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Effects of inflammatory nociceptive stimulation in newborn rats: behavioral and neurobiological changes and behavioral consequences in adulthood

Grant number: 15/09888-0
Support Opportunities:Regular Research Grants
Duration: September 01, 2015 - August 31, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Luciene Covolan
Grantee:Luciene Covolan
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers: Antônio Carlos Guimarães de Almeida ; Deborah Suchecki ; Ricardo Borges Machado


Invasive painful procedures are often performed in neonates admitted into intensive care units (ICU). The acute and long-term stimulation caused by these procedures can be investigated in animal models, such as newborn rats. Previous studies have shown that animals subjected to noxious stimulation in the neonatal period have behavioral changes, such as signs of anxiety or depression. Under the same conditions, neonatal stimuli also lead to increase in neurogenesis rate and cellular activation in the hippocampus. Thus, it is of great interest to investigate whether such cellular alterations can be correlated to the behavioral changes. It is also true that stressful events in adulthood can bring out behavioral manifestations that once were in latent state; and stressful events in critical periods of development can undermine the resilience mechanisms to stress. In this scenario, the study proposal has been designed over three lines investigation from the neonatal nociceptive stimulation (induced in the first or eighth day after birth, with the intraplantar injection of CFA Freund's adjuvant -complete): I - behavioral parameters indicative of like-anxious and depressive-like behaviors after the challenge (movement restriction stress); II - analysis of sleep parameters (macro and micro-architecture) at baseline conditions, post-stress and after the sleep deprivation (homeostatic response); III - cellular mechanisms involved, such electrophysiological analysis of the hippocampus (LTP), central monoamines, receptors expression (5-HT1A) and signaling factors (p-CREB) in key structures involved in the emotional behavior regulation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MALHEIROS, JACKELINE M.; ANDREETA, MARIANE B.; POLLI, ROBERSON S.; PAIVA, FERNANDO F.; TANNUS, ALBERTO; GUINSBURG, RUTH; COVOLAN, LUCIENE. Adult brain activation in response to pain is changed by neonatal painful stimulation according to sex: A manganese-enhanced MRI study. European Journal of Neuroscience, v. 53, n. 2, . (15/09888-0, 05/56663-1)

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