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New functional aspects of eicosanoids

Grant number: 14/07125-6
Support Opportunities:Research Projects - Thematic Grants
Duration: December 01, 2014 - February 28, 2021
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Lúcia Helena Faccioli
Grantee:Lúcia Helena Faccioli
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Carlos Arterio Sorgi ; Celio Lopes Silva ; Elaine Aparecida Del Bel Belluz Guimarães ; Eliane Candiani Arantes Braga ; Fabiani Gai Frantz ; Francisco Wanderley Garcia de Paula e Silva ; José Carlos Farias Alves Filho ; Luiz Alberto Beraldo de Moraes
Associated grant(s):20/05207-6 - Prospective evaluation of lipid mediators production on the immune response against COVID-19: search for biomarkers and new therapeutic targets in the evolution of the disease, AP.R
18/06230-1 - 6th Annual Meeting of the International Cytokine and Interferon Society, AR.EXT
17/01765-1 - Cell Symposia: Cancer, Inflammation and Immunity, AR.EXT
15/00658-1 - New functional aspects of eicosanoids, AP.EMU
Associated scholarship(s):18/25704-4 - Lipid analysis using ion mobility spectrometry (DMS) for determination of lipid profile in scorpions and snakes venom, BP.PD
18/10929-0 - The role of CD14 receptor on the metabolic regulation of macrophages stimulated with the venom from Tityus serrulatus scorpion, BP.MS
17/02314-3 - Investigation of cardiac changes that occur in poisoning by Tityus serrulatus scorpion venom, BP.DR
 + associated scholarships 16/22899-3 - Effect of the murine melanoma tumor microenvironment metabolites on macrophages lipid metabolism modulation, BP.IC
16/16788-4 - Simultaneous identification and quantification of cytochrome-P450 pathway (CYP450)-derived eicosanoids using high performance liquid chromatography coupled to sequential mass spectrometry (HPLC-MS/MS), BP.PD
15/19975-7 - Formation of lipid corpuscles and production of eicosanoids in macrophages derived from bone marrow activated by the classic/alternative pathway, associated with tumors, BP.IC
15/18824-5 - Qualitative and quantitative analysis of platelet activator factor (PAF) in human plasma, employing high-performance liquid chromatography coupled to sequential mass spectrometry (HPLCMS /MS), BP.IC
15/18872-0 - Tityus serrulatus scorpion venom effects on inflammatory mediators production by human lineage monocytes, BP.IC - associated scholarships

Abstract

In recent years new functions of EICs have been described, but much still needs to be researched on these lipids. This Thematic project aims to explore new aspects of EICs in six distinct and innovative subprojects. We will investigate the production and functions of EICs in five of them: (i) Investigation of the involvement of eicosanoids in chronic unpredictable stress-induced depression; (ii) Profile of macrophages, eicosanoid metabolism and tumor-associated activity; (iii) Relationship between activation of the inflammasome, production of lipid mediators, lung inflammation and death induced by scorpion venom; (iv) Involvement of aryl