Advanced search
Start date

The role of lysine(K)-deacetylases on mitochondrial disorders's neuroprotection: perspectives of epigenetic therapy for amyotrophic lateral sclerosis and schizophrenia


Because lysine(K)-deacetylases (KDACs) regulate proteins involved in mechanisms such as gene transcription, cellular clearance and metabolism, in which mitochondria plays an essential role, the aim of this project is to characterize the role of KDACs on mitochondrial function and degradation (mitophagy) in different models of Amyotrophic Lateral Sclerosis (ALS) and Schizophrenia (SHZ); it is known that mitochondria is related to the etiology and/or progression of these disorders. In addition, it is described that KDACs being the main responsible for epigenetic modification, it becomes the major key between molecular events and behavioral alterations; therefore, it will be also evaluated the role of KDACs as neuroprotective agents. To reach the goals proposed herein, neurons and astrocytes from hSOD1 G93A and SHR rats and immortalized cells in the presence or absence of mutant SOD1 and DISC-1 will be treated with different KDACs modulators and/or will be transfected with plasmids, si- or shRNAs against specifics KDACs. Thus, it is expected that this project discloses the neuroprotection role of KDAC in the two major brain cellular types and, as a consequence, new therapeutic tools could be developed. Hence, epigenetic modifications against mitochondrial dysfunction may possibly be the target of future projects (GraphAbstract - ATTACHMENT I). (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VARGA, THIAGO GARCIA; DE TOLEDO SIMOES, JUAN GUILHERME; SIENA, AMANDA; HENRIQUE, ELISANDRA; DA SILVA, REGINA CLAUDIA BARBOSA; DOS SANTOS BIONI, VINICIUS; RAMOS, ALINE CAMARGO; ROSENSTOCK, TATIANA ROSADO. Haloperidol rescues the schizophrenia-like phenotype in adulthood after rotenone administration in neonatal rats. Psychopharmacology, v. 238, n. 9, p. 2569-2585, . (19/17725-4, 15/02041-1, 15/26820-0)
ARAUJO, BEATRIZ GRISOLIA; SOUZA E SILVA, LUIZ FELIPE; TORRESI, JORGE LUIZ DE BARROS; SIENA, AMANDA; VALERIO, BERENICE CATALDO OLIVEIRA; BRITO, MARIANA DUTRA; ROSENSTOCK, TATIANA ROSADO. Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research. Molecular Neurobiology, . (15/02041-1, 18/09084-6, 15/25595-2, 16/12039-7)
BRITO, MARIANA DUTRA; GOMES DA SILVA, GUSTAVO FERRO; TILIERI, ERICK MUTTI; ARAUJO, BEATRIZ GRISOLIA; CALIO, MICHELE LONGONI; ROSENSTOCK, TATIANA ROSADO. Metabolic Alteration and Amyotrophic Lateral Sclerosis Outcome: A Systematic Review. FRONTIERS IN NEUROLOGY, v. 10, . (15/02041-1, 16/12039-7, 18/09084-6)
SOUZA E SILVA, LUIZ FELIPE; BRITO, MARIANA DUTRA; CAMARGO YUZAWA, JESSICA MAYUMI; ROSENSTOCK, TATIANA ROSADO. Mitochondrial Dysfunction and Changes in High-Energy Compounds in Different Cellular Models Associated to Hypoxia: Implication to Schizophrenia. SCIENTIFIC REPORTS, v. 9, . (15/02041-1, 16/12039-7, 15/25595-2)
CALIO, MICHELE LONGONI; HENRIQUES, ELISANDRA; SIENA, AMANDA; BERTONCINI, CLELIA REJANE ANTONIO; GIL-MOHAPEL, JOANA; ROSENSTOCK, TATIANA ROSADO. Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment. FRONTIERS IN NEUROSCIENCE, v. 14, . (15/02041-1)
SIENA, AMANDA; YUZAWA, JESSICA MAYUMI CAMARGO; RAMOS, ALINE CAMARGO; HENRIQUE, ELISANDRA; BRITO, MARIANA DUTRA; CALVAZARA, MARIANA BENDLIN; ROSENSTOCK, TATIANA ROSADO. Neonatal Rotenone Administration Induces Psychiatric Disorder-Like Behavior and Changes in Mitochondrial Biogenesis and Synaptic Proteins in Adulthood. Molecular Neurobiology, v. 58, n. 7, p. 3015-3030, . (16/12039-7, 15/02041-1)

Please report errors in scientific publications list by writing to: