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Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity

Grant number: 15/23376-1
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2017 - November 30, 2022
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Thiago dos Santos Moreira
Grantee:Thiago dos Santos Moreira
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Ana Carolina Thomaz Takakura
Associated researchers:Norberto Garcia Cairasco
Associated grant(s):17/12072-7 - Multi-user equipment approved in grant 2015/23376-1: Zeiss AxioImager microscope with fluorescence, light/dark field, digital camera and hardware and system analysis, AP.EMU
Associated scholarship(s):21/09377-6 - Contribution of the sensorial olfactory neurons in the hypercapnia and hypoxia ventilatory response in conscious mice, BP.DD
21/02006-2 - Involvement of microglial cells in the retrotrapezoid nucleus in response to the activation of the chemoreflex, BP.IC
19/20504-0 - Respiratory changes elicit by neurokinin receptors at the level of the retrotrapezoid nucleus, BP.DR
+ associated scholarships 20/08620-1 - Hypothalamus and retrotrapezoid nucleus interaction in the control of breathing activity, BP.DR
19/20990-1 - Contribution of the sensorial olfactory neurons in the hypercapnia ventilatory response in conscious mice, BP.MS
19/09718-8 - Role of microglial cell activation in response to increased levels of CO2 in the control of respiratory activity, BP.IC
19/09323-3 - Regulation of blood flow in the ventrolateral surface of the medulla in animal a model of Parkinson's disease, BP.PD
18/13707-9 - Involvement of the chemosensitive neurons in the retrotrapezoid nucleus for the control of postinspiratory activity, BP.DR
18/13704-0 - Study of the influence of omega-3 in the respiratory changes observed in a model of Parkinson's Disease induced by bilateral injection of 6-hydroxy-dopamine in CPU, BP.IC
17/08696-5 - Purinergic signalling within the Retrotrapezoid Nucleus region: role of breathing control in the temporal lobe epilepsy model, BP.PD
17/10242-2 - Role of OLIG3 transcription factor on ventilatory responses to hypoxia and hypercapnia, BP.IC
17/01380-2 - Pedunculo pontine tegmental nucleus and brainstem respiratory interactions in breathing, BP.DD - associated scholarships

Abstract

Breathing automaticity and chemoreception are inseparable neural processes. The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO2 constant. Additional evidence that RTN neurons have central respiratory chemoreceptor properties is presented, but this is only one of many factors that determine their activity. The RTN is also regulated by powerful inputs from the carotid bodies and, at least in the adult, by many other synaptic inputs. It is also established that RTN neurons may control the activity of the downstream central respiratory pattern generator. Specifically, RTN neurons (a) innervate the entire ventral respiratory column and (b) control both inspiration and expiration. Based on the information above, this project will intend to analyze the role of RTN chemoreceptors neurons in the control of breathing under physiological, pathological and during development in mammals. (AU)

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Scientific publications (53)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, LUIZ M.; TUPPY, MARINA; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Role of the locus coeruleus catecholaminergic neurons in the chemosensory control of breathing in a Parkinson's disease model. Experimental Neurology, v. 293, p. 172-180, . (15/18842-3, 16/23281-3, 14/22406-1, 15/23376-1)
SHI, YINGTANG; SOBRINHO, CLEYTON R.; SOTO-PEREZ, JASEPH; MILLA, BRENDA M.; STORNETTA, DANIEL S.; STORNETTA, RUTH L.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.; BAYLISS, DOUGLAS A.. 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity. JOURNAL OF PHYSIOLOGY-LONDON, v. 600, n. 11, p. 23-pg., . (15/23376-1, 19/01236-4)
SILVA, TALITA M.; BORNIGER, JEREMY C.; ALVES, MICHELE JOANA; CORREA, DIEGO ALZATE; ZHAO, JING; FADDA, PAOLO; TOLAND, AMANDA EWART; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; CZEISLER, CATHERINE M.; et al. Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in Phox2b-derived astrocytes ablated mice. Journal of Neurophysiology, v. 125, n. 4, p. 1164-1179, . (15/23376-1, 18/03994-0, 19/01236-4)
BATISTA, LUARA A.; CABRAL, LAIS M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. nhibition of anandamide hydrolysis does not rescue respiratory abnormalities observed in an animal model of Parkinson's diseas. Experimental Physiology, v. 107, n. 2, . (19/01236-4, 17/18074-1, 15/23376-1)
MALHEIROS-LIMA, MILENE R.; SILVA, TALITA M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. 5 noradrenergic-projecting C1 neurons activate sympathetic and breathing outputs in anaesthetized rat. Experimental Physiology, v. 107, n. 2, . (17/08696-5, 19/01236-4, 15/23376-1)
OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Forebrain and Hindbrain Projecting-neurons Target the Post-inspiratory Complex Cholinergic Neurons. Neuroscience, v. 476, p. 102-115, . (15/23376-1, 19/09323-3, 19/01236-4)
OLIVEIRA, LUIZ M.; HENRIQUE, ELISANDRA; BUSTELLI, ISABELLA B.; NETTO, NELSON F. C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.; CAETANO, ARIADINY L.. Depletion of hypothalamic hypocretin/orexin neurons correlates with impaired memory in a Parkinson's disease animal model. Experimental Neurology, v. 323, . (17/20420-5, 16/23281-3, 17/12266-6, 15/23376-1, 15/18842-3)
FERNANDES-JUNIOR, SILVIO A.; OLIVEIRA, LUIZ M.; CZEISLER, CATHERINE M.; MO, XIAOKUI; ROY, SASHWATI; SOMOGYI, ARPAD; ZHANG, LIEWN; MOREIRA, THIAGO S.; OTERO, JOSE J.; TAKAKURA, ANA C.. Stimulation of retrotrapezoid nucleus Phox2b-expressing neurons rescues breathing dysfunction in an experimental Parkinson's disease rat model. Brain Pathology, v. 30, n. 5, . (16/23281-3, 14/20695-6, 15/23376-1, 17/11165-1)
MALHEIROS-LIMA, MILENE R.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. DEPLETION OF ROSTRAL VENTROLATERAL MEDULLARY CATECHOLAMINERGIC NEURONS IMPAIRS THE HYPDXIC VENTILATORY RESPONSE IN CONSCIOUS RATS. Neuroscience, v. 351, p. 1-14, . (14/07698-6, 14/22406-1, 15/23376-1)
HAWKINS, VIRGINIA E.; TAKAKURA, ANA C.; TRINH, ASHLEY; MALHEIROS-LIMA, MILENE R.; CLEARY, COLIN M.; WENKER, IAN C.; DUBREUIL, TODD; RODRIGUEZ, ELLIOT M.; NELSON, MARK T.; MOREIRA, THIAGO S.; et al. Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe. eLIFE, v. 6, . (14/07698-6, 14/22406-1, 15/23376-1, 16/22069-0)
ANDRADE, DAVID C.; TOLEDO, CAMILO; DIAZ, HUGO S.; LUCERO, CLAUDIA; ARCE-ALVAREZ, ALEXIS; OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; SCHULTZ, HAROLD D.; MARCUS, NOAH J.; et al. Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure. Clinical Science, v. 133, n. 3, p. 393-405, . (15/23376-1, 16/23281-3)
