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Pathophysiological changes during systemic inflammation

Grant number: 16/17681-9
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2017 - August 31, 2022
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Luiz Guilherme de Siqueira Branco
Grantee:Luiz Guilherme de Siqueira Branco
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Evelin Capellari Cárnio
Associated scholarship(s):22/01783-8 - Effects of fluoxetine pretreatment on endotoxemia-induced hypothermia, BP.MS
21/05371-3 - Anti-inflammatory action of angiotensin-(1-7) on cardiovascular complications induced by experimental Sepsis, BP.DD
21/10152-9 - Pathophysiological changes during systemic inflammation, BP.TT
+ associated scholarships 20/15022-3 - Characterization of Clostridium beijerinkii Br21 as a probiotic and psychobiotic, BP.PD
21/03084-7 - Pathophysiological changes during systemic inflammation, BP.TT
20/12777-3 - "Interaction between Angiotensin-converting enzyme 2 and serotonin during systemic inflammation", BP.PD
20/11003-4 - Anti-inflammatory action of the renin-angiotensin system in fever and hypothermia during experimental sepsis, BP.IC
19/27231-9 - Effect of fluvoxamine on neuroimmune alterations in septic rats, BP.PD
19/00832-2 - Relation between body temperature and nitric oxide in rats undergoing septic shock, BP.IC
18/18459-3 - Physiopathological changes during systemic inflammation, BP.TT
18/14226-4 - The role of the inflammatory reflex in the endotoxin tolerance, BP.IC
17/01633-8 - Role of serotonin in the preoptic area in the modulation of body temperature and nociception during systemic inflammation, BP.DR
17/09878-0 - Effect of vagal stimulation during LPS immune challenge in normotensive and spontaneously hypertensive rats, BP.PD
17/03645-3 - Role of hydrogen sulfide in orofacial allodynia modulation in an experimental model of arterial hypertension, BP.IC
17/04644-0 - The role of central serotonin modulating mechanical and thermal nociception during systemic inflammation, BP.IC
17/04610-9 - Citral on euthymia and fever, BP.IC - associated scholarships

Abstract

The systemic inflammatory response syndrome (SIRS) is an inflammatory condition that affects the whole body and represents a serious threat. Endotoxemia, sepsis and its complications (septic shock and multiple organ failure) are the major cause of death in intensive care units worldwide, despite recent major technological advances. Lack of knowledge of the pathophysiological mechanisms of this condition and the aging population are facts related to this situation. In recent years, we settled in our laboratories an experimental model to unravel the mechanisms involved in immune responses to the endotoxin challenge more specifically we assessed the participation of gaseous neuromodulators (nitric oxide, carbon monoxide and hydrogen sulfide) in the central nervous system. We have published articles in peer reviewed journals and chapters in books; facts that reinforce recognition of the world front scientific community to our work. This proposal aims to improve the efficiency of our work, enabling the increase in the number of students and researchers involved, expanding knowledge about the nervous, hormonal, cardiovascular, thermoregulatory and behavioral changes that take place during and after experimental systemic inflammation induced by endotoxin. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (35)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, BRUNA M.; FRANCESCATO, HELOISA D. C.; TURCATO, FLAVIA C.; ANTUNES-RODRIGUES, JOSE; COIMBRA, TEREZILA M.; BRANCO, LUIZ G. S.. Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE(2) production. ACTA PHYSIOLOGICA, . (16/09364-3, 16/17681-9)