hydrocarbon receptor in the polarization of Treg, Th17 and Th22 cells and eicosanoids production in Histoplasma capsulatum infection; (v) Evaluation of the involvement of 5-lipoxygenase metabolites in Achromobacter xylosoxidans pulmonary infection. The last, (vi) Eicosanoid lipidomics from leukocytes of healthy individuals, aims to determine values of EICs production by leukocytes of healthy subjects for future comparison of production by patient's cells. This Thematic will be carried out by a multidisciplinary, multi-institutional and transnational team, with confirmed competency in different areas of the subproject, linked by a common topic, which is the study of new functional aspects of EICs. Moreover, we intend to establish a core reference for identification of EICs, by mass spectrometry. (AU)

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Scientific publications (43)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; ZOCCAL, KARINA FURLANI; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDA GOBBI; PEIGNEUR, STEVE; VRIENS, KIM; THEVISSEN, KARIN; ANGELO CAMMUE, BRUNO PHILIPPE; et al. Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors. Peptides, v. 82, p. 44-51, . (13/21342-7, 14/03332-7, 12/13590-8, 13/06380-0, 14/07125-6, 13/21329-0, 11/12317-3)
PEREIRA, PRISCILLA A. T.; ASSIS, PATRICIA A.; PRADO, MORGANA K. B.; RAMOS, SIMONE G.; ARONOFF, DAVID M.; DE PAULA-SILVA, FRANCISCO W. G.; SORGI, CARLOS A.; FACCIOLI, LUCIA H.. Prostaglandins D-2 and E-2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum. Journal of Lipid Research, v. 59, n. 2, p. 195-206, . (09/07169-5, 14/07125-6)
ZOCCAL, KARINA F.; SORGI, CARLOS A.; HORI, JULIANA I.; PAULA-SILVA, FRANCISCO W. G.; ARANTES, ELIANE C.; SEREZANI, CARLOS H.; ZAMBONI, DARIO S.; FACCIOLI, LUCIA H.. Opposing roles of LTB4 and PGE(2) in regulating the inflammasome-dependent scorpion venom-induced mortality. NATURE COMMUNICATIONS, v. 7, . (14/07125-6, 11/51023-5, 14/03332-7, 14/04684-4)
FERRANTI PETI, ANA PAULA; LOCACHEVIC, GISELE APARECIDA; BORGES PRADO, MORGANA KELLY; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. High-resolution multiple reaction monitoring method for quantification of steroidal hormones in plasma. Journal of Mass Spectrometry, v. 53, n. 5, p. 423-431, . (14/07125-6, 16/16788-4, 15/00658-1)
DOS REIS, MOUZARLLEM BARROS; FACCIOLI, LUCIA HELENA. CARDIAC DYSFUNCTION INDUCED BY SCORPION ENVENOMATION IS MEDIATED BY NLRP3-INDUCED ACUTE MYOCARDITIS. Toxicon, v. 168, p. 1-pg., . (17/02314-3, 15/00658-1, 14/07125-6)
ZOCCAL, KARINA F.; GARDINASSI, LUIZ G.; BORDON, KARLA C. F.; ARANTES, ELIANE C.; MARLEAU, SYLVIE; ONG, HUY; FACCIOLI, LUCIA H.. EP80317 Restrains Inflammation and Mortality Caused by Scorpion Envenomation in Mice. FRONTIERS IN PHARMACOLOGY, v. 10, . (14/07125-6, 14/03332-7, 15/00658-1)
BERNARDI, DANIELA S.; BITENCOURT, CLAUDIA; DA SILVEIRA, DENISE S. C.; DA CRUZ, ESTAEL L. C. M.; PEREIRA-DA-SILVA, MARCELO A.; FACCIOLI, LUCIA HELENA; LOPEZ, RENATA F. V.. Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles. Nanomedicine-Nanotechnology Biology and Medicine, v. 12, n. 8, p. 2439-2448, . (12/05177-3, 14/07125-6, 11/13307-1, 14/22451-7)
