The widespread use of antimicrobial drugs has contributed to the emergence of microorganisms resistant to conventional drugs and comprising a public health problem worldwide because infections caused by micro-organisms resulting in increased mortality and morbidity populations. Investigations for new antimicrobial agents which are effective and less susceptible to bacterial resistance as compounds originating from plants, bacteriocins and antimicrobial peptides apply this demand. Establish an antimicrobial mechanism by which gives the action of a particular product is extremely complex due to a multitude of possibilities of action in the constitution and in the bacterial metabolism. Many tools can be used jointly to elucidate the antimicrobial activity of natural compounds such as, for example, electronic microscopy, membrane permeability analysis, genomics, flow cytometry and proteomic analysis. The aim of this project is to advance the knowledge of the antibacterial action of natural compounds such as essential oils, bacteriocins and bee products, in order to combat major pathogenic bacteria causing infectious diseases, many of them resistant to conventional drugs. Thereby elucidating the impact that these natural compounds cause in bacterial cells. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
CRULHAS, BRUNO PEREIRA;
BERGAMO ALVES, FERNANDA CRISTINA;
MARQUES PEREIRA, ANA FLAVIA;
MURBACH TELES ANDRADE, BRUNA FERNANDA;
BARBOSA, LIDIANE NUNES;
DA SILVEIRA LYRA, LUCIANA PUPO;
MORES RALL, VERA LUCIA;
FERNANDES JUNIOR, ARY.
Antibacterial and anti-biofilm activities of cinnamaldehyde against S. epidermidis.
Web of Science Citations: 3.