DE DEUS, JUNIA L.; AMORIM, MATEUS R.; RIBEIRO, ALINE B.; BARCELLOS-FILHO, PROCOPIO C. G.; CEBALLOS, CESAR C.; BRANCO, LUIZ GUILHERME S.; CUNHA, ALEXANDRA O. S.; LEAO, RICARDO M.. Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound. Cellular and Molecular Neurobiology, v. 41, n. 4, . (16/17681-9, 15/22327-7, 16/01607-4)
SORIANO, RENATO N.; BRAGA, SARA P.; BREDER, JESSICA S. C.; BATALHAO, MARCELO E.; OLIVEIRA-PELEGRIN, GABRIELA R.; FERREIRA, LUIZ FERNANDO R.; ROCHA, MARIA JOSE A.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Endogenous peripheral hydrogen sulfide is propyretic: its permissive role in brown adipose tissue thermogenesis in rats. Experimental Physiology, v. 103, n. 3, p. 397-407, . (16/17681-9, 12/01417-0, 15/24950-3)
AMORIM, MATEUS R.; MOREIRA, DIEGO A.; SANTOS, BRUNA M.; FERRARI, GUSTAVO D.; NOGUEIRA, JONATAS E.; DE DEUS, JUNIA L.; ALBERICI, LUCIANE C.; BRANCO, LUIZ G. S.. Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE(2)production and increased heat loss. JOURNAL OF PHYSIOLOGY-LONDON, . (17/09878-0, 16/17681-9)
COSTA, LUIS H. A.; SANTOS, BRUNA M.; BRANCO, LUIZ G. S.. Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?. European Journal of Pharmacology, v. 889, . (19/27231-9, 16/17681-9)
MOTA, CLARISSA M. D.; BORGES, GABRIELA S.; AMORIM, MATEUS R.; CAROLINO, RUITHER O. G.; BATALHAO, MARCELO E.; ANSELMO-FRANCI, JANETE A.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation. BRAIN BEHAVIOR AND IMMUNITY, v. 80, p. 255-265, . (17/09878-0, 16/17681-9)
AMORIM, MATEUS R.; DE DEUS, JUNIA L.; CAZUZA, RAFAEL A.; MOTA, CLARISSA M. D.; DA SILVA, LUIZ E. V.; BORGES, GABRIELA S.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation. JOURNAL OF NEUROINFLAMMATION, v. 16, . (17/09878-0, 17/01633-8, 16/17681-9)
JACOB SABINO, JOAO PAULO; DE CASTRO OLIVEIRA, LUCAS VAZ; SORIANO, RENATO NERY; KWIATKOSKI, MARCELO; BRANCO, LUIZ G. S.; DA SILVA, GLAUBER S. F.. Role of hydrogen sulfide in ventilatory responses to hypercapnia in the medullary raphe of adult rats. Experimental Physiology, v. 106, n. 9, p. 1992-2001, . (15/24950-3, 11/14779-4, 16/17681-9)
NOGUEIRA, JONATAS E.; AGOSTINHO, BRENDA K. L.; MOTA, CLARISSA M. D.; BRANCO, LUIZ G. S.. Splenic anti-inflammatory reflex in immune tolerance. Journal of Thermal Biology, v. 85, . (17/01633-8, 16/17681-9)
DE DEUS, JUNIA LARA; AMORIM, MATEUS RAMOS; DA SILVA JUNIOR, RUI MILTON PATRICIO; JESUS, ALINE ALVES; DE BARCELLOS FILHO, PROCOPIO CLEBER GAMA; CARNIO, EVELIN CAPELLARI; CUNHA, ALEXANDRA OLIMPIO SIQUEIRA; LEAO, RICARDO MAURICIO; BRANCO, LUIZ G. S.. Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation. BRAIN, BEHAVIOR, & IMMUNITY - HEALTH, v. 31, p. 10-pg., . (16/17681-9, 17/09878-0, 16/01607-4)
FAIM, FELIPE; PASSAGLIA, PATRICIA; BATALHAO, MARCELO; LACCHINI, RICCARDO; STABILE, ANGELITA MARIA; CARNIO, EVELIN CAPELLARI. Role of ghrelin on growth hormone/insulin-like growth factor-1 axis during endotoxemia. GROWTH HORMONE & IGF RESEARCH, v. 48-49, p. 36-44, . (15/09857-7, 16/17681-9)
DE DEUS, JUNIA LARA; AMORIM, MATEUS RAMOS; GAMA DE BARCELLOS FILHO, PROCOPIO CLEBER; CORTES DE OLIVEIRA, JOSE ANTONIO; BATALHAO, MARCELO EDUARDO; GARCIA-CAIRASCO, NORBERTO; CARNIO, EVELIN CAPELLARI; LEAO, RICARDO MAURICIO; DE SIQUEIRA BRANCO, LUIZ GUILHERME; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO. Inflammatory markers in the hippocampus after audiogenic kindling. Neuroscience Letters, v. 721, . (17/09878-0, 15/22327-7, 16/01607-4, 16/17681-9)
