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Mechanisms underkying how social experience alters hormone levels, sensory signaling and behavior

Grant number: 15/50371-0
Support Opportunities:Regular Research Grants
Duration: May 01, 2016 - April 30, 2018
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Convênio/Acordo: Scripps Research Institute
Principal Investigator:Fabio Papes
Grantee:Fabio Papes
Principal researcher abroad: Lisa Stowers
Institution abroad: Scripps Research Institute, San Diego, United States
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Accurately sensing and interpreting social cues is critical to trigger appropriate behavior. It is known that previous social experiences change interpretation of sensory cues from the environment and alter subsequent behavior, either by the influence of memory or by the action of hormones which modulate specific brain networks. Sensory perception and behavioral output in response to social experience fail to occur normally in autistic and schizophrenia patients, yet there is little mechanistic understanding of the function and dysfunction behind this phenomenon. We propose to identify how the molecular mechanisms that translate sensory information into behavior are altered by experience. Specifically, we will study differences in sensory responsivity and neural processing between bachelor male mice that commit infanticide and males that exhibit nurturing parental behavior after social bonding with females. Our preliminary data show that this occurs not in deep brain circuits, but by the direct action of a neuropeptide hormone on olfactory sensory neurons. This hormone silences the detection of sensory cues that trigger infanticide and thereby allow the display of parental behavior. Such mechanism redefines the functional purpose of sensory neurons, from simple external sensors to key integrators and processors of both external and internal stimuli. Our results will enable future study of function and dysfunction of experience on behavior. The study of neural mechanisms of behavior is a systems level question that has proven too difficult for a single research group to tackle. Study of this neglected area by the unique experience and focus of both collaborative groups will ensure the project’s successful completion. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
A smell, a response 
Un aroma, una respuesta 
Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMARGO, ANTONIO P.; NAKAHARA, THIAGO S.; FIRMINO, LUIZ E. R.; NETTO, PAULO H. M.; DO NASCIMENTO, JOAO B. P.; DONNARD, ELISA R.; GALANTE, PEDRO A. F.; CARAZZOLLE, MARCELO F.; MALNIC, BETTINA; PAPES, FABIO. Uncovering the mouse olfactory long non-coding transcriptome with a novel machine-learning model. DNA Research, v. 26, n. 4, p. 365-378, . (11/22611-6, 16/24471-0, 18/11860-4, 16/05379-6, 13/08293-7, 15/50371-0)
DE ANDRADE CARVALHO, VINICIUS MIESSLER; NAKAHARA, THIAGO SEIKE; PAPES, FABIO. Investigation of Activated Mouse Olfactory Sensory Neurons via Combined Immunostaining and in situ Hybridization. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, n. 170, . (12/04026-1, 12/21786-0, 12/01689-0, 14/25594-3, 09/00473-0, 15/50371-0)
NAKAHARA, THIAGO; CAMARGO, ANTONIO; FIRMINO, LUIZ; NETTO, PAULO; DO NASCIMENTO, JOAO; DONNARD, ELISA; GALANTE, PEDRO; CARAZZOLLE, MARCELO; MALNIC, BETTINA; PAPES, FABIO. Uncovering long non-coding RNAs in the olfactory sensory organs. CHEMICAL SENSES, v. 45, n. 2, p. 2-pg., . (16/24471-0, 15/50371-0, 18/11860-4, 11/22611-6, 16/05379-6)
DE ANDRADE CARVALHO, VINICIUS MIESSLER; NAKAHARA, THIAGO SEIKE; DE ANDRADE SOUZA, MATEUS AUGUSTO; CARDOZO, LEONARDO MINETE; TRINTINALIA, GUILHERME ZIEGLER; PISSINATO, LEONARDO GRANATO; VENANCIO, JOSE OTAVIO; STOWERS, LISA; PAPES, FABIO. Representation of Olfactory Information in Organized Active Neural Ensembles in the Hypothalamus. CELL REPORTS, v. 32, n. 8, . (10/01211-7, 12/04026-1, 13/03372-6, 15/50371-0, 12/01689-0, 14/25594-3, 09/00473-0)
IBARRA-SORIA, XIMENA; NAKAHARA, THIAGO S.; LILUE, JINGTAO; JIANG, YUE; TRIMMER, CASEY; SOUZA, MATEUS A. A.; NETTO, PAULO H. M.; IKEGAMI, KENTARO; MURPHY, NICOLLE R.; KUSMA, MAIRI; et al. Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated. eLIFE, v. 6, . (09/00473-0, 15/50371-0)
NAKAHARA, THIAGO S.; CAMARGO, ANTONIO P.; MAGALHAES, PEDRO H. M.; SOUZA, MATEUS A. A.; RIBEIRO, PEDRO G.; MARTINS-NETTO, PAULO H.; CARVALHO, VINICIUS M. A.; JOSE, JULIANA; PAPES, FABIO. Peripheral oxytocin injection modulates vomeronasal sensory activity and reduces pup-directed aggression in male mice. SCIENTIFIC REPORTS, v. 10, n. 1, . (16/05379-6, 15/50371-0, 13/03372-6, 12/21786-0, 16/03641-5, 12/04026-1, 17/01571-2)
NAKAHARA, THIAGO SEIKE; CARVALHO, VINICIUS MIESSLER DE ANDRADE; SOUZA, MATEUS AUGUSTO DE ANDRADE; TRINTINALIA, GUILHERME ZIEGLER; PAPES, FABIO. Detection of Activated Mouse Neurons with Temporal Resolution via Dual c-Fos Staining. STAR PROTOCOLS, v. 1, n. 3, p. 27-pg., . (12/01689-0, 13/03372-6, 15/50371-0, 09/00473-0, 14/25594-3, 12/21786-0, 12/04026-1)
DE ANDRADE CARVALHO, VINICIUS MIESSLER; NAKAHARA, THIAGO SEIKE; PAPES, FABIO. Investigation of Activated Mouse Olfactory Sensory Neurons via Combined Immunostaining and in situ Hybridization. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, v. N/A, n. 170, p. 16-pg., . (12/01689-0, 15/50371-0, 09/00473-0, 14/25594-3, 12/21786-0, 12/04026-1)

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