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Myocardial proteome of obese rats by Western diet with cardiac dysfunction

Grant number: 15/16934-8
Support Opportunities:Regular Research Grants
Duration: November 01, 2015 - April 30, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Antonio Carlos Cicogna
Grantee:Antonio Carlos Cicogna
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated researchers:Katashi Okoshi ; Lucilene Delazari dos Santos

Abstract

Obesity is a chronic metabolic disease characterized by abnormal or excessive accumulation of fat in relation to lean tissue mass. It is considered a global epidemic caused by multiple factors, being primarily responsible for this pathology sedentary lifestyle combined with excessive food intake. Comorbidities such as, cancer, insulin resistance, type 2 diabetes mellitus, dyslipidemia and cardiovascular diseases are strongly associated with obesity. Studies involving obese humans would be useful in understanding the mechanisms involved in cardiac dysfunction, however, is very difficult to obtain adequate samples, due to various limitations. Therefore, the use of animal models has been increasingly steady in the investigation of the deleterious effects of excess adipose tissue in the heart. This relationship has been examined in obese animals by genetic or dietary manipulations, which latter stands out for being more realistic and more appropriately represent the phenotypic variety of the obese patient. The hyperlipidemic diets are the alternatives used by most research groups to study heart disease due to obesity, however, the results regarding the impact of these diets on the structure and function of the heart are conflicting. Thus, the use of high-fat diet has been questioned, and suggested the use of a diet rich in fats and simple carbohydrates, known as "Western", which can more accurately reproduce the contemporary consumer responsible for the obesity epidemic. The mechanisms related to committal cardiovascular in obesity are not fully elucidated, and studies in this direction is a trend in healthcare. Therewith, one of the research approaches that have been highlighted in the last decade is the proteomic analysis, whose function is to describe the entire set of proteins expressed in a genome under specific conditions and at a given time point, from a cell, tissue or body. Cardiovascular proteomic is one of the most studied areas in the field of proteomic health, however, in models of obesity by diet, it has been little explored, not being found studies that associated cardiac function. Therefore, the aim of this project is to identify myocardial proteins of obese rats by "Western" diet with cardiac dysfunction, using proteomic analysis. With this proposal, we can see which are the proteins that are expressed differently in the myocardium of obese rats with cardiac dysfunction compared to healthy rats, to understand the network of mechanisms involved in heart disease. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, VITOR LOUREIRO; MOTA, GUSTAVO AUGUSTO FERREIRA; DE SOUZA, SERGIO LUIZ BORGES; DE CAMPOS, DIJON HENRIQUE SALOME; MELO, ALEXANDRE BARROSO; VILEIGAS, DANIELLE FERNANDES; COELHO, PRISCILA MURUCCI; SANT'ANA, PAULA GRIPPA; PADOVANI, CARLOS; LIMA-LEOPOLDO, ANA PAULA; et al. Aerobic Exercise Training Improves Calcium Handling and Cardiac Function in Rats with Heart Failure Resulting from Aortic Stenosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 15, p. 20-pg., . (15/20013-5, 15/16934-8)
VILEIGAS, DANIELLE FERNANDES; DE SOUZA, SERGIO LUIZ BORGES; CORREA, CAMILA RENATA; SILVA, CAROL CRISTINA VAGULA DE ALMEIDA; DE CAMPOS, DIJON HENRIQUE SALOME; PADOVANI, CARLOS ROBERTO; CICOGNA, ANTONIO CARLOS. The effects of two types of Western diet on the induction of metabolic syndrome and cardiac remodeling in obese rats. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 92, . (14/22152-0, 15/16934-8)
VILEIGAS, DANIELLE FERNANDES; DE CARVALHO MARCIANO, CECILIA LUME; FERREIRA MOTA, GUSTAVO AUGUSTO; BORGES DE SOUZA, SERGIO LUIZ; SANT'ANA, PAULA GRIPPA; OKOSHI, KATASHI; PADOVANI, CARLOS ROBERTO; CICOGNA, ANTONIO CARLOS. Temporal Measures in Cardiac Structure and Function During the Development of Obesity Induced by Different Types of Western Diet in a Rat Model. NUTRIENTS, v. 12, n. 1, . (15/10782-1, 14/22152-0, 15/16934-8)
SANT'ANA, PAULA GRIPPA; DE TOMASI, LORETA CASQUEL; MURATA, GILSON MASAHIRO; VILEIGAS, DANIELLE FERNANDES; MOTA, GUSTAVO AUGUSTO FERREIRA; DE SOUZA, SERGIO LUIZ BORGES; SILVA, VITOR LOUREIRO; DE CAMPOS, LIVIA PASCHOALINO; OKOSHI, KATASHI; PADOVANI, CARLOS ROBERTO; et al. Hypoxia-Inducible Factor 1-Alpha and Glucose Metabolism during Cardiac Remodeling Progression from Hypertrophy to Heart Failure. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 7, p. 18-pg., . (15/16934-8)
VILEIGAS, DANIELLE F.; HARMAN, VICTORIA M.; FREIRE, PAULA P.; MARCIANO, CECILIA L. C.; SANT'ANA, PAULA G.; DE SOUZA, SERGIO L. B.; MOTA, GUSTAVO A. F.; DA SILVA, VITOR L.; CAMPOS, DIJON H. S.; PADOVANI, CARLOS R.; et al. Landscape of heart proteome changes in a diet-induced obesity model. SCIENTIFIC REPORTS, v. 9, . (17/09688-6, 15/16934-8, 14/22152-0)

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