ACUNHA, TANIZE; NARDINI, VIVIANI; FERRANTI PETI, ANA PAULA; BORGES PRADO, MORGANA KELLY; BERALDO MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Targeted analysis of eicosanoids derived from cytochrome P450 pathway by high-resolution multiple-reaction monitoring mass spectrometry. Journal of Mass Spectrometry, v. 56, n. 7, . (16/16788-4, 15/00658-1, 14/07125-6, 18/25704-4)
DOS SANTOS, RAFAELA SILVA; SORGI, CARLOS ARTERIO; FERRANTI PETI, ANA PAULA; VERAS, FLAVIO PROTASIO; FACCIOLI, LUCIA HELENA; GALDINO, GIOVANE. Involvement of Spinal Cannabinoid CB2 Receptors in Exercise-Induced Antinociception. Neuroscience, v. 418, p. 177-188, . (14/07125-6, 15/00658-1)
LOUREIRO, LUMA DA COSTA; LOUREIRO, LUANA DA COSTA; GABRIEL-JUNIOR, EDSON ALVES; ZAMBUZI, FABIANA ALBANI; FONTANARI, CAROLINE; SALES-CAMPOS, HELIOSWILTON; FRANTZ, FABIANI GAI; FACCIOLI, LUCIA HELENA; SORGI, CARLOS ARTERIO. Pulmonary surfactant phosphatidylcholines induce immunological adaptation of alveolar macrophages. Molecular Immunology, v. 122, p. 163-172, . (18/15066-0, 14/07125-6, 15/00658-1)
PRADO, MORGANA K. B.; FONTANARI, CAROLINE; SOUZA, CAMILA O. S.; GARDINASSI, LUIZ G.; ZOCCAL, KARINA F.; DE PAULA-SILVA, FRANCISCO W. G.; PETI, ANA P. F.; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; RAMOS, SIMONE G.; et al. IL-22 Promotes IFN-gamma-Mediated Immunity against Histoplasma capsulatum Infection. BIOMOLECULES, v. 10, n. 6, . (13/08216-2, 14/07125-6, 15/00658-1)
SOUZA, CAMILA O. S.; ESPINDOLA, MILENA S.; FONTANARI, CAROLINE; PRADO, MORGANA K. B.; FRANTZ, FABIANI G.; RODRIGUES, VANDERLEI; GARDINASSI, LUIZ G.; FACCIOLI, LUCIA H.. CD18 Regulates Monocyte Hematopoiesis and Promotes Resistance to Experimental Schistosomiasis. FRONTIERS IN IMMUNOLOGY, v. 9, . (14/07125-6, 15/00658-1)
REIS, MOUZARLLEM B.; ELIAS-OLIVEIRA, JEFFERSON; PASTORE, MARCELLA R.; RAMOS, SIMONE G.; GARDINASSI, LUIZ G.; FACCIOLI, LUCIA H.. Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation. TOXINS, v. 12, n. 3, . (17/02314-3, 14/07125-6)
REIS, MOUZARLLEM BARROS; ZOCCAL, KARINA FURLANI; GARDINASSI, LUIZ GUSTAVO; FACCIOLI, LUCIA HELENA. Scorpion envenomation and inflammation: Beyond neurotoxic effects. Toxicon, v. 167, p. 174-179, . (17/02314-3, 14/07125-6)
ACUNHA, TANIZE; ROCHA, BRUNO ALVES; NARDINI, VIVIANI; BARBOSA JR, FERNANDO; FACCIOLI, LUCIA HELENA. Lipidomic profiling of the Brazilian yellow scorpion venom: new insights into inflammatory responses following Tityus serrulatus envenomation. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 86, n. 9, p. 13-pg., . (15/00658-1, 21/03633-0, 18/24069-3, 14/07125-6, 22/07979-1, 18/25704-4)
SOUZA, CAMILA OLIVEIRA SILVA; GARDINASSI, LUIZ GUSTAVO; RODRIGUES, VANDERLEI; FACCIOLI, LUCIA HELENA. Monocyte and Macrophage-Mediated Pathology and Protective Immunity During Schistosomiasis. FRONTIERS IN MICROBIOLOGY, v. 11, . (14/07125-6, 18/22667-0)