MALHEIROS-LIMA, MILENE R.; SILVA, JOSIANE N.; SOUZA, FELIPE C.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. C1 neurons are part of the circuitry that recruits active expiration in response to the activation of peripheral chemoreceptors. eLIFE, v. 9, . (16/23281-3, 15/23376-1)
DIAZ, HUGO S.; ANDRADE, DAVID C.; TOLEDO, CAMILO; PEREYRA, V, KATHERIN; SCHWARZ, KARLA G.; DIAZ-JARA, ESTEBAN; LUCERO, CLAUDIA; ARCE-ALVAREZ, ALEXIS; SCHULTZ, HAROLD D.; SILVA, JOSIANE N.; et al. Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v. 318, n. 1, p. L27-L40, . (16/22069-0, 15/23376-1, 16/23281-3)
TOTOLA, LEONARDO T.; MALHEIROS-LIMA, MILENE R.; DELFINO-PEREIRA, POLIANNA; DEL VECCHIO, FLAVIO; SOUZA, FELIPE C.; TAKAKURA, ANA C.; GARCIA-CAIRASCO, NORBERTO; MOREIRA, THIAGO S.. Amygdala rapid kindling impairs breathing in response to chemoreflex activation. Brain Research, v. 1718, p. 159-168, . (16/23281-3, 05/56447-7, 15/23376-1)
OLIVEIRA, LUIZ M.; OLIVEIRA, MARIA A.; MORIYA, HENRIQUE T.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Respiratory disturbances in a mouse model of Parkinson's disease. Experimental Physiology, v. 104, n. 5, p. 729-739, . (15/23376-1, 16/23281-3, 15/18842-3, 17/12266-6)
MOREIRA, THIAGO S.; ANTUNES, VAGNER R.; FALQUETTO, BARBARA; MARINA, NEPHTALI. Long-term stimulation of cardiac vagal preganglionic neurons reduces blood pressure in the spontaneously hypertensive rat. Journal of Hypertension, v. 36, n. 12, p. 2444-2452, . (15/23376-1, 16/21991-3, 16/22069-0)
FERNANDES-JUNIOR, SILVIO A.; CARVALHO, KARIN S.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Correlation between neuroanatomical and functional respiratory changes observed in an experimental model of Parkinson's disease. Experimental Physiology, v. 103, n. 10, p. 1377-1389, . (15/23376-1, 16/23281-3)
SOBRINHO, CLEYTON R.; GONCALVES, CHRISTOPHER M.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. Fluorocitrate-mediated depolarization of astrocytes in the retrotrapezoid nucleus stimulates breathing. Journal of Neurophysiology, v. 118, n. 3, p. 1690-1697, . (14/22406-1, 11/13462-7, 15/23376-1, 15/12827-2, 16/22069-0)
MALHEIROS-LIMA, MILENE R.; TOTOLA, LEONARDO T.; LANA, MARLOUS V. G.; STRAUSS, BRYAN E.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Breathing responses produced by optogenetic stimulation of adrenergic C1 neurons are dependent on the connection with preBotzinger complex in rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 470, n. 11, p. 1659-1672, . (14/07698-6, 15/23376-1, 16/23281-3, 16/22069-0)
ZOCCAL, DANIEL B.; SILVA, JOSIANE N.; BARNETT, WILLIAM H.; LEMES, EDUARDO V.; FALQUETTO, BARBARA; COLOMBARI, EDUARDO; MOLKOV, YAROSLAV I.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Interaction between the retrotrapezoid nucleus and the parafacial respiratory group to regulate active expiration and sympathetic activity in rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v. 315, n. 5, p. L891-L909, . (14/22406-1, 13/17251-6, 15/23376-1, 16/23281-3, 09/54888-7, 16/22069-0)
SILVA, TALITA M.; WASINSKI, FREDERICK; FLOR, KARINE C.; LIST, EDWARD O.; KOPCHICK, JOHN J.; TAKAKURA, ANA C.; DONATO JR, JOSE; MOREIRA, THIAGO S.. The effect of central growth hormone action on hypoxia ventilatory response in conscious mice. Brain Research, v. 1791, p. 10-pg., . (16/20897-3, 20/01318-8, 15/23376-1, 18/13707-9)
