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Analysis of the nanoemulsions associated with photodynamic therapy in the treatment of breast cancer

Abstract

Cancer remains one of the main problems of global health. Treatment of breast cancer involves the use of complex therapeutic resources, with unsatisfactory aesthetic results that imply, consequently, the social and psychological impairment of the patient due to originated mutilation of the breast region. Nanotechnology in the last decade, has emerged as one of the most promising tools for the cancer treatment. The nanoemulsions have attractive features as biological stability, biocompatibility, reduced toxicity associated with therapy against cancer, increased therapy efficiency, can be administered by different routes and can incorporate a wide variety of drug molecules. Therefore, the project aims to develop drug delivery nanoemulsions associated with photodynamic therapy for the treatment of breast cancer and to test the effectiveness of these nanoemulsions in vitro by nanoemulsion intracellular uptake, phototoxicity and cytotoxicity, cell proliferation and apoptosis assays. The efficiency of these nanoparticles are also tested in vivo by anti-tumor efficiency, analysis of the vascular permeability and angiogenesis. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, P. M.; LOPES, T. Z.; TEDESCO, A. C.; RAHAL, P.; CALMON, M. F.. Effect of berberine associated with photodynamic therapy in cell lines. Photodiagnosis and Photodynamic Therapy, v. 32, . (13/50181-1, 15/16660-5)
DA SILVA, DARLAN BARBOSA; DA SILVA, CAROLINA LOUREIRO; DAVANZO, NATHALIA NOSSI; SOUZA, RODRIGO DA SILVA; CORREA, RODRIGO JOSE; TEDESCO, ANTONIO CLAUDIO; RIEMMA PIERRE, MARIA BERNADETE. Protoporphyrin IX (PpIX) loaded PLGA nanoparticles for topical Photodynamic Therapy of melanoma cells. Photodiagnosis and Photodynamic Therapy, v. 35, . (13/50181-1, 15/16660-5)
GALIARDI-CAMPOY, ANA EMILIA BRUMATTI; MACHADO, FRANCIELLY CRISTINA; CARVALHO, TAMARA; TEDESCO, ANTONIO CLAUDIO; RAHAL, PAULA; CALMON, MARILIA FREITAS. Effects of photodynamic therapy mediated by emodin in cervical carcinoma cells. Photodiagnosis and Photodynamic Therapy, v. 35, . (13/50181-1, 15/16660-5)
FLORIANO, BARBARA FREITAS; CARVALHO, TAMARA; LOPES, TAIRINE ZARA; UNTEN TAKAHASHI, LUANDRA APARECIDA; RAHAL, PAULA; TEDESCO, ANTONIO CLAUDIO; CALMON, MARILIA FREITAS. Effect of berberine nanoemulsion Photodynamic therapy on cervical carcinoma cell line. Photodiagnosis and Photodynamic Therapy, v. 33, . (15/16660-5, 13/50181-1)
MACHADO, FRANCIELLY CRISTINA; BITTAR, CINTIA; RAHAL, PAULA; CALMON, MARILIA FREITAS. Identification of differentially expressed miRNAs in human cells infected with different Zika virus strains. ARCHIVES OF VIROLOGY, v. 166, n. 6, . (17/09197-2, 14/22198-0, 15/16660-5)
CANDIDO, NATALIA MARIA; DE MELO, MARYANNE TRAFANI; FRANCHI, LEONARDO PEREIRA; PRIMO, FERNANDO LUCAS; TEDESCO, ANTONIO CLAUDIO; RAHAL, PAULA; CALMON, MARILIA FREITAS. Combining Photodynamic Therapy and Chemotherapy: Improving Breast Cancer Treatment with Nanotechnology. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 14, n. 5, p. 994-1008, . (15/16660-5)
LOPES, TAIRINE ZARA; DE MORAES, FABIO ROGERIO; TEDESCO, ANTONIO CLAUDIO; ARNI, RAGHUVIR KRISHNASWAMY; RAHAL, PAULA; CALMON, MARILIA FREITAS. Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells (vol 123, 109794, 2020). BIOMEDICINE & PHARMACOTHERAPY, v. 125, p. 1-pg., . (14/22198-0, 15/13765-0, 15/16660-5)

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