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Multi-User Equipment, previously approved in grant 2015/08166-5: stopped-flow

Grant number: 15/10411-3
Support type:Multi-user Equipment Program
Duration: September 01, 2015 - August 31, 2017
Field of knowledge:Biological Sciences - Biophysics - Molecular Biophysics
Principal researcher:Iolanda Midea Cuccovia
Grantee:Iolanda Midea Cuccovia
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/08166-5 - Interfacial chemistry: drugs, peptides and ezymes interactions with membrane models, AP.TEM
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Type of equipment:Processos Físicos - Manipulação de amostras - Fluxo interrompido (stopped flow)
Caracterização de Materiais - Espectroscopia - Óptica (UV-Visível)
Manufacturer: Fabricante não informado
Model: Modelo não informado

Abstract

Using micelles and vesicles as models we will focus questions representing new frontiers in the study of interfacial properties using methods we have used for decades and deploying new techniques in collaboration with researchers from Brazil and abroad. Can we design (synthesize) self-aggregating surfactants that form vesicles capable of catalyzing and self-replicate? What is the role of lipid bilayer asymmetry in the properties and selective adsorption of ions or on the electrostatic properties of membranes? How can this selective binding of ions influence membrane / peptide interactions? How are ions are distributed within vesicles? What is the mechanism of association of the triflate ion in micelles and what does this tell us about ion association to interfaces? Using the dediazoniation reaction of substituted diazobenzenes can we design a nucleophilicity scale relevant to biological systems and determine ideality in solvent mixtures? How do mixed polymers aggregate and catalyze? How does human paraoxonase and asparaginase behave when interacting with membranes? What is the mechanism of interaction of BP100, a semisynthetic undecapeptide, with membranes? Can new imidazole derivatives and anti-inflammatory compounds be efficiently incorporated in liposomes? The answers to these questions, which are part of a line of thought of our group, will bring fundamental and applied contributions in the area of biomimetic systems. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PESKIN, V, ALEXANDER; MEOTTI, FLAVIA C.; KEAN, KELSEY M.; GOBL, CHRISTOPH; PEIXOTO, ALBERT SOUZA; PACE, PAUL E.; HORNE, CHRISTOPHER R.; HEATH, SARAH G.; CROWTHER, JENNIFER M.; DOBSON, RENWICK C. J.; et al. Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2. Journal of Biological Chemistry, v. 296, . (13/07937-8, 15/10411-3, 18/14898-2)
LACERDA, CAROLINE DUTRA; CALEGARI ANDRADE, MARCOS FELIPE; PESSOA, PHILLIPE DE SANTANA; PRADO, FERNANDA MANSO; RODRIGUES PIRES, PAULO AUGUSTO; PINATTO-BOTELHO, MARCOS FELIPE; WODTKE, FELIPE; DOS SANTOS, ALCINDO APARECIDO; DIAS, LUIS GUSTAVO; LIMA, FILIPE DA SILVA; et al. Experimental mapping of a pH gradient from a positively charged micellar interface to bulk solution. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 611, . (15/10411-3, 14/50983-3, 13/08166-5)
CARRETERO, GUSTAVO PENTEADO BATTESINI; SARAIVA, GREICE KELLE VIEGAS; RODRIGUES, MAGALI APARECIDA; KIYOTA, SUMIKA; BEMQUERER, MARCELO PORTO; CHAIMOVICH, HERNAN; CUCCOVIA, IOLANDA MIDEA. Naphthalimide-Containing BP100 Leads to Higher Model Membranes Interactions and Antimicrobial Activity. BIOMOLECULES, v. 11, n. 4, . (18/15230-5, 14/50983-3, 13/08166-5, 15/10411-3)
ROCHA, LEONARDO SILVA; DA SILVA, BEATRIZ PEREIRA; CORREIA, THIAGO M. L.; DA SILVA, RAILMARA PEREIRA; MEIRELES, DIOGO DE ABREU; PEREIRA, RAFAEL; SOARES NETTO, LUIS EDUARDO; MEOTTI, FLAVIA CARLA; QUEIROZ, RAPHAEL FERREIRA. Peroxiredoxin AhpC1 protects Pseudomonas aeruginosa against the inflammatory oxidative burst and confers virulence. REDOX BIOLOGY, v. 46, . (15/21563-9, 13/07937-8, 15/10411-3, 18/14898-2, 19/26473-9)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.