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Effects of ouabain in memory and in response to stress: influence of Na, K-ATPase in the modulation of NF-kB / CREB- Wnt -BDNF glucocorticoids and / corticotropin signaling cascades in the central nervous system

Grant number: 14/05026-0
Support Opportunities:Regular Research Grants
Duration: February 01, 2015 - January 31, 2017
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal Investigator:Cristoforo Scavone
Grantee:Cristoforo Scavone
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Elisa Mitiko Kawamoto Iwashe


Evidence has shown that OUA is release in a different time-course when compared to GC during a stress response. In addition, OUA also interferes with the CRH transport into the circulation indicating that this hormone plays an important role in the stress response. However, there is no data about the OUA effects during a chronic unpredictable stress. The present work aims to investigate the molecular effect of OUA treatment on the HPA axis of rats exposed to chronic unpredictable stress. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KINOSHITA, PAULA F.; YSHII, LIDIA M.; ORELLANA, ANA MARIA M.; PAIXAO, AMANDA G.; VASCONCELOS, ANDREA R.; LIMA, LARISSA DE SA; KAWAMOTO, ELISA M.; SCAVONE, CRISTOFORO. Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells. SCIENTIFIC REPORTS, v. 7, . (11/22844-0, 11/10303-5, 14/05026-0, 16/07376-4, 11/21308-8, 11/12255-8, 11/04327-9)

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