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Leaves and stalks of beet (Beta vulgaris L.): characterization and effects of the antioxidant capacity in obese and dyslipidemic

Abstract

In Brazil, the incidence of obesity in all age groups has been growing, and it has serious consequences to health. Recent evidence suggests that oxidative stress may be an important component involved in the complications associated with obesity. The oxidation of the LDL particle is a factor that is associated with the development of atherosclerosis, one of the complications involved in cardiovascular disorders commonly present in patients with obesity. Bioactive compounds in foods exhibit anti-inflammatory and antioxidant properties. The leaves and stems of beet has showed higher total phenolic contents that the root. Some phenolic compounds such as betaninas, quercetin and myricetin are potent agents that can reduce and / or inhibit oxidation of LDL cholesterol, reducing changes in endothelial structure. This study aims to characterize and evaluate the antioxidant potential of leaves and stems beet freeze-dried, and study the antioxidant effect of the leaves and stems beet in obese with dyslipidemia volunteers. For this, we performed the following analysis: physicochemical and microbial characterization; identification by chromatographic methods major bioactive compounds; evaluation of the antioxidant capacity by in vitro methods (ABTS, ORAC, inhibition of LDL oxidation) and in cell culture; evaluation of the use of leaves and stems beet lyophilized as adjunctive therapy in the treatment of dyslipidemia associated with obesity by double-blind clinical study in obese patients treated at AME / Limeira, SP (AU)

