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Biochemical, physiological and functional genomic studies of Leishmania-macrophage interaction

Grant number: 14/50717-1
Support Opportunities:Research Projects - Thematic Grants
Duration: June 01, 2015 - May 31, 2019
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Lucile Maria Floeter-Winter
Grantee:Lucile Maria Floeter-Winter
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The biology of parasites belonging to Leishmania genus offers unique features as model for studying the host - pathogen interaction. Here we propose three sub-projects to study biochemical and physiological aspects of this interaction, primarily upon infe (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. The impact of arginase activity on virulence factors of Leishmania amazonensis. Current Opinion in Microbiology, v. 52, p. 110-115, . (17/23933-3, 14/50717-1, 16/03273-6, 16/19815-2)
ACUNA, STEPHANIE MAIA; ZANATTA, JONATHAN MIGUEL; DE ALMEIDA BENTO, CAMILLA; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. iR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensi. ON-CODING RN, v. 8, n. 1, . (18/24693-9, 19/07089-3, 18/18499-5, 17/23519-2, 14/50717-1)
MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism. SCIENTIFIC REPORTS, v. 7, . (14/50717-1, 10/52688-8, 14/20809-1, 12/15263-4)
AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; ZAMPIERI, RICARDO ANDRADE; LARANJEIRA-SILVA, MARIA FERNANDA; MULLER, KARL ERIK; NERLAND, AUDUN HELGE; FLOETER-WINTER, LUCILE MARIA. RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginasedependent gene expression regulation. PLoS Neglected Tropical Diseases, v. 11, n. 10, . (14/50717-1)
MUXEL, SANDRA M.; AOKI, JULIANA I.; FERNANDES, JULIANE C. R.; LARANJEIRA-SILVA, MARIA F.; ZAMPIERI, RICARDO A.; ACUNA, STEPHANIE M.; MULLER, KARL E.; VANDERLINDE, RUBIA H.; FLOETER-WINTER, LUCILE M.. Arginine and Polyamines Fate in Leishmania Infection. FRONTIERS IN MICROBIOLOGY, v. 8, . (16/22896-4, 14/50717-1, 15/25942-4, 16/19815-2)
MUXEL, SANDRA MARCIA; ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages. FRONTIERS IN IMMUNOLOGY, v. 9, . (16/03273-6, 17/23519-2, 14/20809-1, 14/50717-1, 16/19815-2)
ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; RIBEIRO FERNANDES, JULIANE CRISTINA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis. PLoS One, v. 12, n. 11, . (14/50717-1, 15/25942-4, 16/19815-2)
AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; ZAMPIERI, RICARDO ANDRADE; ACUNA, STEPHANIE MAIA; RIBEIRO FERNANDES, JULIANE CRISTINA; VANDERLINDE, RUBIA HELOISA; OLIVEIRA DE PINHO SALES, MARIA CARMEN; FLOETER-WINTER, LUCILE MARIA. L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis. PLoS Neglected Tropical Diseases, v. 11, n. 10, . (14/50717-1)
MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; CARVALHO-SOUSA, CLAUDIA EMANUELLE; FLOETER-WINTER, LUCILE MARIA; MARKUS, REGINA P.. The RelA/cRel nuclear factor-B (NF-B) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages. Journal of Pineal Research, v. 60, n. 4, p. 394-404, . (14/50717-1, 10/52688-8, 13/13691-1, 12/15263-4)
RIBEIRO FERNANDES, JULIANE CRISTINA; AOKI, JULIANA IDE; ACUNA, STEPHANIE MAIA; ZAMPIERI, RICARDO ANDRADE; MARKUS, REGINA P.; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 9, . (16/19815-2, 16/03273-6, 12/15263-4, 14/50717-1, 17/23519-2)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.