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Male reproductive parameters of rats exposed perinatally to Ibuprofen: morphological, seminal, behavioral and molecular aspects.

Grant number: 16/12110-3
Support Opportunities:Regular Research Grants
Duration: December 01, 2016 - November 30, 2018
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Arielle Cristina Arena
Grantee:Arielle Cristina Arena
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated researchers:Daniela Cristina Ceccatto Gerardin ; Rafael Henrique Nóbrega

Abstract

Prostaglandins (PGE2) are essential in the process of hypothalamic sexual differentiation, promoting the masculinization of hypothalamus in males. The non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (third class of drugs most used by pregnant) act through non-selective inhibition of COX-1 and 2, with the reduction of PGE2. Thus, when used during pregnancy, these substances are able to compromise the hypothalamic differentiation process. This study will evaluate the effects of perinatal exposure to ibuprofen and possible late on reproductive parameters in adult male rats. Pregnant rats will be exposed to three doses of ibuprofen (10; 25; 50 mg/kg) from last week of pregnancy (Gestational days 15-21) to the end of lactation (Postnatal day 20) by gavage. During the treatment, some maternal parameters, such as toxicity signs, behavior, biochemical and hematological analyses will be evaluated. After birth, the male offspring will be assessed using the following parameters: determination of body weight, anogenital distance and ages of preputial separation and testicular descent. In adulthood, these same animals will be investigated regarding weights of reproductive organs, sperm parameters, hormonal dosage, histology of testis, epididymis, pituitary and hypothalamus, sexual behavior, fertility test, volume of the sexually dimorphic nucleus of the preoptic area and quantitative gene expression in real time in hypothalamus genes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BALIN, PAOLA DA SILVA; JORGE, BARBARA CAMPOS; RIBEIRO LEITE, ANDRESSA REJANI; BORGES, CIBELE SANTOS; OBA, EUNICE; RAMO SILVA, ERICK JOSE; DE BARROS, ALINE LIMA; CASTRO HORTA-JUNIOR, JOSE DE ANCHIETA; ARENA, ARIELLE CRISTINA. Maternal exposure to ibuprofen can affect the programming of the hypothalamus of the male offspring. REGULATORY TOXICOLOGY AND PHARMACOLOGY, v. 111, . (16/12110-3)
JORGE, BARBARA CAMPOS; BALIN, PAOLA DA SILVA; CARNEIRO, GIOVANNA DE BRITO; BELLETI, RAFAEL; CASALI REIS, ANA CAROLINA; STEIN, JULIA; DE BARROS, ALINE LIMA; LEITE KASSUYA, CANDIDA APARECIDA; ARENA, ARIELLE CRISTINA. Ibuprofen compromises sexual behavior and fertility in female rats exposed during the perinatal period. TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, v. 102, n. 9, p. 490-505, . (17/03997-7, 16/12110-3)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.