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AT1R internalization and Ras/Raf/MEK/ERK signaling in the cardiomyocyte hypertrophy induced by thyroid hormone. role of beta-arrestins

Grant number: 16/13896-0
Support Opportunities:Regular Research Grants
Duration: February 01, 2017 - July 31, 2019
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Maria Luiza de Morais Barreto de Chaves
Grantee:Maria Luiza de Morais Barreto de Chaves
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Thyroid Hormones (TH) exert numerous effects in the cardiovascular system.In this way, the hyperthyroidism is associated to elevated cardiac function and morphologic alterations in the heart as cardiac hypertrophy. We have described that the increase of cardiac mass induced by TH is mediated, at least in part by activation of Renin-Angiotensin System, mainly by AT1 Receptor (AT1R). This receptor when activated may stimulate two different mechanims of signaling: mechanism G- protein dependent or G-protein independent, mediated by beta-arrestins. Herein we will evaluate the contribution of beta-arrestins and Raf/MEK/ERK pathway signaling in the cardiomyocyte hypertrophy indeced by TH. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LINO, CAROLINE ANTUNES; DE BORTOLI TEIXEIRA, LARISSA; CAPELUPE SIMOES, SARAH; DE OLIVEIRA SILVA, TABATHA; DINIZ, GABRIELA PLACONA; DA COSTA-NETO, CLAUDIO MIGUEL; BARRETO-CHAVES, MARIA LUIZA MORAIS. Beta-arrestin 2 mediates cardiac hypertrophy induced by thyroid hormones via AT1R. Journal of Cellular Physiology, v. 236, n. 6, . (16/13896-0, 13/16142-9)
SENGER, NATHALIA; C. PARLETTA, ALINE; MARQUES, BRUNO V. D.; AKAMINE, ELIANA H.; DINIZ, GABRIELA P.; CAMPAGNOLE-SANTOS, MARIA J.; SANTOS, ROBSON A. S.; BARRETO-CHAVES, MARIA LUIZA M.. Angiotensin-(1-7) prevents T3-induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF-x138;B. Journal of Cellular Physiology, v. 236, n. 4, p. 3059-3072, . (16/13896-0)
BARRETO-CHAVES, M. L. M.; SENGER, N.; FEVEREIRO, M. R.; PARLETTA, A. C.; TAKANO, A. P. C.. Impact of hyperthyroidism on cardiac hypertrophy. ENDOCRINE CONNECTIONS, v. 9, n. 3, p. R59-R69, . (16/13896-0)
LINO, CAROLINE ANTUNES; BARRETO-CHAVES, MARIA LUIZA. Beta-arrestins in the context of cardiovascular diseases: Focusing on angiotensin II type 1 receptor (AT1R). CELLULAR SIGNALLING, v. 92, p. 9-pg., . (13/16142-9, 16/13896-0)
BARRETO-CHAVES, M. L. M.; SENGER, N.; FEVEREIRO, M. R.; PARLETTA, A. C.; TAKANO, A. P. C.. Impact of hyperthyroidism on cardiac hypertrophy. ENDOCRINE CONNECTIONS, v. 9, n. 3, p. 11-pg., . (16/13896-0)
LINO, CAROLINE ANTUNES; MORAIS BARRETO-CHAVES, MARIA LUIZA. Contribution of Beta-Arrestin Signaling on Thyroid Hormone-Induced Cardiac Hypertrophy. FASEB JOURNAL, v. 31, p. 1-pg., . (16/13896-0, 13/16142-9)

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