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Effects of exposure to ambient/occupational pollution on idiopathic pulmonary fibrosis

Grant number: 15/00830-9
Support Opportunities:Regular Research Grants
Duration: July 01, 2015 - June 30, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Adriana Lino dos Santos Franco
Grantee:Adriana Lino dos Santos Franco
Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Associated researchers:Ana Paula Ligeiro de Oliveira ; Rodolfo de Paula Vieira ; Wothan Tavares de Lima

Abstract

The ambient/occupational pollution has been object of study for many researchers due its serious implications on the public health. The Formaldehyde (FA) is a chemical agent widely used a lot of industries, laboratories of anatomy, pathology, histology, emitted for the fuel burning, and also it is expelled in the smoke of the cigarette, which is characterized by ambient and occupational pollutant. The FA is an irritating of the airways, inductor of lung inflammation and a carcinogenic agent. The literature has shown the correlation between exposure to pollution and development or worsening of lung diseases. In this context, our scientific studies have addressed the harmful action of exposure to FA on lung tissue. Among the lung diseases, idiopathic pulmonary fibrosis (IPF) is a serious disease with a progressive and chronic condition whose etiology is unknown and the incidence is high resulting in considerable morbidity and mortality. Initial studies show worsening of patients with IPF when exposed to pollutants such as ozone and nitrogen dioxide, suggesting that pollution may contribute to the worsening this disease. Thus, the impact of pollution on the course of IPF is not well elucidated thus needing to be investigated. Based on this observation and on our research topic, the association of exposure to FA and its consequences for the worsening of the IPF will be the subject of study of this project. Our studies will prioritize the analysis of cells present into the lung, release and gene expression of inflammatory and anti-inflammatory cytokines, evaluation of lung function, airway remodeling and structural cells in culture. This project was conceived considering that the inquiry of the molecular mechanisms of the effect caused for the ambient and occupational poisoning is, today, a fact essential to explain the data unquestioned epidemiologists of the actual damages for the pollution to the health human being and also will contribute with the elucidation of FPI pathogenesis. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOSO SIQUEIRA, VANESSA PEROSINO; SILVEIRA EVANGELISTA, MARINA IZADORA; DOS SANTOS, ALANA; MARCOS, RODRIGO LABAT; LIGEIRO-DE-OLIVEIRA, ANA PAULA; PAVANI, CHRISTIANE; DAMAZO, AMILCAR SABINO; LINO-DOS-SANTOS-FRANCO, ADRIANA. Light-Emitting Diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin. Journal of Biophotonics, v. 10, n. 12, p. 11-pg., . (15/08041-3, 15/00830-9)
MACEDO, RODRIGO SILVA; LEAL, MAYARA PERES; BRAGA, TARCIO TEODORO; BARIONI, ERIC DIEGO; DURO, STEPHANIE DE OLIVEIRA; RATTO TEMPESTINI HORLIANA, ANNA CAROLINA; SARAIVA CAMARA, NIELS OLSEN; MARCOURAKIS, TANIA; POLISELLI FARSKY, SANDRA HELENA; LINO-DOS-SANTOS-FRANCO, ADRIANA. Photobiomodulation Therapy Decreases Oxidative Stress in the Lung Tissue after Formaldehyde Exposure: Role of Oxidant/Antioxidant Enzymes. Mediators of Inflammation, v. 2016, p. 9-pg., . (15/00830-9)
DA SILVA, CRISTIANE MIRANDA; LEAL, MAYARA PERES; BROCHETTI, ROBSON ALEXANDRE; BRAGA, TARCIO; VITORETTI, LUANA BEATRIZ; SARAIVA CAMARA, NIELS OLSEN; DAMAZO, AMILCAR SABINO; LIGEIRO-DE-OLIVEIRA, ANA PAULA; CHAVANTES, MARIA CRISTINA; LINO-DOS-SANTOS-FRANCO, ADRIANA. Low Level Laser Therapy Reduces the Development of Lung Inflammation Induced by Formaldehyde Exposure. PLoS One, v. 10, n. 11, . (11/51711-9, 12/16498-5, 15/00830-9)
CANDEO, LARISSA CARBONERA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRITO, AURILEIA APARECIDA; MARCOS, RODRIGO LABAT; FRANCA, CRISTIANE MIRANDA; SANTOS FERNANDES, KRISTIANNE PORTA; MESQUITA-FERRARI, RAQUEL AGNELLI; BUSSADORI, SANDRA KALIL; VIEIRA, RODOLFO PAULA; LINO-DOS-SANTOS-FRANCO, ADRIANA; et al. Effects of periodontitis on the development of asthma: The role of photodynamic therapy. PLoS One, v. 12, n. 11, . (15/20535-1, 12/16498-5, 15/23152-6, 15/00830-9)
CARDOSO SIQUEIRA, VANESSA PEROSINO; SILVEIRA EVANGELISTA, MARINA IZADORA; DOS SANTOS, ALANA; MARCOS, RODRIGO LABAT; LIGEIRO-DE-OLIVEIRA, ANA PAULA; PAVANI, CHRISTIANE; DAMAZO, AMILCAR SABINO; LINO-DOS-SANTOS-FRANCO, ADRIANA. Light-Emitting Diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin. Journal of Biophotonics, v. 10, n. 12, SI, p. 1683-1693, . (15/08041-3, 15/00830-9)

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