Advanced search
Start date

Influence of moment of systemic metronidazole and amoxicillin administration in the treatment of chronic periodontitis

Grant number: 16/10958-5
Support Opportunities:Regular Research Grants
Duration: September 01, 2016 - June 30, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Magda Feres Figueiredo
Grantee:Magda Feres Figueiredo
Host Institution: Universidade Universus Veritas Guarulhos (Univeritas UNG). Guarulhos , SP, Brazil
Associated researchers:Cláudio Mendes Pannuti ; Giuseppe Alexandre Romito ; Luciene Cristina de Figueiredo ; Marcelo de Faveri ; Maria Josefa Mestnik


The combination of systemic metronidazole (MTZ) and amoxicillin (AMX) to scaling and root planing (SRP) has shown to be a promising periodontal treatment. However, some essential issues associated with the use of these antibiotics remain to be established. Although these agents are often prescribed after the healing phase of the SRP procedure, there is biological plausibility to support its use in conjunction with the mechanical treatment. However, to date, no placebo controlled randomized clinical trial (RCT) has directly compared these two protocols. Therefore, the aim of this multicenter RCT is to compare the clinical and microbiological effects of the adjunctive use of systemic MTZ+AMX administered in different phases of the treatment of generalized chronic periodontitis (GChP). 180 subjects with GChP will be randomly assigned into three groups (n=60/group) that will receive RAR-only (control group) or in combination with 400 mg MTZ+500 mg AMX beginning with the first RAR session (test 1 group) or after the healing phase (test 2 group). All volunteers will be evaluated clinically and microbiologically at baseline, 3, 6 and 12 months post-therapy. Nine subgingival biofilm samples will be collected by subject and analyzed for levels and proportions of 40 bacterial species by technical checkerboard DNA-DNA hybridization. Differences in clinical and microbiological parameters among each group and experimental times will be evaluated using the ANOVA, ANCOVA, Chi-square and Tukey. Microbiological analyzes will be performed using adjustments for multiple comparisons. Statistical significance will be set at 5%. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERES, MAGDA; RETAMAL-VALDES, BELEN; MESTNIK, MARIA JOSEFA; DE FIGUEIREDO, LUCIENE CRISTINA; FAVERI, MARCELO; DUARTE, POLIANA M.; FRITOLI, ARETUZA; FAUSTINO, ELISANGELA; SILVEIRA SOUTO, MARIA LUISA; RODRIGUES, MICHELLE DE FRANCO; et al. The ideal time of systemic metronidazole and amoxicillin administration in the treatment of severe periodontitis: study protocol for a randomized controlled trial. Trials, v. 19, . (16/10958-5)

Please report errors in scientific publications list by writing to: