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Sleep-related movement disorders: interfaces between physical exercise and iron metabolism

Grant number: 14/19212-0
Support Opportunities:Regular Research Grants
Duration: March 01, 2015 - February 28, 2018
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Andrea Maculano Esteves
Grantee:Andrea Maculano Esteves
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated researchers:Adriana Souza Torsoni ; Fúlvia de Barros Manchado Gobatto


The Restless Legs Syndrome (RLS) is a multifactorial disorder, where nearly one third of their cases is secondary to other conditions, such as pregnancy. Research has shown that the risk factors for the increased incidence of RLS in pregnant women include among others the anemia, since iron deficiency (DFe) during pregnancy can result in serious consequences for the mother and her baby. Furthermore, an increased risk of low birth weight, morbidity and mortality have been observed in newborns, there are also some long term sequelae such as cognitive deficits and behavioral changes. On the other hand, in the literature there is evidence that physical activity has neuroprotective properties which modulates different brain functions. Thus, the main objective of this study is to evaluate in pregnant rats and their offspring, the relationship between exercise and dietary iron (supplementation and restriction) in sleep-related parameters and locomotor activity as well as the involvement of the dopaminergic system after the practice of physical exercise in the offspring. In order to carry out this study pregnant Wistar rats will be divided into groups to receive control diet, supplementation and iron restriction during pregnancy and a test to evaluate the locomotor and behavioral functions will be performed at this time (Open Field).After weaning, the offspring of each group will be allocated in a group which will conduct exercise and while the other group will remain sedentary. Reviews of sleep (polysomnography), behavior, locomotor activity (Open Field) and analysis of gene expression, protein content of D2 receptor, DAT, TH and hepcidin will be performed after 8 weeks of physical training (swimming). In this context, it is important to observe how an external situation (exercise) can reverse changes in sleep patterns of offspring derived from manipulations performed in mothers (iron diet), since these new investigations will contribute to clarify the complex phenotype of RLS. (AU)

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