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Clinical and microbiological evaluation of the peri-implant colonization of cemented-retained restorations on titanium or zirconia abutments


Culture-based and molecular diagnosis methods have been largely used to identify and quantify microbial species harboring several hard and soft tissues of the oral cavity. However, few studies have correlated the impact of microorganisms colonizing oral surfaces on the clinical parameters of dental implants in function. The oral microbiota comprehends a complex ecosystem where up to 700 different microbial species can be found. Most of these species have a synergism and are related to the maintenance of oral tissues health; while other less common species (such as pathogenic and opportunistic species) may be overwhelmed in specific conditions leading to inflammatory reactions, which may compromise the long-term success of dental implants. The aim of this longitudinal controlled study is to compare the microbial biofilm formed into the peri-implant sulci and implant-supported restorations cemented on the titanium or zirconia-based abutments after 12, 24 and 36 of loading in healthy individuals. Data provided by the microbiological analyses from Checkerboard DNA-DNA Hybridization (microbial count) and pyrosequencing of 16S rDNA-based PCR (microbial diversity) will be correlated with clinical parameters assessed by probing depth, bleeding on probing, clinical attachment and marginal bone resorption. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FREITAS, ALICE RAMOS; DEL REY, YUMI CHOKYU; SANTOS, EMERSON DE SOUZA; RIBEIRO, RICARDO FARIA; DE ALBUQUERQUE JUNIOR, RUBENS FERREIRA; DO NASCIMENTO, CASSIO. Microbial communities of titanium versus zirconia abutments on implant-supported restorations: Biodiversity composition and its impact on clinical parameters over a 3-year longitudinal prospective study. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, v. 23, n. 2, . (14/22876-8)
DE OLIVEIRA SILVA, THALISSON S.; DE FREITAS, ALICE R.; DE ALBUQUERQUE JUNIOR, RUBENS F.; PEDRAZZI, VINICIUS; RIBEIRO, RICARDO F.; DO NASCIMENTO, CASSIO. A 3-year longitudinal prospective study assessing microbial profile and clinical outcomes of single-unit cement-retained implant restorations: Zirconia versus titanium abutments. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, v. 22, n. 3, . (14/22876-8)
DE FREITAS, ALICE RAMOS; DE OLIVEIRA SILVA, THALISSON SAYMO; RIBEIRO, RICARDO FARIA; DE ALBUQUERQUE JUNIOR, RUBENS FERREIRA; PEDRAZZI, VINICIUS; DO NASCIMENTO, CASSIO. Oral bacterial colonization on dental implants restored with titanium or zirconia abutments: 6-month follow-up. CLINICAL ORAL INVESTIGATIONS, v. 22, n. 6, p. 2335-2343, . (10/12830-0, 14/22876-8)
RAFFAINI, FLAVIA CORREA; FREITAS, ALICE RAMOS; OLIVEIRA SILVA, THALISSON SAYMO; CAVAGIONI, TARSIS; OLIVEIRA, JESSICA FELIX; ALBUQUERQUE JUNIOR, RUBENS FERREIRA; PEDRAZZI, VINICIUS; RIBEIRO, RICARDO FARIA; DO NASCIMENTO, CASSIO. Genome analysis and clinical implications of the bacterial communities in early biofilm formation on dental implants restored with titanium or zirconia abutments. BIOFOULING, v. 34, n. 2, p. 173-182, . (10/12830-0, 14/22876-8)

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