMI, AUDREY BASSO; AMARO, EMERSON CLAYTON; MANSOUR, ELI; ZOLLNER, RICARDO L.; VELLOSO, LICIO A. Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, v. 17, n. 1 DEC 5 2021. Web of Science Citations: 0.
DE SOUZA, WILLIAM M.; MURARO, STEFANIE P.; SOUZA, GABRIELA F.; AMORIM, MARIENE R.; SESTI-COSTA, RENATA; MOFATTO, LUCIANA S.; FORATO, JULIA; BARBOSA, PRISCILLA P.; TOLEDO-TEIXEIRA, DANIEL A.; BISPO-DOS-SANTOS, KARINA; PARISE, PIERINA L.; BRUNETTI, NATALIA S.; MOREIRA, JOSELIA C. O.; COSTA, VITOR A.; CARDOZO, DANIELA M.; MORETTI, MARIA L.; BARROS-MAZON, SILVIA; MARCHESI, GABRIELA F.; AMBROSIO, CHRISTIANE; SPILKI, FERNANDO R.; ALMEIDA, VALERIA C.; VIEIRA, ANDRE S.; ZAMBON, LAIR; FARIAS, ALESSANDRO S.; ADDAS-CARVALHO, MARCELO; BENITES, BRUNO D.; MARQUES, RAFAEL E.; SABINO, ESTER C.; VON ZUBEN, ANDREA B.; WEAVER, SCOTT C.; FARIA, NUNO R.; GRANJA, FABIANA; ANGERAMI, RODRIGO N.; PROENCA-MODENA, JOSE LUIZ. lusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccine. Viruses-Basel, v. 13, n. 11 NOV 2021. Web of Science Citations: 1.
SILVA-FILHO, JOAO LUIZ; DE OLIVEIRA, LILIAN G.; MONTEIRO, LETICIA; PARISE, PIERINA L.; ZANLUQUI, NAGELA G.; POLONIO, CAROLINA M.; DE FREITAS, CARLA L.; TOLEDO-TEIXEIRA, DANIEL A.; DE SOUZA, WILLIAM M.; BITTENCOURT, NAJARA; AMORIM, MARIENE R.; FORATO, JULIA; MURARO, STEFANIE P.; DE SOUZA, GABRIELA F.; MARTINI, MATHEUS C.; BISPO-DOS-SANTOS, KARINA; VIEIRA, ALINE; JUDICE, CARLA C.; PASTORE, GLAUCIA M.; AMARAL, ELIANA; PASSINI JUNIOR, RENATO; MAYER-MILANEZ, HELAINE M. B. P.; RIBEIRO-DO-VALLE, CAROLINA C.; CALIL, ROSELI; BENNINI JUNIOR, JOAO RENATO; LAJOS, GIULIANE J.; ALTEMANI, ALBINA; NOLASCO DA SILVA, MARCOS T.; COAN, ANA CAROLINA; COLELLA-SANTOS, MARIA FRANCISCA; VON ZUBEN, ANDREA P. B.; VINOLO, MARCO AURELIO R.; ARNS, CLARICE WEIS; CATHARINO, RODRIGO RAMOS; COSTA, MARIA LAURA; ANGERAMI, RODRIGO N.; FREITAS, ANDRE R. R.; RESENDE, MARIANGELA R.; GARCIA, MARCIA T.; MORETTI, MARIA LUIZA; RENIA, LAURENT; NG, LISA F. P.; ROTHLIN, V, CARLA; COSTA, FABIO T. M.; SCHATZMANN PERON, JEAN PIERRE; PROENCA-MODENA, JOSE LUIZ. Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. BRAIN BEHAVIOR AND IMMUNITY, v. 97, p. 260-274, OCT 2021. Web of Science Citations: 1.
