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NANOCEL - development of enzyme mixtures for the preparation of nanocelluloses by a biohibrid process


Nanocellulose is a new class of renewable nanomaterial that can lead to several benefits in areas such as biomedical, automotive, aerospace, pharmaceuticals, chemicals, and electronics. The traditional production processes involves severe chemical or mechanical treatment steps, which have several technical, economic and environmental limitations. The recent proposal to add or replace one of these steps by an enzymatic treatment is an innovative and promising alternative, but still with very limited efficiency since the enzyme preparations typically used are developed and optimized for use in other industrial sectors (i.e. food, textile, pulp and paper). Therefore, to increase the efficiency of the enzymatic treatment, auxiliary pre-treatment steps are necessary for production of cellulose nanofibrillated (CNF), and a high amount of enzyme is necessary in the production of cellulose nanocrystalline (CNC), which all results in high cost. In this project it is proposed to identify essential enzymes and proteins and their properties more suitable for application in the production of nanocelluloses and using these enzymes and proteins to develop and optimize specific enzymatic preparations with high efficiency to be used in the production of CNC and CNF in a sustainably and more technoeconomically feasible manner. The identification of these biochemical agents and their properties will be obtained through the elucidation of the mode of action and interaction of various biochemical systems (hydrolytic, oxidative, amorphogenesis-inducing) in the production of CNC and CNF. A novel adsorption-based enzymatic reaction system will be developed to enable the production of nanocellulose in a Biorefinery concept. The development of enzymatic preparations and adsorptive enzymatic reaction process will also allow assessing the techno-economic feasibility of integrating the production of nanocelluloses (as a high value co-product) with the cellulosic ethanol production process in a Biorefinery concept. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSALES-CALDERON, OSCAR; PEREIRA, BARBARA; ARANTES, VALDEIR. Economic assessment of the conversion of bleached eucalyptus Kraft pulp into cellulose nanocrystals in a stand-alone facility via acid and enzymatic hydrolysis. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. 15, n. 6, . (15/02862-5)
MAROTTI, BRAZ DE SOUZA; ARANTES, VALDEIR. ltra-refining for the production of long-term highly pH-stable lignin nanoparticles in high yield with high uniformit. GREEN CHEMISTRY, v. 24, n. 3, p. 1238-1258, . (15/02862-5)
BERTO, GABRIELA L.; MATTOS, BRUNO D.; ROJAS, ORLANDO J.; ARANTES, VALDEIR. Single-Step Fiber Pretreatment with Monocomponent Endoglucanase: Defibrillation Energy and Cellulose Nanofibril Quality. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 9, n. 5, p. 2260-2270, . (15/02862-5)
MARCONDES, WILIAN F.; MILAGRES, ADRIANE M. F.; ARANTES, VALDEIR. Co-production of xylo-oligosaccharides, xylose and cellulose nanofibrils from sugarcane bagasse. Journal of Biotechnology, v. 321, p. 35-47, . (15/02862-5)
BERTO, GABRIELA L.; ARANTES, VALDEIR. Kinetic changes in cellulose properties during defibrillation into microfibrillated cellulose and cellulose nanofibrils by ultra-refining. International Journal of Biological Macromolecules, v. 127, p. 637-648, . (15/02862-5)
SIQUEIRA, GERMANO A.; DIAS, ISABELLA K. R.; ARANTES, VALDEIR. Exploring the action of endoglucanases on bleached eucalyptus kraft pulp as potential catalyst for isolation of cellulose nanocrystals. International Journal of Biological Macromolecules, v. 133, p. 1249-1259, . (15/02862-5, 15/00397-3)
PEREIRA, BARBARA; MARCONDES, WILIAN F.; CARVALHO, WALTER; ARANTES, VALDEIR. High yield biorefinery products from sugarcane bagasse: Prebiotic xylooligosaccharides, cellulosic ethanol, cellulose nanofibrils and lignin nanoparticles. Bioresource Technology, v. 342, . (15/02862-5)
COELHO DE CARVALHO BENINI, KELLY CRISTINA; CORNELIS VOORWALD, HERMAN JACOBUS; HILARIO CIOFFI, MARIA ODILA; REZENDE, MIRABEL CERQUEIRA; ARANTES, VALDEIR. Preparation of nanocellulose from Imperata brasiliensis grass using Taguchi method. Carbohydrate Polymers, v. 192, p. 337-346, . (11/14153-8, 15/02862-5)
ARANTES, VALDEIR; DIAS, ISABELLA K. R.; BERTO, GABRIELA L.; PEREIRA, BARBARA; MAROTTI, BRAZ S.; NOGUEIRA, CARLAILE F. O.. The current status of the enzyme-mediated isolation and functionalization of nanocelluloses: production, properties, techno-economics, and opportunities. Cellulose, v. 27, n. 18, SI, . (15/02862-5)

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Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180684850 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - September 2018, 12

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180747843 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - November 2018, 29