ACUNHA, TANIZE; NARDINI, VIVIANI; FACCIOLI, LUCIA HELENA. A lipidomics approach reveals new insights intoCrotalus durissus terrificusandBothrops moojenisnake venoms. ARCHIVES OF TOXICOLOGY, v. 95, n. 1, . (15/00658-1, 14/07125-6, 18/25704-4)
FRANCINE LORENCETTI-SILVA; MAYA FERNANDA MANFRIN ARNEZ; JOÃO PEDRO DE QUEIROZ THOMÉ; MARCIO SANTOS DE CARVALHO; FABRÍCIO KITAZONO DE CARVALHO; ALEXANDRA MUSSOLINO DE QUEIROZ; LÚCIA HELENA FACCIOLI; FRANCISCO WANDERLEY GARCIA PAULA-SILVA. Leukotriene B4 Loaded in Microspheres Inhibits Osteoclast Differentiation and Activation. Brazilian Dental Journal, v. 33, n. 5, p. 35-45, . (14/14015-2, 14/07125-6)
FUZO, CARLOS A.; FRAGA-SILVA, THAIS F. C.; MARUYAMA, SANDRA R.; BASTOS, VICTOR A. F.; ROGERIO, LUANA A.; TAKAMIYA, NAYORE T.; DA SILVA-NETO, PEDRO V.; PIMENTEL, VINICIUS E.; TORO, DIANA M.; PEREZ, MALENA M.; et al. The turning point of COVID-19 severity is associated with a unique circulating neutrophil gene signature. IMMUNOLOGY, v. 169, n. 3, p. 21-pg., . (15/00658-1, 21/04590-3, 20/08534-8, 20/05207-6, 19/09881-6, 14/07125-6, 20/05270-0, 17/16328-6)
DA SILVA-NETO, PEDRO, V; DO VALLE, VALERIA B.; FUZO, CARLOS A.; FERNANDES, TALITA M.; TORO, DIANA M.; FRAGA-SILVA, THAIS F. C.; BASILE, PATRICIA A.; DE CARVALHO, JONATAN C. S.; PIMENTEL, VINICIUS E.; PEREZ, MALENA M.; et al. Matrix Metalloproteinases on Severe COVID-19 Lung Disease Pathogenesis: Cooperative Actions of MMP-8/MMP-2 Axis on Immune Response through HLA-G Shedding and Oxidative Stress. BIOMOLECULES, v. 12, n. 5, p. 20-pg., . (14/07125-6, 20/08534-8, 20/05270-0, 14/23946-0, 21/04590-3, 20/05207-6)
GONCALVES, JULIANA DE LIMA; ALVES DUARTE, ANA CAROLINE; ALMEIDA-JUNIOR, LUCIANO APARECIDO; DE CARVALHO, FABRICIO KITAZONO; DE QUEIROZ, ALEXANDRA MUSSOLINO; MANFRIN ARNEZ, MAYA FERNANDA; FACCIOLI, LUCIA HELENA; GARCIA PAULA-SILVA, FRANCISCO WANDERLEY. Enamel biomineralization under the effects of indomethacin and celecoxib non-steroidal anti-inflammatory drugs. SCIENTIFIC REPORTS, v. 12, n. 1, p. 13-pg., . (14/07125-6, 10/17611-4, 21/09272-0)
DA COSTA, ADELIANE C.; DE RESENDE, DANILO P.; SANTOS, BRUNO DE P. O.; ZOCCAL, KARINA F.; FACCIOLI, LUCIA H.; KIPNIS, ANDRE; JUNQUEIRA-KIPNIS, ANA P.. Modulation of Macrophage Responses by CMX, a Fusion Protein Composed of Ag85c, MPT51, and HspX from Mycobacterium tuberculosis. FRONTIERS IN MICROBIOLOGY, v. 8, . (14/07125-6)
ZOCCAL, KARINA F.; FERREIRA, GIOVANA Z.; PRADO, MORGANA K. B.; GARDINASSI, LUIZ G.; SAMPAIO, V, SUELY; FACCIOLI, LUCIA H.. LTB4 and PGE(2) modulate the release of MIP-1 alpha and IL-1 beta by cells stimulated with Bothrops snake venoms. Toxicon, v. 150, p. 289-296, . (15/18872-0, 14/07125-6, 14/03332-7)
PEREIRA, PRISCILLA A. T.; BITENCOURT, CLAUDIA S.; REIS, MOUZARLLEM B.; FRANTZ, FABIANI G.; SORGI, CARLOS A.; SOUZA, CAMILA O. S.; SILVA, CELIO L.; GARDINASSI, LUIZ G.; FACCIOLI, LUCIA H.. Immunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation. Inflammation Research, v. 69, n. 1, . (07/04741-4, 14/07125-6, 09/07169-5, 15/00658-1)
