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Prevalence and incidence of early central nervous system disturbance in HTLV-1-infected subjects in Brazil


There are approximately 20 million people infected with HTLV-1 worldwide, and Brazil has approximately 1 million of persons living with HTLV-1 infection (PLHTLV). Despite few patients (<5%) will develop classical syndromes (ATLL and HAM/TSP) life long, preliminary observations indicate that other symptoms, including xerosis, sicca and may develop. However, minor neurological disturbances which have been not studied may cause impact over the patients. These non-characterized symptoms may pass undercover and have impact on quality of life in these HTLV-1-infected subjects. In this regard, the Project aims at understanding the basic mechanisms of HTLV-1 to identify risk factors for minor neurological disturbances. The results of such studies are expected to produce gains in the development of new inputs, as well as serve as biomarkers of progression, the control of these diseases and impact on quality of life. Fundamentally, this proposal will support the Nucleus of Research Support (NAP)-Retrovirus-USP which has as main purpose to integrate several lines of research and organizing processes that can result in improvements in the health care of people infected by retroviruses, such as HTLV-1 infection. Moreover, the Project aims to empower staff in improving technologies for research and care of patients with retroviruses, especially HTLV-1-infected subjects with minor symptoms, probably neglected during the regular primary care. Finally, the integration of different expertise in different areas contributed to the scientific and technological development in the country, which may allow a significant improvement in clinical care, diagnosis and treatment of people living with HTLV-1, especially those with minor neurological disturbances. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FUTSCH, NICOLAS; PRATES, GABRIELA; MAHIEUX, RENAUD; CASSEB, JORGE; DUTARTRE, HELENE. Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases. Viruses-Basel, v. 10, n. 12, . (14/22827-7)
PAIVA, ARTHUR M.; ASSONE, TATIANE; HAZIOT, MICHEL E. J.; SMID, JERUSA; FONSECA, LUIZ AUGUSTO M.; LUIZ, OLINDA DO CARMO; PENALVA DE OLIVEIRA, AUGUSTO CESAR; CASSEB, JORGE. Risk factors associated with HTLV-1 vertical transmission in Brazil: longer breastfeeding, higher maternal proviral load and previous HTLV-l-infected offspring. SCIENTIFIC REPORTS, v. 8, . (14/22827-7, 16/03025-2)
JORGE CASSEB; ANA PAULA R. VEIGA; MARCELLO M. C. MAGRI; MARIANA A. MONTEIRO; ROSANA C. ROCHA; MARIA RITA P. GASCON; MAURICIO DOMINGUES-FERREIRA; THALES J. B. POLIS; NAJARA A. DE LIMA NASCIMENTO; ISADORA LIMONGELLI; et al. Fighting HIV/AIDS in a developing country: lessons from a small cohort from the largest Brazilian city. Revista do Instituto de Medicina Tropical de São Paulo, v. 62, p. -, . (14/22827-7)
ASSONE, TATIANE; MALTA, FERNANDA M.; BAKKOUR, SONIA; MONTALVO, LEILANI; PAIVA, ARTHUR M.; SMID, JERUSA; PENALVA DE OLIVEIRA, AUGUSTO CESAR; GONCALVES, FERNANDA DE TOLEDO; LUIZ, OLINDA DO CARMO; FONSECA, LUIZ AUGUSTO M.; et al. Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects. VIRUS RESEARCH, v. 244, n. SI, p. 71-74, . (14/22827-7, 12/23397-0)
ASSONE, TATIANE; PAIVA, ARTHUR; FONSECA, LUIZ AUGUSTO M.; CASSEB, JORGE. Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections. Viruses-Basel, v. 8, n. 2, . (12/23397-0, 14/22827-7)
ASSONE, TATIANE; KANASHIRO, TATIANA M.; BALDASSIN, MAIRA P. M.; PAIVA, ARTHUR; HAZIOT, MICHEL E.; SMID, JERUSA; DE OLIVEIRA, AUGUSTO PENALVA; FONSECA, LUIZ AUGUSTO M.; NORRIS, PHILIP J.; CASSEB, JORGE. In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1. Brazilian Journal of Infectious Diseases, v. 22, n. 2, p. 106-112, . (12/23397-0, 14/22827-7)
DAHY, FLAVIA ESPER; PALHARES, RENATA BASIC; ASSONE, TATIANE; SMID, JERUSA; LUISI DE MOURA, JOAO VICTOR; HAZIOT, MICHEL E. J.; MARCUSSO, ROSA MARIA N.; PENALVA DE OLIVEIRA, AUGUSTO CESAR; CASSEB, JORGE. mall cells lung epidermoid carcinoma in a HTLV1-infected patient: case report and literature revie. Revista do Instituto de Medicina Tropical de São Paulo, v. 63, . (14/22827-7)

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