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Photosensitization and photodamage of cells and biomimetic models by pterin derivatives

Abstract

Pterins, heterocyclic compounds present in living systems, are well-known type I (electron-transfer) and type II (singlet oxygen) photosensitizers under UVA irradiation. They can photoinduce oxidation of nucleotides, DNA, proteins and membrane lipids. This project aims to study the cellular uptake of dihydrobiopterin, one of the most relevant pterins from a biological point of view, the photoconversion to biopterin and the generation of singlet molecular oxygen and other reactive oxygen species inside the cell, using advanced microscopy techniques, such as Fluorescence Lifetime Imaging Microscopy. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIGNONI, MARIANA; NOEL URRUTIA, MARIA; JUNQUEIRA, HELENA C.; GREER, ALEXANDER; REIS, ANA; BAPTISTA, MAURICIO S.; ITRI, ROSANGELA; THOMAS, ANDRES H. Photo-Oxidation of Unilamellar Vesicles by a Lipophilic Pterin: Deciphering Biomembrane Photodamage. Langmuir, v. 34, n. 50, p. 15578-15586, DEC 18 2018. Web of Science Citations: 4.

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