SOBRINHO, C. R.; MILLA, B. M.; SOTO-PEREZ, J.; MOREIRA, T. S.; MULKEY, D. K.. Histamine/H1 receptor signaling in the parafacial region increases activity of chemosensitive neurons and respiratory activity in rats. Journal of Neurophysiology, v. 128, n. 1, p. 11-pg., . (15/23376-1, 16/23077-7, 15/12827-2)
DE LA ROSA, TOMAS; CALVO, VIVIAM S.; GONCALVES, VALERIA C.; FERREIRA, CAROLINE B.; CABRAL, LAIS M.; SOUZA, FELIPE DA COSTA; SCERNI, DEBORA A.; SCORZA, FULVIO A.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Respiratory deficits in a female rat model of Parkinson's disease. Experimental Physiology, v. 107, n. 11, p. 11-pg., . (15/23376-1, 19/01236-4)
MORETTI, EDUARDO H.; RODRIGUES, ABNER C.; MARQUES, BRUNO V.; TOTOLA, LEONARDO T.; FERREIRA, CAROLINE B.; BRITO, CAMILA F.; MATOS, CAROLINE M.; DA SILVA, FILIPE A.; SANTOS, ROBSON A. S.; LOPES, LUCIANA B.; et al. Autoregulation of blood flow drives early hypotension in a rat model of systemic inflammation induced by bacterial lipopolysaccharide. PNAS NEXUS, v. 2, n. 2, p. 13-pg., . (18/13877-1, 20/00631-4, 18/03418-0, 20/09399-7, 15/23376-1, 18/21934-5)
OLIVEIRA, LUIZ M.; SEVERS, LIZA; MOREIRA, THIAGO S.; RAMIREZ, JAN-MARINO; TAKAKURA, ANA C.. Ampakine CX614 increases respiratory rate in a mouse model of Parkinson's disease. Brain Research, v. 1815, p. 6-pg., . (19/09323-3, 19/01236-4, 15/23376-1, 17/12266-6)
SILVA, JOSIANE DO N.; OLIVEIRA, LUIZ M.; SOUZA, FELIPE C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. GABAergic neurons of the medullary raphe regulate active expiration during hypercapnia. Journal of Neurophysiology, v. 123, n. 5, p. 1933-1943, . (15/23376-1, 16/23281-3, 14/23418-3)
MIRANDA, NICOLE C.; OLIVEIRA, LUIZ M.; AQUINO, YASMIN C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. The Pedunculopontine Tegmental Nucleus is not Important for Breathing Impairments Observed in a Parkinson?s Disease Model. Neuroscience, v. 512, p. 15-pg., . (19/01236-4, 15/23376-1, 20/16320-8)
MOREIRA, THIAGO S.; BARRETO-FILHO, JOSE A.; SEABRA-GARCEZ, JULIANE D.; GARCEZ, FLAVIA BARRETO; DRAGER, LUCIANO F.. Last Word on Viewpoint: Nondyspnogenic acute hypoxemic respiratory failure in COVID-19 pneumonia-Breathing pattern in patients with SARS-CoV-2. Journal of Applied Physiology, v. 130, n. 3, p. 900, . (15/23376-1)
LIMA, JANAYNA D.; SOBRINHO, CLEYTON R.; SANTOS, LEONARDO K.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. M4-muscarinic acetylcholine receptor into the pedunculopontine tegmental nucleus mediates respiratory modulation of conscious rats. Respiratory Physiology & Neurobiology, v. 269, . (16/23281-3, 15/23376-1, 15/12827-2, 17/01380-2)
MAIA, OCTAVIO A. C.; MALHEIROS-LIMA, MILENE R.; OLIVEIRA, MARIA A.; CASTRO, CLAUDIO L.; MORIYA, HENRIQUE T.; TAVARES-DE-LIMA, WOTHAN; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Pilocarpine-induced status epilepticus reduces chemosensory control of breathing. Brain Research Bulletin, v. 161, p. 98-105, . (15/23376-1, 16/23281-3, 17/08696-5)
CZEISLER, CATHERINE M.; SILVA, TALITA M.; FAIR, SUMMER R.; LIU, JILLIAN; TUPAL, SRINIVASAN; KAYA, BEHIYE; COWGILL, AARON; MAHAJAN, SALIL; SILVA, PHELIPE E.; WANG, YANGYANG; et al. The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 8, p. 2225-2251, . (15/23376-1, 16/23281-3, 16/22069-0)
OLIVEIRA, LUIZ M.; FALQUETTO, BARBARA; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Orexinergic neurons are involved in the chemosensory control of breathing during the dark phase in a Parkinson's disease model. Experimental Neurology, v. 309, p. 107-118, . (16/23281-3, 16/22069-0, 17/12266-6, 15/23376-1, 15/18842-3, 15/11268-0)
