Advanced search
Start date
Betweenand

Elucidating the role of the innate immune complement pathway in brain development and in Autism Spectrum Disorders

Abstract

This proposal is aimed to further characterize this important pathway in the developing brain and to understand how it is involved in ASD. The specific objectives include: 1) Further analyze and characterize the complement pathway in the developing brain using mouse models; 2) Expand and validate ASD related variants in the complement pathway; 3) Focus on specific ASD related potentially deleterious variants, generate patient-derived induced pluripotent stem cells (iPSC) lines, and subject the iPSC-derived neural stem cells and neurons to functional studies in order to unravel how complement system dysregulation may be presented as ASD. This collaborative study is likely to shed light on the involvement of a cascade that acts in the periphery as an immune surveillance system in brain development and in ASD. This new approach will increase our understanding of the developmental events that lead to ASD and may lead to future development of therapeutic agents. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MANSUR, FERNANDA; TELES E SILVA, ANDRE LUIZ; SANTOS GOMES, ANA KAROLYNE; MAGDALON, JULIANA; DE SOUZA, JANAINA SENA; GRIESI-OLIVEIRA, KARINA; PASSOS-BUENO, MARIA RITA; SERTIE, ANDREA LAURATO. Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 14 JUL 2021. Web of Science Citations: 0.
MAGDALON, JULIANA; MANSUR, FERNANDA; TELES E SILVA, ANDRE LUIZ; DE GOES, VITOR ABREU; REINER, ORLY; SERTIE, ANDREA LAURATO. Complement System in Brain Architecture and Neurodevelopmental Disorders. FRONTIERS IN NEUROSCIENCE, v. 14, FEB 5 2020. Web of Science Citations: 0.
SANCHEZ-SANCHEZ, SANDRA M.; MAGDALON, JULIANA; GRIESI-OLIVEIRA, KARINA; YAMAMOTO, GUILHERME L.; SANTACRUZ-PEREZ, CAROLINA; FOGO, MARIANA; PASSOS-BUENO, MARIA RITA; SERTIE, ANDREA L. Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder. Human mutation, v. 39, n. 10, p. 1372-1383, OCT 2018. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.