LIMA, CAROLINE SPRENGEL; MOTTIN, MELINA; DE ASSIS, LETICIA RIBEIRO; DE MORAES ROSO MESQUITA, NATHALYA CRISTINA; DE PAULA SOUSA, BRUNA KATIELE; COIMBRA, LAIS DURCO; BISPO-DOS-SANTOS, KARINA; ZORN, KIMBERLEY M.; GUIDO, RAFAEL V. C.; EKINS, SEAN; MARQUES, RAFAEL ELIAS; PROENCA-MODENA, JOSE LUIZ; OLIVA, GLAUCIUS; ANDRADE, CAROLINA HORTA; REGASINI, LUIS OCTAVIO. Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors. BIOORGANIC CHEMISTRY, v. 109, APR 2021. Web of Science Citations: 1.
NOBREGA, GUILHERME M.; SAMOGIM, ANA PAULA; PARISE, PIERINA L.; VENCESLAU, EMANUELLA M.; GUIDA, JOSE PAULO S.; JAPECANGA, RODOLFO R.; AMORIM, MARIENE R.; TOLEDO-TEIXEIRA, DANIEL A.; FORATO, JULIA; CONSONNI, SILVIO R.; COSTA, MARIA LAURA; PROENCA-MODENA, JOSE LUIZ; NETWORK, ZIKA-UNICAMP. TAM and TIM receptors mRNA expression in Zika virus infected placentas. Placenta, v. 101, p. 204-207, NOV 2020. Web of Science Citations: 0.
CANDIDO, DARLAN S.; CLARO, INGRA M.; DE JESUS, JAQUELINE G.; SOUZA, WILLIAM M.; MOREIRA, FILIPE R. R.; DELLICOUR, SIMON; MELLAN, THOMAS A.; DU PLESSIS, LOUIS; PEREIRA, RAFAEL H. M.; SALES, FLAVIA C. S.; MANULI, ERIKA R.; THEZE, JULIEN; ALMEIDA, LUIZ; MENEZES, MARIANE T.; VOLOCH, CAROLINA M.; FUMAGALLI, MARCILIO J.; COLETTI, THAIS M.; SILVA, CAMILA A. M.; RAMUNDO, MARIANA S.; AMORIM, MARIENE R.; HOELTGEBAUM, HENRIQUE H.; MISHRA, SWAPNIL; GILL, MANDEV S.; CARVALHO, LUIZ M.; BUSS, LEWIS F.; PRETE JR, CARLOS A.; ASHWORTH, JORDAN; NAKAYA, I, HELDER; PEIXOTO, PEDRO S.; BRADY, OLIVER J.; NICHOLLS, SAMUEL M.; TANURI, AMILCAR; ROSSI, ATILA D.; BRAGA, V, CARLOS K.; GERBER, ALEXANDRA L.; GUIMARAES, ANA PAULA DE C.; GABURO JR, NELSON; ALENCAR, CECILA SALETE; FERREIRA, ALESSANDRO C. S.; LIMA, CRISTIANO X.; LEVI, JOSE EDUARDO; GRANATO, CELSO; FERREIRA, GIULIA M.; FRANCISCO JR, RONALDO S.; GRANJA, FABIANA; GARCIA, MARCIA T.; MORETTI, MARIA LUIZA; PERROUD JR, MAURICIO W.; CASTINEIRAS, TEREZINHA M. P. P.; LAZARI, CAROLINA S.; HILL, SARAH C.; DE SOUZA SANTOS, ANDREZA ARUSKA; SIMEONI, CAMILA L.; FORATO, JULIA; SPOSITO, ANDREI C.; SCHREIBER, ANGELICA Z.; SANTOS, MAGNUN N. N.; DE SA, CAMILA ZOLINI; SOUZA, RENAN P.; RESENDE-MOREIRA, LUCIANA C.; TEIXEIRA, MAURO M.; HUBNER, JOSY; LEME, PATRICIA A. F.; MOREIRA, RENNAN G.; NOGUEIRA, MAURICIO L.; FERGUSON, NEIL M.; COSTA, SILVIA F.; PROENCA-MODENA, JOSE LUIZ; VASCONCELOS, ANA TEREZA R.; BHATT, SAMIR; LEMEY, PHILIPPE; WU, CHIEH-HSI; RAMBAUT, ANDREW; LOMAN, NICK J.; AGUIAR, RENATO S.; PYBUS, OLIVER G.; SABINO, ESTER C.; FARIA, NUNO RODRIGUES; DISCOVERY, BRAZIL-UK CTR ARBOVIRUS. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, v. 369, n. 6508, SI, p. 1255+, SEP 4 2020. Web of Science Citations: 124.
