Advanced search
Start date
Betweenand

Longitudinal multimodal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury

Abstract

Traumatic brain injury (TBI) is an important cause of morbidity and mortality, with serious economic and social consequences. Diffuse axonal injury (DAI) derives from rotational or shearing forces in brain parenchyma, and it is the pathological substrate in many patients who require hospital admission. The surviving patients may present serious functional and cognitive impairment, often with poor quality of life and psychiatric symptoms. Magnetic resonance imaging (MRI) may demonstrate brain abnormalities related to DAI, but the conventional images underestimate the extent and severity of the lesions. Diffusion tensor imaging (DTI) is an advanced MRI sequence that may provide particular qualitative and quantitative information about brain microstructure and connectivity in vivo, and is also useful in monitoring disease progression. The main purpose of the study is to longitudinally evaluate the integrity of brain parenchyma of patients with moderate to severe DAI by taking advantage of multiple analytical methods of DTI and their correlations with clinical data, quality of life and neuropsychological tests. This work may help to understand the pathophysiology and progression of DAI and foster the development of new therapies and recovery of the quality of life of the affected patients. Furthermore, this project will be of great value in promoting the use of analytical techniques of DTI in our scientific community, favoring its future application in other research projects for the study of diverse neurological diseases. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRASSI, DAPHINE CENTOLA; DA CONCEICAO, DAVID MACEDO; LEITE, CLAUDIA DA COSTA; ANDRADE, CELI SANTOS. Current contribution of diffusion tensor imaging in the evaluation of diffuse axonal injury. Arquivos de Neuro-Psiquiatria, v. 76, n. 3, p. 189-199, . (15/18136-1, 17/17065-9, 16/05547-6)
DAPHINE CENTOLA GRASSI; GRASIELA ROCHA BARROS DA SILVA; CELI SANTOS ANDRADE. Reply. Arquivos de Neuro-Psiquiatria, v. 76, n. 10, p. -, . (15/18136-1, 17/17065-9, 16/05547-6)
DAPHINE CENTOLA GRASSI; ANA LUIZA ZANINOTTO; FABRÍCIO STEWAN FELTRIN; FABÍOLA BEZERRA DE CARVALHO MACRUZ; MARIA CONCEPCIÓN GARCÍA OTADUY; CLAUDIA DA COSTA LEITE; VINICIUS MONTEIRO DE PAULA GUIRADO; WELLINGSON SILVA PAIVA; CELI SANTOS ANDRADE. Análise longitudinal do encéfalo por tensor de difusão em lesão axonal difusa. Arquivos de Neuro-Psiquiatria, v. 80, n. 3, p. 280-288, . (16/05547-6, 17/17065-9, 15/18136-1)
ZANINOTTO, ANA LUIZA; GRASSI, DAPHINE CENTOLA; DUARTE, DANTE; RODRIGUES, PRISCILA APARECIDA; CARDOSO, ELLISON; FELTRIN, FABRICIO STEWAN; DE PAULA GUIRADO, VINICIUS MONTEIRO; DE CARVALHO MACRUZ, FABIOLA BEZERRA; GARCIA OTADUY, MARIA CONCEPCION; LEITE, CLAUDIA DA COSTA; et al. TI-derived parameters differ between moderate and severe traumatic brain injury and its association with psychiatric score. NEUROLOGICAL SCIENCES, v. 43, n. 2, . (15/18136-1)
GRASSI, DAPHINE CENTOLA; BARROS DA SILVA, GRASIELA ROCHA; ANDRADE, CELI SANTOS. Diffuse axonal injury: diffusion tensor imaging and cognitive outcome Reply. Arquivos de Neuro-Psiquiatria, v. 76, n. 10, p. 726-727, . (15/18136-1, 16/05547-6, 17/17065-9)
GRASSI, DAPHINE CENTOLA; ZANINOTTO, ANA LUIZA; FELTRIN, FABRICIO STEWAN; MACRUZ, FABIOLA BEZERRA CARVALHO; OTADUY, MARIA CONCEPCION GARCIA; LEITE, CLAUDIA COSTA; GUIRADO, VINICIUS MONTEIRO PAULA; PAIVA, WELLINGSON SILVA; SANTOS ANDRADE, CELI. Dynamic changes in white matter following traumatic brain injury and how diffuse axonal injury relates to cognitive domain. BRAIN INJURY, v. 35, n. 3, . (17/17065-9, 16/05547-6, 15/18136-1)
GRASSI, DAPHINE CENTOLA; DA CONCEICAO, DAVID MACEDO; LEITE, CLAUDIA DA COSTA; ANDRADE, CELI SANTOS. Current contribution of diffusion tensor imaging in the evaluation of diffuse axonal injury. Arquivos de Neuro-Psiquiatria, v. 76, n. 3, p. 11-pg., . (17/17065-9, 15/18136-1, 16/05547-6)

Please report errors in scientific publications list using this form.