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Development of calcium phosphate nanoparticles functionalized with acidic monomers for dental remineralization

Grant number: 16/50321-6
Support type:Regular Research Grants
Duration: January 01, 2017 - December 31, 2018
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Cooperation agreement: University of Sydney
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal researcher:Roberto Ruggiero Braga
Grantee:Roberto Ruggiero Braga
Principal researcher abroad: Ramin Rohanizadeh
Institution abroad: University of Sydney, Australia
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/15019-4 - Development of functionalized calcium phosphate nanoparticles for use in resin-based dental composites, AP.R

Abstract

Calcium phosphate (CaP) nanoparticles functionalization with ethylene glycol dimethacrylete derivatives does not reduce agglomeration. Therfore, alternative strategies are necessary in order to stabilize the nanoparticles and prevent agglomeration, while creating reactive sites to improve the interaction with the composite resin matrix. Citric acid has been used as nanoparticle stabilizer due to its three carboxylic groups, which increase the surface charge of the particles. Methacrylate monomers containing phosphoric acid groups also present one or two negatively charged sites, potentially capable of reducing nanoparticle agglomeration. This project has the purpose of investigating the effect of different organic functionalizing agents on CaP nanoparticles formation and test these particles as ion-releasing fillers in experimental resin-based composites. Experimental composites will be evaluated for mechanical properties, ion release and their efficacy in reducing mineral loss of enamel exposed to acidic challenge. The hypothesis is that negatively charged organic molecules (such as citric acid, acrylic acid and methacryloyloxyethyl phosphate) will contribute to reduce nanoparticle agglomeration, while those also presenting polymerizable vinyl groups (acrylic acid and MOEP) will present a stronger interaction with the composite resin matrix. DEGDMA will also be tested, as it has shown the most promising results on the undergoing project testing different EGDMA derivatives. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHIARI, MARINA D. S.; RODRIGUES, MARCELA C.; PINTO, MIRELLA F. C.; VIEIRA, DOUGLAS N.; VICHI, FLAVIO M.; VEGA, OSCAR; CHRZANOWSKI, WOJCIECH; NAGAOKA, NORIYUKI; BRAGA, ROBERTO R. Development of brushite particles synthesized in the presence of acidic monomers for dental applications. Materials Science & Engineering C-Materials for Biological Applications, v. 116, NOV 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.