NOGUEIRA, JONATAS E.; BRANCO, LUIZ G. S.. Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation. CURRENT PHARMACEUTICAL DESIGN, v. 27, n. 5, p. 731-736, . (16/17681-9)
DA SILVA JUNIOR, CARLOS APARECIDO; MARQUES, DANUZIA A.; PATRONE, LUIS GUSTAVO A.; BIANCARDI, VIVIAN; BICEGO, KENIA C.; GARGAGLIONI, LUCIANE H.. Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats. Neuroscience Letters, v. 795, p. 8-pg., . (20/01702-2, 16/17681-9, 17/26367-9, 17/05318-0)
DIAS MOTA, CLARISSA MARIA; ALVES DA ROCHA, MARIA JOSE; ANTUNES-RODRIGUES, JOSE; DE SIQUEIRA BRANCO, LUIZ GUILHERME. Central Fractalkine Induces Systemic Inflammation Independently of Hypothalamic Prostaglandin E2. FASEB JOURNAL, v. 32, n. 1, p. 2-pg., . (17/01633-8, 16/17681-9)
SANTOS, BRUNA M.; COSTA, LUIS H. A.; ROCHA, MARIA J.; BRANCO, LUIZ G. S.. Central leukotrienes modulate fever tolerance to LPS in rats. Journal of Thermal Biology, v. 84, p. 245-249, . (16/09364-3, 16/17681-9)
PASSAGLIA, PATRICIA; SILVA, HADDER BATISTA; DE JESUS, ALINE ALVES; MARANGA FILHO, MARCO ANTONIO; TRAJANO, ISIS PAIVA; BATALHA, MARCELO EDUARDO; NAVEGANTES, LUIZ CARLOS CARVALHO; BRANCO, LUIZ GUILHERME SIQUEIRA; CARNIO, EVELIN CAPELLARI. Angiotensin-(1-7) improves tail skin heat loss and increases the survival of rats with polymicrobial sepsis. Peptides, v. 167, p. 9-pg., . (16/17681-9, 20/11003-4)
EMILIO-SILVA, MAYCON T.; MOTA, CLARISSA M. D.; HIRUMA-LIMA, CLELIA A.; ANTUNES-RODRIGUES, JOSE; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Antipyretic Effects of Citral and Possible Mechanisms of Action. Inflammation, v. 40, n. 5, p. 1735-1741, . (16/17681-9)
MOTA, CLARISSA M. D.; ANTUNES-RODRIGUES, JOSE; BRANCO, LUIZ G. S.. Central fractalkine stimulates central prostaglandin E-2 production and induces systemic inflammatory responses. Brain Research Bulletin, v. 140, p. 311-317, . (17/01633-8, 16/17681-9)
SARAMAGO, EDUARDO A.; BORGES, GABRIELA S.; SINGOLANI-, JR., CARLITOS G.; NOGUEIRA, JONATAS E.; SORIANO, RENATO N.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Molecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced systemic inflammation. BRAIN BEHAVIOR AND IMMUNITY, v. 75, p. 119-128, . (16/17681-9)
NOGUEIRA, JONATAS E.; PASSAGLIA, PATRICIA; MOTA, CLARISSA M. D.; SANTOS, BRUNA M.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status. Free Radical Biology and Medicine, v. 129, p. 186-193, . (16/17681-9)
SANTOS, BRUNA M.; SANTOS, WANDERSON S.; SOLON, ISABELLY G.; GARCIA, FELIPE S.; EMILIO-SILVA, MAYCON T.; JESUS, ALINE A.; HIRUMA-LIMA, CLELIA A.; NASCIMENTO, GLAUCE C.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats. ARCHIVES OF ORAL BIOLOGY, v. 152, p. 7-pg., . (16/09364-3, 16/17681-9)
SANTOS, BRUNA M.; FRANCESCATO, HELOISA D. C.; TURCATO, FLAVIA C.; ANTUNES-RODRIGUES, JOSE; COIMBRA, TEREZILA M.; BRANCO, LUIZ G. S.. Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE(2) production. ACTA PHYSIOLOGICA, v. 228, n. 3, p. 12-pg., . (16/09364-3, 16/17681-9)
AMORIM, MATEUS R.; DE DEUS, JUNIA L.; PEREIRA, CAMILA A.; DA SILVA, LUIZ E. V.; BORGES, GABRIELA S.; FERREIRA, NATHANNE S.; BATALHAO, MARCELO E.; ANTUNES-RODRIGUES, JOSE; CARNIO, EVELIN C.; TOSTES, RITA C.; et al. Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation. SCIENTIFIC REPORTS, v. 10, n. 1, . (17/09878-0, 16/17681-9)
NOGUEIRA, JONATAS E.; DE DEUS, JUNIA L.; AMORIM, MATEUS R.; BATALHAO, MARCELO E.; LEAO, RICARDO M.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Inhaled molecular hydrogen attenuates intense acute exercise-induced hippocampal inflammation in sedentary rats. Neuroscience Letters, v. 715, . (16/17681-9)
