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Evaluation of activated isogenic dendritic cells and imiquimod as therapeutic alternative in sporotrichosis on immunosuppressed and immunocompetent animals

Grant number: 15/04023-0
Support type:Regular Research Grants
Duration: November 01, 2015 - October 31, 2017
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Iracilda Zeppone Carlos
Grantee:Iracilda Zeppone Carlos
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Sporotrichosis is an important mycosis with worldwide distribution that affects humans and animals. The infection is usually caused by traumatic inoculation of the fungus Sporothrix schenckii complex (composed of: S. brasiliensis, S. globosa, S mexicana and S. schenckii luriei strict sense) and clinical manifestations can range from skin infection, lymphocutaneous and systemic infection, most commonly seen in immunocompromised patients. Many cases of sporotrichosis caused by scratches from cats and by contact with contaminated wounds were reported in several cities in Brazil, mainly in Rio de Janeiro city, where the disease reached epidemic proportions and now in the state of São Paulo there are increasing reports of the incidence of disease, and is currently a major concern for health authorities. Current therapeutic tools against sporotrichosis require long periods of treatment and are associated with frequent adverse effects, sometimes severe. Therefore, there is a great need to develop more effective and safe methods for antifungal therapy, especially in immunocompromised patients. Many studies have been conducted showing the use of activated dendritic cells for the development of therapy against several disease, including tumors and chronic infections. However, studies related to this methodology in fungal infections, especially in sporotrichosis, are still scarce. The Imiquimod is an immunostimulatory compound that has been shown to be effective in the therapy against tumors and chronic infections of the skin. Moreover, it has shown microbicidal activity including antifungal, but there are no studies done to evaluate its therapeutic effect in sporotrichosis. Thus, the objective of this study is to evaluate the therapeutic capacity of isogenic activated dendritic cells and imiquimod in model of infection with S. schenckii in immunocompromised and immunocompetent mice. These data will be used in the future to generate alternative therapeutic tools against sporotrichosis. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, LUCAS SOUZA; PORTUONDO, DEIVYS LEANDRO; POLESI, MARISA CAMPOS; CARLOS, IRACILDA ZEPPONE. Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii. IMMUNOLOGY, v. 155, n. 4, p. 467-476, DEC 2018. Web of Science Citations: 1.
QUINELLO, CAMILA; FERREIRA, LUCAS SOUZA; PICOLLI, ISABELLA; LOESCH, MARIA LUIZA; PORTUONDO, DEIVYS LEANDRO; BATISTA-DUHARTE, ALEXANDER; CARLOS, IRACILDA ZEPPONE. Sporothrix schenckii CellWall Proteins-Stimulated BMDCs Are Able to Induce a Th1-Prone Cytokine Profile In Vitro. JOURNAL OF FUNGI, v. 4, n. 3 SEP 2018. Web of Science Citations: 3.
MANENTE, FRANCINE ALESSANDRA; QUINELLO, CAMILA; FERREIRA, LUCAS SOUZA; DE ANDRADE, CLEVERTON ROBERTO; JELLMAYER, JULIANA APARECIDA; PORTUONDO, DEIVYS LEANDRO; BATISTA-DUHARTE, ALEXANDER; CARLOS, IRACILDA ZEPPONE. Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model. Medical Mycology, v. 56, n. 6, p. 711-722, AUG 2018. Web of Science Citations: 5.
GONCALVES, AMANDA COSTA; FERREIRA, LUCAS SOUZA; MANENTE, FRANCINE ALESSANDRA; QUINELLO GOMES DE FARIA, CAROLINA MARIA; POLESI, MARISA CAMPOS; DE ANDRADE, CLEVERTON ROBERTO; ZAMBONI, DARIO SIMOES; CARLOS, IRACILDA ZEPPONE. The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection. IMMUNOLOGY, v. 151, n. 2, p. 154-166, JUN 2017. Web of Science Citations: 17.

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