Research Grants 14/15720-1 - Oftalmologia, Transplante de medula óssea - BV FAPESP
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Characterization of tear film inflammatory mediators and of cytologic profile from the ocular surface of patients presenting graft-versus-host-disease

Abstract

Graft versus host disease (GVHD) is a complication of bone marrow transplantation. Around 45-60% of transplanted patients develop ocular manifestations, and dry eye is the most frequent one. The severity can be related to manifest GVHD and meibomian glands dysfunction, which can disturb patient's quality of life. Reports demonstrating that keratoconjunctivitis sicca is an immunological consequence of GVHD are rare. This prospective diagnostic interventional study with minimal risk for subjects aims to analyze the immunological tear profile in those patients as well as to characterize the histological features on their ocular surface. Patients (n=50) will be evaluated by the Bone Marrow Transplantation Sector of the Hematology Department and by the Ophthalmology Department, both from Federal University of São Paulo (UNIFESP) pre-operatively and at 30, 60, 90, 150, 180, and 360 post-operative days, or at any other post-operative time the disease manifests. Inclusion criteria consist of 50 patients who present hematological diseases requiring bone marrow transplantation. Parameters to be analyzed: complete ophthalmologic exam, tear film rupture time, Schirmer's test, 1% Fluorescein test, 1% Rose Bengal test, impression cytology, and tear analysis. Patients will complete the "Ocular Surface Disease Index" (OSDI) questionnaire to determine their subjective symptoms and quality of life. Patients who refuse to spontaneously sign the consent form for the ophthalmologic evaluation will be excluded. The results from this study can clarify the physiopathology of keratoconjunctivitis sicca and allow for tailored and specific therapy with anti-inflammatory drugs instead of artificial tears and surgical procedures such as punctal occlusion and tarsorraphy. The same methodology could be applied for a better understanding of other inflammatory process affecting the ocular surface (immune disease, trauma as chemical burns, and immunologic rejection of corneal grafts) and so far allow for a novel and tailored therapy. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SERAPICOS, PATRICIA; KIM, CINTHIA; BARROS, SABRINA LEITE; MENDES SILVA JORDAO, ISA MARIA BASTOS; HIYANE, MEIRE IOSHIE; DE SOUSA, LUCIENE BARBOSA; ZECCHIN, VICTOR GOTTARDELLO; SARAIVA CAMARA, NIELS OLSEN; DE OLIVEIRA, LAURO AUGUSTO. Tear Film Immunological Profile in Patients with Ocular Graft versus Host Disease. OCULAR IMMUNOLOGY AND INFLAMMATION, v. N/A, p. 9-pg., . (14/15720-1)
MOURA, GUSTAVO SOUZA; SANTOS, ALBERT; CENEDEZE, MARCOS ANTONIO; HIYANE, MEIRE IOSHIE; SARAIVA CAMARA, NIELS OLSEN; DE SOUSA, LUCIENE BARBOSA; DE OLIVEIRA, LAURO AUGUSTO. Increased lacrimal inflammatory mediators in patients with keratoconus. MOLECULAR VISION, v. 27, p. 656-665, . (14/15720-1)

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