MOTA, CLARISSA M. D.; RODRIGUES-SANTOS, CAROLINE; CAROLINO, RUITHER O. G.; ANSELMO-FRANCI, JANETE A.; BRANCO, LUIZ G. S.. Citral-induced analgesia is associated with increased spinal serotonin, reduced spinal nociceptive signaling, and reduced systemic oxidative stress in arthritis. Journal of Ethnopharmacology, v. 250, . (17/04644-0, 16/17681-9)
SANTOS, BRUNA M.; NASCIMENTO, GLANCE C.; CAPEL, CAMILA P.; BORGES, GABRIELA S.; ROSOLEN, THALES; SABINO, JOAO P. J.; LEITE-PANISSI, CHRISTIE R. A.; BRANCO, LUIZ G. S.. Sex differences and the role of ovarian hormones in site-specific nociception of SHR. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 317, n. 2, p. R223-R231, . (17/03645-3, 16/09364-3, 16/17681-9)
DE MELLO ROSA, GUSTAVO HENRIQUE; ULLAH, FARHAD; DE PAIVA, YARA BEZERRA; DA SILVA, JULIANA ALMEIDA; BRANCO, LUIZ GUILHERME S.; CORRADO, ALEXANDRE PINTO; MEDEIROS, PRISCILA; COIMBRA, NORBERTO CYSNE; BIAGIONI, AUDREY FRANCESCHI. Ventrolateral periaqueductal gray matter integrative system of defense and antinociception. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 474, n. 4, p. 12-pg., . (15/10313-1, 17/13560-5, 16/18218-0, 16/17681-9, 09/54014-7, 14/10742-7)
JACOB SABINO, JOAO PAULO; DE CASTRO OLIVEIRA, LUCAS VAZ; SORIANO, RENATO NERY; KWIATKOSKI, MARCELO; BRANCO, LUIZ G. S.; DA SILVA, GLAUBER S. F.. Role of hydrogen sulfide in ventilatory responses to hypercapnia in the medullary raphe of adult rats. Experimental Physiology, . (11/14779-4, 15/24950-3, 16/17681-9)
DA SILVA JUNIOR, CARLOS APARECIDO; PATRONE, LUIS GUSTAVO A.; BIANCARDI, VIVIAN; VILELA-COSTA, HELOISA H.; MARQUES, DANUZIA A.; CRISTINA-SILVA, CAROLINE; DA COSTA SILVA, KAOMA STEPHANI; BICEGO, KENIA C.; SZAWKA, RAPHAEL E.; GARGAGLIONI, LUCIANE H.. Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 474, n. 11, p. 16-pg., . (17/05318-0, 16/17681-9, 20/01702-2, 17/26367-9)
FONSECA, ELISA M.; NORONHA-DE-SOUZA, CAROLINA R.; BICEGO, KENIA C.; BRANCO, LUIZ G. S.; GARGAGLIONI, LUCIANE H.. 5-HT neurons of the medullary raphe contribute to respiratory control in toads. Respiratory Physiology & Neurobiology, v. 293, . (19/09469-8, 16/17681-9)
NOGUEIRA, JONATAS E.; AMORIM, MATEUS R.; PINTO, ANA P.; DA ROCHA, ALISSON L.; DA SILVA, ADELINO S. R.; BRANCO, LUIZ G. S.. Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage. Canadian Journal of Physiology and Pharmacology, v. 99, n. 8, p. 812-820, . (17/09878-0, 16/17681-9, 17/19869-8, 17/12765-2)
AMORIM, MATEUS R.; MOREIRA, DIEGO A.; SANTOS, BRUNA M.; FERRARI, GUSTAVO D.; NOGUEIRA, JONATAS E.; DE DEUS, JUNIA L.; ALBERICI, LUCIANE C.; BRANCO, LUIZ G. S.. Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE(2)production and increased heat loss. JOURNAL OF PHYSIOLOGY-LONDON, v. 598, n. 20, p. 18-pg., . (17/09878-0, 16/17681-9)
AMORIM, MATEUS R.; DE JESUS, ALINE A.; SANTOS-JUNIOR, NILTON N.; ROCHA, MARIA J. A.; NOGUEIRA, JONATAS E.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Autonomic Disbalance During Systemic Inflammation is Associated with Oxidative Stress Changes in Sepsis Survivor Rats. Inflammation, . (17/09878-0, 16/17681-9)
GARATTINI, EMANUELA G.; SANTOS, BRUNA M.; FERRARI, DANIELE P.; CAPEL, CAMILA P.; FRANCESCATO, HELOISA D. C.; COIMBRA, TEREZILA M.; LEITE-PANISSI, CHRISTIE R. A.; BRANCO, LUIZ G. S.; NASCIMENTO, GLAUCE C.. Propargylglycine decreases neuro-immune interaction inducing pain response in temporomandibular joint inflammation model. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 93, p. 90-101, . (15/03053-3, 17/03645-3, 16/09364-3, 16/17681-9)

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