WIEZEL, GISELE A.; RUSTIGUEL, JOANE K.; MORGENSTERN, DAVID; ZOCCAL, KARINA E.; FACCIOLI, LUCIA H.; CRISTINA NONATO, M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom. Biochimie, v. 163, p. 33-49, . (14/03332-7, 11/23236-4, 15/24010-0, 14/23285-3, 14/06170-8, 14/07125-6)
SORGI, CARLOS ARTERIO; FERRANTI PETI, ANA PAULA; PETTA, TANIA; GALVAO MEIRELLES, ALYNE FAVERO; FONTANARI, CAROLINE; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. SCIENTIFIC DATA, v. 5, . (14/07125-6, 16/16788-4, 15/00658-1)
GALVAO, ALYNE FAVERO; PETTA, TANIA; FLAMAND, NICOLAS; BOLLELA, VALDES ROBERTO; SILVA, CELIO LOPES; JARDULI, LUCIANA RIBEIRO; RIBEIRO MALMEGRIM, KELEN CRISTINA; SIMOES, BELINDA PINTO; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 408, n. 13, p. 3613-3623, . (14/07125-6)
SOUZA, CAMILA O. S.; ELIAS-OLIVEIRA, JEFFERSON; PASTORE, MARCELLA R. R.; FONTANARI, CAROLINE; RODRIGUES, VANESSA F. F.; RODRIGUEZ, VANDERLEI; GARDINASSI, LUIZ G. G.; FACCIOLI, LUCIA H.. CD18 controls the development and activation of monocyte-to-macrophage axis during chronic schistosomiasis. FRONTIERS IN IMMUNOLOGY, v. 13, p. 13-pg., . (14/07125-6, 18/22667-0)
ELIAS-OLIVEIRA, JEFFERSON; BORGES PRADO, MORGANA KELLY; SILVA SOUZA, CAMILA OLIVEIRA; PASTORE, MARCELLA ROVERATO; RAMOS, SIMONE GUSMAO; COSTA DARINI, ANA LUCIA; GARDINASSI, LUIZ GUSTAVO; FACCIOLI, LUCIA HELENA. CD14 signaling mediates lung immunopathology and mice mortality induced by Achromobacter xylosoxidans. Inflammation Research, v. 71, n. 12, p. 12-pg., . (14/07125-6)
DE ARAUJO MOREIRA, MIRELLA DOS REIS; SALES-CAMPOS, HELIOSWILTON; FONTANARI, CAROLINE; GALVAO MEIRELES, ALYNE FAVERO; BORGES PRADO, MORGANA KELLY; ZOCCAL, KARINA FURLANI; SORGI, CARLOS ARTERIO; DA SILVA, CRISTIANE TEFE; GROPPO, MILTON; FACCIOLI, LUCIA HELENA. The ethanolic extract of Terminalia argentea Mart. & Zucc. bark reduces the inflammation through the modulation of cytokines and nitric oxide mediated by the downregulation of NF-kappa B. Journal of Ethnopharmacology, v. 261, . (14/03332-7, 14/07125-6)
DE CARVALHO, JONATAN C. S.; DA SILVA-NETO, PEDRO V.; TORO, DIANA M.; FUZO, CARLOS A.; NARDINI, VIVIANI; PIMENTEL, VINICIUS E.; PEREZ, MALENA M.; FRAGA-SILVA, THAIS F. C.; OLIVEIRA, CAMILLA N. S.; DEGIOVANI, AUGUSTO M.; et al. The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19. Viruses-Basel, v. 15, n. 2, p. 22-pg., . (15/00658-1, 21/04590-3, 20/08534-8, 20/05207-6, 14/07125-6, 22/07287-2, 20/05270-0)
SANTOS-LOBATO, BRUNO L.; GARDINASSI, LUIZ GUSTAVO; BORTOLANZA, MARIZA; PETI, ANA PAULA FERRANTI; PIMENTEL, ANGELA V.; FACCIOLI, LUCIA HELENA; DEL-BEL, ELAINE A.; TUMAS, VITOR. etabolic Profile in Plasma AND CSF of LEVODOPA-induced Dyskinesia in Parkinson's Disease: Focus on Neuroinflammatio. Molecular Neurobiology, v. 59, n. 2, . (14/07125-6, 12/17626-7)
DE MACEDO, LUANA HENRIQUE; SOUZA, CAMILA OLIVEIRA SILVA; GARDINASSI, LUIZ GUSTAVO; FACCIOLI, LUCIA HELENA. CD14 regulates the metabolomic profiles of distinct macrophage subsets under steady and activated states. Immunobiology, v. 227, n. 2, p. 10-pg., . (14/07125-6, 18/10929-0, 15/00658-1, 18/22667-0)
