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Understanding effective anti-parasite immunity and parasitism with lymph cannulation and genomics: towards better control options

Grant number: 14/50269-9
Support Opportunities:Regular Research Grants
Duration: October 01, 2014 - September 30, 2016
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Convênio/Acordo: University of Melbourne
Principal Investigator:Isabel Kinney Ferreira de Miranda Santos
Grantee:Isabel Kinney Ferreira de Miranda Santos
Principal researcher abroad: Jean-Pierre Scheerlinck
Institution abroad: University of Melbourne, Australia
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:12/50814-1 - Defining the genetic and semiochemical basis of tick resistance in cattle, AP.R


Vaccines are a sustainable means to control endo and ectoparasites, but their development requires knowledge about components and induction of protective immunity and on mechanisms of parasitism. Acquisition of useful knowledge would benefit from techniques to access lymph draining the host's target organs of infections and from improved functional annotation of parasite transcriptomes. São Paulo (SP) scientists have experience in studying immunity to ticks in ruminants with traditional methods and with functional genomics of ticks and hosts. In order to better describe local immunity University of Melbourne (UM) scientists developed in ruminants a method to access the lymph that drains areas of immune reactions to parasites. They also study functional genomics of parasitic worms-Ticks and worms cause important problems in livestock in Brazil and Australia. This project will deepen understanding of mechanisms of resistance of hosts to ticks and mechanisms of parasitism. UM scientists will train SP scientists in lymph cannulalion technique using the SEI model of artificial tick infestations in bovines. UM and SP scientists will compare bioinformatics and functional annotation procedures of their existing tick and worm transcriptomes (bioinformatic pipelines and databases developed by UM scientists and pipelines used by SP scientists through a collaboration with NIH) and possibly identify common and tick- and worm-restricted mediators of parasitism. (AU)

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