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Functional study of the miR159- and miR319-regulated pathways during tomato flower and fruit development

Abstract

Small RNAs or sRNAs (19-25 nt) regulate transcriptionally and posttranscriptionally gene expression in plants, modulating their transcriptome and proteome. Among these sRNAs, microRNAs (miRNAs) arise as key regulators of development. MiRNAs are generated from long single-strand RNA molecules (pri-miRNAs) that are processed by different enzymes to produce the mature miRNA. In plants, mature miRNA "guides" the cleavage and/or disturb translation of their mRNA targets. Recently, our research group described the role of the miR156 and their targets in tomato (Solanum lycopersicum) fruit development (Ferreira e Silva et al., 2014) and miR156 evolutionary pattern in land plants (Morea et al., 2016). More recently, by using mutants and transgenic plants, our group identified two evolutionary-related miRNAs (miR319 and miR159), which seem to be involved in carpel development and seedless fruit formation in tomato. Nonetheless, detailed phenotypic and molecular analyzes are necessary to unravel genetic and hormonal pathways regulated by miR319 and miR159 during fruit development. Therefore, this project aims to use a combination of available mutants and transgenic plants, as well as diverse molecular tools, to unravel possible genetic/hormonal pathways that crosstalked and are regulated by these miRNAs and impact tomato reproductive development. The identification and characterization of such pathways should contribute not only for our better understanding of plant development, but also have potential applications in the breeding of tomato and perhaps other Solanaceae species. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARRERA-ROJAS, CARLOS HERNAN; BRAGA ROCHA, GABRIEL HENRIQUE; POLVERARI, LAURA; PINHEIRO BRITO, DIEGO ARMANDO; BATISTA, DIEGO SILVA; NOTINI, MARCELA M.; FERREIRA DA CRUZ, ANA CLAUDIA; ORTIZ MOREA, EDNA GICELA; SABATINI, SABRINA; OTONI, WAGNER CAMPOS; SILVEIRA NOGUEIRA, FABIO TEBALDI. miR156-targeted SPL10 controls Arabidopsis root meristem activity and root-derived de novo shoot regeneration via cytokinin responses. Journal of Experimental Botany, v. 71, n. 3, p. 934-950, JAN 23 2020. Web of Science Citations: 0.
SILVA, GERALDO F. F.; SILVA, EDER M.; CORREA, JOAO P. O.; VICENTE, MATEUS H.; JIANG, NAN; NOTINI, MARCELA M.; JUNIOR, AIRTON C.; DE JESUS, FREDERICO A.; CASTILHO, POLLYANNA; CARRERA, ESTHER; LOPEZ-DIAZ, ISABEL; GROTEWOLD, ERICH; PERES, LAZARO E. P.; NOGUEIRA, FABIO T. S. Tomato floral induction and flower development are orchestrated by the interplay between gibberellin and two unrelated microRNA-controlled modules. NEW PHYTOLOGIST, v. 221, n. 3, p. 1328-1344, FEB 2019. Web of Science Citations: 8.
DE OLIVEIRA CORREA, JOAO PAULO; SILVA, EDER M.; NOGUEIRA, FABIO T. S. Molecular Control by Non-coding RNAs During Fruit Development: From Gynoecium Patterning to Fruit Ripening. FRONTIERS IN PLANT SCIENCE, v. 9, NOV 30 2018. Web of Science Citations: 1.
DA SILVA, EDER MARQUES; FERREIRA E SILVA, GERALDO FELIPE; BIDOIA, DEBORA BRUSSOLO; AZEVEDO, MARIANA DA SILVA; DE JESUS, FREDERICO ALMEIDA; PINO, LILIAN ELLEN; PEREIRA PERES, LAZARO EUSTAQUIO; CARRERA, ESTHER; LOPEZ-DIAZ, ISABEL; SILVEIRA NOGUEIRA, FABIO TEBALDI. microRNA159-targeted SIGAMYB transcription factors are required for fruit set in tomato. Plant Journal, v. 92, n. 1, p. 95-109, OCT 2017. Web of Science Citations: 8.

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