VENCESLAU, EMANUELLA MENESES; GUIDA, JOSE PAULO; AMARAL, ELIANA; PROENCA MODENA, JOSE LUIS; COSTA, MARIA LAURA. Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature. Revista Brasileira de Ginecologia e Obstetrícia, v. 42, n. 9, p. 577-585, SEP 2020. Web of Science Citations: 0.
AMORIM, MARIENE RIBEIRO; PONTELLI, MARJORIE CORNEJO; DE SOUZA, GABRIELA FABIANO; MURARO, STEFANIE PRIMON; TOLEDO-TEIXEIRA, DANIEL A.; FORATO, JULIA; BISPO-DOS-SANTOS, KARINA; BARBOSA, NATALIA S.; MARTINI, MATHEUS CAVALHEIRO; PARISE, PIERINA LORENCINI; VIEIRA, ALINE; MILANEZ, GUILHERME PAIER; PINTO DASILVA, LUIS LAMBERTI; LALWANI, PRITESH JAYCHAND; FARIAS, ALESSANDRO SANTOS; RAMIREZ VINOLO, MARCO AURELIO; SESTI-COSTA, RENATA; ARRUDA, EURICO; PROENCA-MODENA, JOSE LUIZ. Oropouche Virus Infects, Persists and Induces IFN Response in Human Peripheral Blood Mononuclear Cells as Identified by RNA PrimeFlow (TM) and qRT-PCR Assays. Viruses-Basel, v. 12, n. 7 JUL 2020. Web of Science Citations: 0.
VENCESLAU, EMANUELLA MENESES; SIQUEIRA GUIDA, JOSE PAULO; NOBREGA, GUILHERME DE MORAES; SAMOGIM, ANA PAULA; PARISE, PIERINA LORENCINI; JAPECANGA, RODOLFO ROSA; DE TOLEDO-TEIXEIRA, DANIEL AUGUSTO; FORATO, JULIA; ANTOLINI-TAVARES, ARTHUR; SOUZA, ARETHUSA; ALTEMANI, ALBINA; CONSONNI, SILVIO ROBERTO; PASSINI, RENATO; AMARAL, ELIANA; PROENCA-MODENA, JOSE LUIZ; COSTA, MARIA LAURA; NETWORK, ZIKA-UNICAMP. Adequate Placental Sampling for the Diagnosis and Characterization of Placental Infection by Zika Virus. FRONTIERS IN MICROBIOLOGY, v. 11, FEB 21 2020. Web of Science Citations: 0.
KAM, YIU-WING; LEITE, JULIANA ALMEIDA; AMRUN, SITI NAQIAH; LUM, FOK-MOON; YEE, WEARN-XIN; ABU BAKAR, FARHANA; ENG, KAI ER; LYE, DAVID C.; LEO, YEE-SIN; CHONG, CHIA-YIN; RIBAS FREITAS, ANDRE RICARDO; MILANEZ, GUILHERME PAIER; PROENCA-MODENA, JOSE LUIZ; RENIA, LAURENT; COSTA, FABIO T. M.; NG, LISA F. P.; NETWORK, ZIKA-UNICAMP. ZIKV-Specific NS1 Epitopes as Serological Markers of Acute Zika Virus Infection. Journal of Infectious Diseases, v. 220, n. 2, p. 203-212, JUL 15 2019. Web of Science Citations: 1.
