Advanced search
Start date

Study of natural compounds with antifungal activity to elucidate the action mechanism

Grant number: 14/23841-3
Support Opportunities:Regular Research Grants
Duration: March 01, 2015 - April 30, 2017
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Ana Lucia Fachin Saltoratto
Grantee:Ana Lucia Fachin Saltoratto
Host Institution: Universidade de Ribeirão Preto (UNAERP). Campus Ribeirão Preto. Ribeirão Preto , SP, Brazil
Associated researchers:Mozart de Azevedo Marins


Trichophyton rubrum (T. rubrum) is the main etiological agent of dermatophytosis in the world. Despite the increased incidence of fungal infections, there are few drugs on the market and their targets are limited because of cell similarities shared between fungi and mammalian. The search for new antifungals of natural origin with new targets is increasing due to an increase in the frequency of infectious diseases, as well as multiple drug resistance (MDR). The objective of this project is to evaluate the antifungal activity against T.rubrum of some natural products: trans chalcone, licochalcone, apigenin, itaconic acid, rosmarinic acid, caffeic acid (the active product of propolis), and purified glycoalkaloids of Solanum lycocarpum. Thereafter, we have the prospect to elucidate the mechanisms of action of compounds that showed potential biological activity using molecular (gene expression by microarray, real time PCR or array) and cellular assays (morphologic changes in membrane damage, quantification of ergosterol and protoplast regeneration). (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BITENCOURT, TAMIRES APARECIDA; MACEDO, CLAUDIA; FRANCO, MATHEUS ELOY; ASSIS, AMANDA FREIRE; KOMOTO, TATIANA TAKAHASI; STEHLING, ELIANA GUEDES; BELEBONI, RENE OLIVEIRA; MALAVAZI, IRAN; MARINS, MOZART; FACHIN, ANA LUCIA. Transcription profile of Trichophyton rubrum conidia grown on keratin reveals the induction of an adhesin-like protein gene with a tandem repeat pattern. BMC Genomics, v. 17, . (14/23841-3, 12/02920-7, 12/03845-9)
FRANCO, MATHEUS ELOY; BITENCOURT, TAMIRES APARECIDA; MARINS, MOZART; FACHIN, ANA LUCIA. In silico characterization of tandem repeats in Trichophyton rubrum and related dermatophytes provides new insights into their role in pathogenesis. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, . (12/03845-9, 14/23841-3, 12/02920-7)
MICHELOTTO CANTELLI, BRUNA ALINE; BITENCOURT, TAMIRES APARECIDA; KOMOTO, TATIANA TAKAHASI; BELEBONI, RENE OLIVEIRA; MARINS, MOZART; FACHIN, ANA LUCIA. Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum. BIOMEDICINE & PHARMACOTHERAPY, v. 96, p. 1389-1394, . (16/22701-9, 15/23435-8, 14/23841-3)

Please report errors in scientific publications list by writing to: