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Development of functionalized calcium phosphate nanoparticles for use in resin-based dental composites

Grant number: 15/15019-4
Support Opportunities:Regular Research Grants
Duration: November 01, 2015 - October 31, 2017
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Roberto Ruggiero Braga
Grantee:Roberto Ruggiero Braga
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers: Carmem Silvia Costa Pfeifer ; Marcela Charantola Rodrigues
Associated grant(s):16/50321-6 - Development of calcium phosphate nanoparticles functionalized with acidic monomers for dental remineralization, AP.R SPRINT


In this project, the synthesis of calcium orthophosphate nanoparticles functionalized with ethylene glycol dimethacrylate derivatives (EGDMA, DEGDMA, TEGDMA and TETDMA) will be investigated with the purpose of obtaining particles with low agglomeration and chemical interaction with dimethacrylate-based resin matrices. The ultimate goal is the development of resin composites associating mechanical properties compatible with their potential clinical applications and bioactivity (through calcium and phosphate ion release). The project is divided in three phases. In phase 1, functionalized dicalcium phosphate dihydrate (DCPD) powders will be synthesized and characterized regarding the presence of the functionalized agent, surface area, size and morphology. In the second phase, the powders displaying the desirable characteristics in terms of size and functionalization will be incorporated in a resin matrix and the resulting materials will be tested for mechanical properties, ion release and microstructure. Finally, in phase 3, the powders showing the best behavior in the previous phase will be tested in formulations including silanated Barium glass particles, and evaluated according to the same methods used in phase 2. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NATALE, LIVIA C.; RODRIGUES, MARCELA C.; ALANIA, YVETTE; CHIARI, MARINA D. S.; VILELA, HANDIALLY S.; VIEIRA, DOUGLAS N.; ARANA-CHAVEZ, VICTOR; MEIER, MARCIA M.; VICHI, FLAVIO M.; BRAGA, ROBERTO R.. Development of calcium phosphate/ethylene glycol dimethacrylate particles for dental applications. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 107, n. 3, p. 708-715, . (15/15019-4)
NATALE, LIVIA C.; RODRIGUES, MARCELA C.; ALANIA, YVETTE; CHIARI, MARINA D. S.; BOARO, LETICIA C. C.; COTRIM, MARYCEL; VEGA, OSCAR; BRAGA, ROBERTO R.. Mechanical characterization and ion release of bioactive dental composites containing calcium phosphate particles. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 84, p. 161-167, . (15/15019-4)

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