PROENCA-MODENA, JOSE LUIZ; CARDOSO, RICARDO DE SOUZA; CRIADO, MIRIA FERREIRA; MILANEZ, GUILHERME PAIER; DE SOUZA, WILLIAM MARCIEL; PARISE, PIERINA LORENCINI; BERTOL, JESSICA WILDGRUBE; SANTOS DE JESUS, BRUNA LAIS; MOREIRA PRATES, MIRELA CRISTINA; SILVA, MARIA LUCIA; BUZATTO, GUILHERME PIETRUCCI; DEMARCO, RICARDO CASSIANO; PEREIRA VALERA, FABIANA CARDOSO; TAMASHIRO, EDWIN; ANSELMO-LIMA, WILMA TEREZINHA; ARRUDA, EURICO. Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children. Journal of Medical Virology, v. 91, n. 7, p. 1250-1262, JUL 2019. Web of Science Citations: 2.
PROENCA-MODENA, JOSE LUIZ; MILANEZ, GUILHERME PAIER; COSTA, MARIA LAURA; JUDICE, CARLA C.; MARANHAO COSTA, FABIO TRINDADE. Zika virus: lessons learned in Brazil. Microbes and Infection, v. 20, n. 11-12, p. 661-669, DEC 2018. Web of Science Citations: 5.
MOTTIN, MELINA; BORBA, JOYCE V. V. B.; BRAGA, RODOLPHO C.; TORRES, PEDRO H. M.; MARTINI, MATHEUS C.; PROENCA-MODENA, JOSE LUIZ; JUDICE, CARLA C.; COSTA, FABIO T. M.; EKINS, SEAN; PERRYMAN, ALEXANDER L.; ANDRADE, CAROLINA HORTA. The A-Z of Zika drug discovery. DRUG DISCOVERY TODAY, v. 23, n. 11, p. 1833-1847, NOV 2018. Web of Science Citations: 10.
JUDICE, CARLA CRISTINA; TAN, JESLIN J. L.; PARISE, PIERINA LORENCINI; KAM, YIU-WING; MILANEZ, GUILHERME PAIER; LEITE, JULIANA ALMEIDA; CASERTA, LEONARDO CARDIA; ARNS, CLARICE WEIS; RESENDE, MARIANGELA RIBEIRO; ANGERAMI, RODRIGO; AMARAL, ELIANA; PASSINI JUNIOR, RENATO; RIBAS FREITAS, ANDRE RICARDO; MARANHAO COSTA, FABIO TRINDADE; PROENCA-MODENA, JOSE LUIZ; NG, LISA F. P.; NETWORK, ZIKA-UNICAMP. Efficient detection of Zika virus RNA in patients' blood from the 2016 outbreak in Campinas, Brazil. SCIENTIFIC REPORTS, v. 8, MAR 5 2018. Web of Science Citations: 6.
KAM, YIU-WING; LEITE, JULIANA ALMEIDA; LUM, FOK-MOON; TAN, JESLIN J. L.; LEE, BERNETT; JUDICE, CARLA C.; DE TOLEDO TEIXEIRA, DANIEL AUGUSTO; ANDREATA-SANTOS, ROBERT; VINOLO, MARCO A.; ANGERAMI, RODRIGO; RESENDE, MARIANGELA RIBEIRO; RIBAS FREITAS, ANDRE RICARDO; AMARAL, ELIANA; PASSINI JUNIOR, RENATO; COSTA, MARIA LAURA; GUIDA, JOSE PAULO; ARNS, CLARICE WEIS; FERREIRA, LUIS CARLOS S.; NIA, LAURENT R.; PROENCA-MODENA, JOSE LUIZ; NG, LISA F. P.; COSTA, FABIO T. M.; NETWORK, ZIKA-UNICAMP. Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil. Journal of Infectious Diseases, v. 216, n. 2, p. 172-181, JUL 15 2017. Web of Science Citations: 26.

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