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VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALVINO DA SILVA, LUIZ GUILHERME; MORELLI, ANA PAULA; BETIM PAVAN, ISADORA CAROLINA; TAVARES, MARIANA ROSOLEN; PESTANA, NATHALIE FORTES; ROSTAGNO, MAURICIO ARIEL; SIMABUCO, FERNANDO MOREIRA; NEVES BEZERRA, ROSANGELA MARIA. Protective effects of beet (Beta vulgaris) leaves extract against oxidative stress in endothelial cells in vitro. Phytotherapy Research, v. 34, n. 6, . (16/06457-0, 12/13558-7, 13/04304-4, 18/14818-9)
MORELLI, ANA PAULA; TORTELLI, THARCISIO CITRANGULO JR JR; BETIM PAVAN, ISADORA CAROLINA; SILVA, FERNANDO RIBACK; GRANATO, DANIELA CAMPOS; PERUCA, GUILHERME FRANCISCO; PAULETTI, BIANCA ALVES; DOMINGUES, ROMENIA RAMOS; NEVES BEZERRA, ROSANGELA MARIA; DE MOURA, LEANDRO PEREIRA; et al. Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways. International Journal of Oncology, v. 58, n. 6, . (16/02483-7, 19/00607-9, 15/22814-5, 17/04269-5, 15/16601-9, 18/14818-9, 16/06457-0, 12/13558-7)
ROMERO, STEFHANI ANDRIOLI; BETIM PAVAN, ISADORA CAROLINA; MORELLI, ANA PAULA; SILVA MANCINI, MARIANA CAMARGO; SALVINO DA SILVA, LUIZ GUILHERME; FAGUNDES, ISABELLA; ROCHA SILVA, CAYO HENRIQUE; SABOIA PONTE, LUIS GUSTAVO; ROSTAGNO, MAURICIO ARIEL; NEVES BEZERRA, ROSANGELA MARIA; et al. Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa). Phytotherapy Research, v. 35, n. 11, . (18/14818-9, 16/06457-0, 19/25582-9, 15/00311-1, 19/00607-9, 19/13848-4)
SILVA MANCINI, MARIANA CAMARGO; SABOIA PONTE, LUIS GUSTAVO; ROCHA SILVA, CAYO HENRIQUE; FAGUNDES, ISABELLA; BETIM PAVAN, ISADORA CAROLINA; ROMEIRO, STEFHANI ANDRIOLI; SALVINO DA SILVA, LUIZ GUILHERME; MORELLI, ANA PAULA; ROSTAGNO, MAURICIO ARIEL; SIMABUCO, FERNANDO MOREIRA; et al. Beetroot and leaf extracts present protective effects against prostate cancer cells, inhibiting cell proliferation, migration, and growth signaling pathways. Phytotherapy Research, . (18/14818-9, 16/06457-0, 19/25582-9, 15/00311-1, 19/00607-9, 19/13848-4)
SUMERE, BEATRIZ ROCCHETTI; DE SOUZA, MARIANA CORREA; DOS SANTOS, MARIANA PACIFICO; NEVES BEZERRA, ROSANGELA MARIA; DA CUNHA, DIOGO THIMOTEO; MARTINEZ, JULIAN; ROSTAGNO, MAURICIO ARIEL. Combining pressurized liquids with ultrasound to improve the extraction of phenolic compounds from pomegranate peel (Punica granatum L.). ULTRASONICS SONOCHEMISTRY, v. 48, p. 151-162, . (16/19930-6, 15/11932-7, 16/06457-0, 16/20016-7)
CHAVES, FERNANDA MACHADO; BETIM PAVAN, ISADORA CAROLINA; SALVINO DA SILVA, LUIZ GUILHERME; DE FREITAS, LIDIA BROGLIO; ROSTAGNO, MAURICIO ARIEL; COSTA ANTUNES, ADRIANE ELISABETE; NEVES BEZERRA, ROSANGELA MARIA; SIMABUCO, FERNANDO MOREIRA. Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway. PLANT FOODS FOR HUMAN NUTRITION, v. 75, n. 1, p. 54-62, . (15/07299-7, 18/14818-9, 16/06457-0, 12/13558-7, 13/04304-4)
TAVARES, MARIANA ROSOLEN; LEMES, SIMONE FERREIRA; DE FANTE, THAIS; DE MIERA, CRISTINA SAENZ; BETIM PAVAN, ISADORA CAROLINA; NEVES BEZERRA, ROSANGELA MARIA; PRADA, PATRICIA OLIVEIRA; TORSONI, MARCIO ALBERTO; ELIAS, CAROL FUZETI; SIMABUCO, FERNANDO MOREIRA. Modulation of hypothalamic S6K1 and S6K2 alters feeding behavior and systemic glucose metabolism. Journal of Endocrinology, v. 244, n. 1, p. 71-82, . (12/13558-7, 13/22696-7, 18/14818-9, 18/07018-6, 15/24475-3, 16/06457-0)
CAETANO-SILVA, MARIA ELISA; SIMABUCO, FERNANDO MOREIRA; NEVES BEZERRA, ROSANGELA MARIA; DA SILVA, DANIELE CRISTINA; BARBOSA, EDER ALVES; MOREIRA, DANIEL CARNEIRO; BRAND, GUILHERME DOTTO; DE SOUZA DE ALMEIDA LEITE, JOSE ROBERTO; BERTOLDO PACHECO, MARIA TERESA. Isolation and Sequencing of Cu-, Fe-, and Zn-Binding Whey Peptides for Potential Neuroprotective Applications as Multitargeted Compounds. Journal of Agricultural and Food Chemistry, v. 68, n. 44, p. 12433-12443, . (18/14818-9, 17/16977-4, 16/06457-0)
SILVA MANCINI, MARIANA CAMARGO; SABOIA PONTE, LUIS GUSTAVO; ROCHA SILVA, CAYO HENRIQUE; FAGUNDES, ISABELLA; BETIM PAVAN, ISADORA CAROLINA; ROMEIRO, STEFHANI ANDRIOLI; SALVINO DA SILVA, LUIZ GUILHERME; MORELLI, ANA PAULA; ROSTAGNO, MAURICIO ARIEL; SIMABUCO, FERNANDO MOREIRA; et al. Beetroot and leaf extracts present protective effects against prostate cancer cells, inhibiting cell proliferation, migration, and growth signaling pathways. Phytotherapy Research, v. 35, n. 9, p. 5241-5258, . (19/13848-4, 18/14818-9, 16/06457-0, 15/00311-1, 19/25582-9, 19/00607-9)

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