MALHEIROS-LIMA, MILENE R.; ANTUNES, VAGNER R.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Hypertension and sympathetic nervous system overactivity rely on the vascular tone of pial vessels of the rostral ventrolateral medulla in spontaneously hypertensive rats. Experimental Physiology, v. 105, n. 1, p. 65-74, . (15/23376-1, 16/23281-3, 16/21991-3, 16/22069-0, 17/08696-5)
TOLEDO, CAMILO; ANDRADE, DAVID C.; DIAZ, HUGO S.; PEREYRA, KATHERIN V.; SCHWARZ, KARLA G.; DIAZ-JARA, ESTEBAN; OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; SCHULTZ, HAROLD D.; et al. Rostral ventrolateral medullary catecholaminergic neurones mediate irregular breathing pattern in volume overload heart failure rats. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 24, . (15/23376-1, 16/23281-3)
ALZATE-CORREA, DIEGO; LIU, JILLIAN MEI-LING; JONES, MIKAYLA; SILVA, TALITA M.; ALVES, MICHELE JOANA; BURKE, ELIZABETH; ZUNIGA, JESSICA; KAYA, BEHIYE; ZAZA, GIULIANA; ASLAN, MEHMET TAHIR; et al. Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non-cell autonomous developmental mechanisms. Brain Pathology, v. 31, n. 1, . (15/23376-1, 16/23281-3)
JAMES, S. D.; HAWKINS, V. E.; FALQUETTO, B.; RUSKIN, D. N.; MASINO, S. A.; MOREIRA, T. S.; OLSEN, M. L.; MULKEY, D. K.. Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus. ENEURO, v. 5, n. 6, . (14/04866-5, 15/23376-1, 16/22069-0)
TAKAKURA, ANA C.; MALHEIROS-LIMA, MILENE R.; MOREIRA, THIAGO S.. Excitatory and inhibitory modulation of parafacial respiratory neurons in the control of active expiration. Respiratory Physiology & Neurobiology, v. 289, . (17/08696-5, 19/01236-4, 15/23376-1)
OLIVEIRA, LUIZ M.; BAERTSCH, NATHAN A.; MOREIRA, THIAGO S.; RAMIREZ, JAN-MARINO; TAKAKURA, ANA C.. Unraveling the Mechanisms Underlying Irregularities in Inspiratory Rhythm Generation in a Mouse Model of Parkinson's Disease. JOURNAL OF NEUROSCIENCE, v. 41, n. 21, p. 4732-4747, . (15/23376-1, 19/09323-3, 19/01236-4)
FALQUETTO, BARBARA; THIEME, KARINA; MALTA, MARILIA B.; ROCHA, KARINA C. E.; TUPPY, MARINA; POTJE, SIMONE R.; ANTONIALI, CRISTINA; RODRIGUES, ALICE C.; MUNHOZ, CAROLINA D.; MOREIRA, THIAGO S.; et al. Oxidative stress in the medullary respiratory neurons contributes to respiratory dysfunction in the 6-OHDA model of Parkinson's disease. JOURNAL OF PHYSIOLOGY-LONDON, v. 598, n. 22, . (19/01236-4, 18/05426-0, 19/00065-1, 18/07087-8, 16/03572-3, 15/23376-1, 15/11268-0)
CABRAL, LAIS M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.; FALQUETTO, BARBARA. Attenuated baroreflex in a Parkinson's disease animal model coincides with impaired activation of non-C1 neurons. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 225, . (15/11268-0, 16/08987-7, 15/23376-1, 16/23281-3)
SILVA, JOSIANE N.; OLIVEIRA, LUIZ M.; SOUZA, FELIPE C.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Distinct pathways to the parafacial respiratory group to trigger active expiration in adult rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, v. 317, n. 3, p. L402-L413, . (15/23376-1, 16/23281-3, 14/23418-3)
AQUINO, YASMIN C.; CABRAL, LAIS M.; MIRANDA, NICOLE C.; NACCARATO, MONIQUE C.; FALQUETTO, BARBARA; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Respiratory disorders of Parkinson's disease. Journal of Neurophysiology, v. 127, n. 1, p. 1-15, . (15/23376-1, 20/16320-8, 19/00065-1, 19/01236-4)
FERREIRA, CAROLINE B.; SILVA, TALITA M.; SILVA, PHELIPE E.; CASTRO, CLAUDIO L.; CZEISLER, CATHERINE; OTERO, JOSE J.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia. eLIFE, v. 11, p. 23-pg., . (15/23376-1)
MOREIRA, THIAGO S.; SHI, YINGTANG; SOBRINHO, CLEYTON R.; MILLA, BRENDA M.; SOTA-PEREZ, JASEPH; STORNETTA, DANIEL S.; STORNETTA, RUTH L.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; BAYLISS, DOUGLAS A.. 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity. FASEB JOURNAL, v. 36, p. 1-pg., . (19/01236-4, 15/23376-1)
OLIVEIRA, LUIZ M.; FERNANDES-JUNIOR, SILVIO A.; CABRAL, LAIS M. C.; MIRANDA, NICOLE C. S.; CZEISLER, CATHERINE M.; OTERO, JOSE J.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Regulation of blood vessels by ATP in the ventral medullary surface in a rat model of Parkinson's disease. Brain Research Bulletin, v. 187, p. 17-pg., . (15/23376-1, 17/11165-1, 19/09323-3, 14/20695-6, 19/01236-4)
NASCIMENTO, ANDRE L. F.; MEDEIROS, PAMELA O. S.; PEDRAO, LUIZ F. A. T.; QUEIROZ, VITORIA C.; OLIVEIRA, LUIZ M.; NOVAES, LEONARDO S.; CAETANO, ARIADINY L.; MUNHOZ, CAROLINA D.; TAKAKURA, ANA C.; FALQUETTO, BARBARA. Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson's Disease. Neuroscience, v. 502, p. 16-pg., . (15/23376-1, 19/00065-1, 16/03572-3, 19/01236-4)
LIMA, JANAYNA D.; SOBRINHO, CLEYTON R.; FALQUETTO, BARBARA; SANTOS, LEONARDO K.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. Cholinergic neurons in the pedunculopontine tegmental nucleus modulate breathing in rats by direct projections to the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, v. 597, n. 7, p. 1919-1934, . (15/23376-1, 16/23281-3, 15/12827-2, 16/22069-0, 17/01380-2)
FALQUETTO, BARBARA; OLIVEIRA, LUIZ M.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. Inhibition of the hypercapnic ventilatory response by adenosine in the retrotrapezoid nucleus in awake rats. Neuropharmacology, v. 138, p. 47-56, . (15/23376-1, 16/23281-3, 16/22069-0)
CLEARY, COLIN M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.; NELSON, MARK T.; LONGDEN, THOMAS A.; MULKEY, DANIEL K.. Vascular control of the CO2/H+-dependent drive to breathe. eLIFE, v. 9, p. 23-pg., . (16/23281-3, 15/23376-1)
MOREIRA, THIAGO S.; TAKAKURA, ANA C.; COLOMBARI, EDUARDO. Editorial: Integrative Physiology: Systemic Hypertension and Respiratory-Sympathetic Coupling. FRONTIERS IN PHYSIOLOGY, v. 13, p. 3-pg., . (15/23376-1, 15/23467-7, 19/01236-4)
LIMA, JULIANA C.; OLIVEIRA, LUIZ M.; BOTELHO, MARINA T.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. The involvement of the pathway connecting the substantia nigra, the periaqueductal gray matter and the retrotrapezoid nucleus in breathing control in a rat model of Parkinson's disease. Experimental Neurology, v. 302, p. 46-56, . (14/22406-1, 16/23281-3, 15/23376-1, 15/18842-3, 13/00103-4)
OLIVEIRA, LUIZ M.; MOREIRA, THIAGO S.; TAKAKURA, ANA C.. Raphe Pallidus is Not Important to Central Chemoreception in a Rat Model of Parkinson's Disease. Neuroscience, v. 369, p. 350-362, . (15/18842-3, 16/23281-3, 14/22406-1, 15/23376-1)
SILVA, TALITA M.; CHAAR, LAIALI J.; SILVA, REINALDO C.; TAKAKURA, ANA C.; CAMARA, NIELS O.; ANTUNES, VAGNER R.; MOREIRA, THIAGO S.. Minocycline alters expression of inflammatory markers in autonomic brain areas and ventilatory responses induced by acute hypoxia. Experimental Physiology, v. 103, n. 6, p. 884-895, . (15/23376-1, 16/23281-3, 16/22069-0, 16/21991-3, 13/00401-5)

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