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Pre-clinical studies with Agaricus blazei, Lentinula edodes and Ganoderma lucidum, aiming to reduce the maternal and fetal damage caused by gestational diabetes.

Grant number: 15/24566-9
Support Opportunities:Regular Research Grants
Duration: August 01, 2016 - January 31, 2019
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Marli Gerenutti
Grantee:Marli Gerenutti
Host Institution: Pró-Reitoria Acadêmica. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil
Associated researchers:Angela Faustino Jozala ; Denise Grotto


The growing trend of gestational diabetes mellitus risk is associated with increased risk of morbidity and maternal and perinatal mortality. Children of mothers with gestational diabetes untreated are at risk for intrauterine death, heart and breathing problems, jaundice and episodes of hypoglycemia after delivery. Also, after the development of gestational diabetes, women are more susceptible to developing diabetes throughout his life. The nutritional intervention appears to be an important factor in the control of this diabetes, and it may bring potential benefits for maternal and fetal health. Aim: Check possible reduction of moderate gestational diabetes damage in rats, at exposure to three species of edible mushrooms, considering their nutritional potential. Methods: Perinatal assessment techniques will be employed in daily maternal exposure to lyophilized powders from Agaricus balzei, Lentinula edodes or Ganoderma lucidum before or after the induction of pregnancy type 2 diabetes with streptozotocin (single dose of 40 mg/kg, IP.); will be performed (1) biochemical evaluations and oxidative stress placenta, amniotic fluid and maternal blood; (2) Oral glucose maternal tolerance test and insulin dosages; (3) evaluation of embryofetal development. Results: How is a pre-clinical trial, we intend to use these parameters to infer on the potential benefits of exposure to Lentinula edodes, the Agaricus blazei and Ganoderma lucidum rats during gestation period with moderate DMG. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAETANO, ERIKA LEAO AJALA; VIROEL, FABIA JUDICE MARQUES; LAURINO, LETICIA FAVARA; CAMARGO, ISABELLA FERREIRA; CASTRO, RAQUEL DE MENDONCA ROSA; PICKLER, THAISA BORIM; JOZALA, ANGELA FAUSTINO; GROTTO, DENISE; GERENUTTI, MARLI. Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes) as a Functional Food in Gestational Diabetes Mellitus Before and After Fetus Implantation. International Journal of Medicinal Mushrooms, v. 23, n. 9, p. 15-27, . (15/24566-9, 13/05765-5)
MASCHIO, BIANCA HESSEL; GENTIL, BIANCA CARVALHO; AJALA CAETANO, ERIKA LEAO; RODRIGUES, LUCAS SILVA; LAURINO, LETICIA FAVARA; VIEIRA SPIM, SARA ROSICLER; JOZALA, ANGELA FAUSTINO; DOS SANTOS, CAROLINA ALVES; GROTTO, DENISE; GERENUTTI, MARLI. Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats. International Journal of Medicinal Mushrooms, v. 19, n. 11, p. 991-1000, . (15/24566-9, 13/05765-5)
LAURINO, LETICIA F.; VIROEL, FABIA J. M.; CAETANO, ERIKA; SPIM, SARA; PICKLER, THAISA B.; ROSA-CASTRO, RAQUEL M.; VASCONCELOS, EDILMA ALBUQUERQUE; JOZALA, ANGELA F.; HATAKA, ALESSANDRE; GROTTO, DENISE; et al. Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus. NUTRIENTS, v. 11, n. 11, . (15/24566-9, 13/05765-5)
CAMARGO, ISABELLA FERREIRA; AJALA GAETANO, ERIKA LEAO; PICKLER, THAISA BORIM; GERENUTTI, MARLI; GROTTO, DENISE. Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): Absence of Changes in Maternal Reproductive Performance and Embryofetal Development In Vivo. International Journal of Medicinal Mushrooms, v. 22, n. 8, p. 781-792, . (15/24566-9)

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