PETEAN, IGOR BASSI FERREIRA; SILVA-SOUSA, ALICE CORREA; DA SILVA, RAQUEL ASSED BEZERRA; LUCISANO, MARILIA PACIFICO; DA SILVA, LEA ASSED BEZERRA; DE CASTRO, GUILHERME PIEDADE ASSED; SOUSA-NETO, MANOEL DAMIAO; FACCIOLI, LUCIA HELENA; PAULA-SILVA, FRANCISCO WANDERLEY GARCIA. Systemic inhibition of 5-lipoxygenase by MK-886 exacerbates apical periodontitis bone loss in a mouse model. BMC ORAL HEALTH, v. 23, n. 1, p. 9-pg., . (14/07125-6, 10/17611-4, 13/09595-7)
REIS, MOUZARLLEM BARROS; TARTARI PEREIRA, PRISCILLA APARECIDA; CAETANO, GUILHERME FERREIRA; LEITE, MARCEL NANI; GALVAO, ALYNE FAVERO; GARCIA PAULA-SILVA, FRANCISCO WANDERLEY; CIPRIANI FRADE, MARCO ANDREY; FACCIOLI, LUCIA HELENA. Lipoxin A(4) encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. PLoS One, v. 12, n. 7, . (14/07125-6)
PRADO, MORGANA K. B.; LOCACHEVIC, GISELE A.; ZOCCAL, KARINA F.; PAULA-SILVA, FRANCISCO W. G.; FONTANARI, CAROLINE; FERREIRA, JOSEANE C.; PEREIRA, PRISCILLA A. T.; GARDINASSI, LUIZ G.; RAMOS, SIMONE G.; SORGI, CARLOS A.; et al. Leukotriene B-4 is essential for lung host defence and alpha-defensin-1 production during Achromobacter xylosoxidans infection. SCIENTIFIC REPORTS, v. 7, . (14/07125-6)
ZOCCAL, KARINA F.; GARDINASSI, LUIZ G.; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; BORDON, KARLA C. F.; GLEZER, ISAIAS; CUPO, PALMIRA; MATSUNO, ALESSANDRA K.; BOLLELA, VALDES R.; ARANTES, ELIANE C.; et al. CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1 beta Release and Inflammation. FRONTIERS IN IMMUNOLOGY, v. 9, . (13/07937-8, 14/07125-6, 15/00658-1, 14/03332-7)
SORGI, CARLOS A.; ZARINI, SIMONA; MARTIN, SARAH A.; SANCHEZ, RAPHAEL L.; SCANDIUZZI, RODRIGO F.; GIJON, MIGUEL A.; GUIJAS, CARLOS; FLAMAND, NICOLAS; MURPHY, ROBERT C.; FACCIOLI, LUCIA H.. Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. SCIENTIFIC REPORTS, v. 7, . (14/07125-6, 14/13127-1, 15/00658-1)
CERNI, FELIPE AUGUSTO; PUCCA, MANUELA BERTO; ZOCCAL, KARINA FURLANI; FRANTZ, FABIANI GAI; FACCIOLI, LUCIA HELENA; ARANTES, ELIANE CANDIANI. Expanding biological activities of Ts19 Frag-II toxin: Insights into IL-17 production. Toxicon, v. 134, p. 18-25, . (14/07125-6, 13/21329-0, 14/03332-7, 13/21342-7)
LORENCETTI-SILVA, FRANCINE; SALES, LARISSA STHEFANI; LAMARQUE, GIULIANA DE CAMPOS CHAVES; CAIXETA, GIOVANA AMORIM; ARNEZ, MAYA FERNANDA MANFRIN; FACCIOLI, LUCIA HELENA; PAULA-SILVA, FRANCISCO WANDERLEY GARCIA. Effects of inflammation in dental pulp cell differentiation and reparative response. FRONTIERS IN DENTAL MEDICINE, v. 3, p. 8-pg., . (14/07125-6, 19/00204-1)
DE OLIVEIRA, HERICK ULISSES; DOS SANTOS, RAFAELA SILVA; SILVA MALTA, IAGO HENRIQUE; PINHO, JOSE PHELLIPE; SANTOS ALMEIDA, ANA FLAVIA; SORGI, CARLOS ARTERIO; FERRANTI PETI, ANA PAULA; XAVIER, GABRIELA SANTOS; DOS REIS, LUCIANA MARIA; FACCIOLI, LUCIA HELENA; et al. Investigation of the Involvement of the Endocannabinoid System in TENS-Induced Antinociception. JOURNAL OF PAIN, v. 21, n. 7-8, p. 820-835, . (14/07125-6, 15/00658-1)
REIS, MOUZARLLEM B.; RODRIGUES, FERNANDA L.; LAUTHERBACH, NATALIA; KANASHIRO, ALEXANDRE; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; SILVA, CARLOS A. A.; ZOCCAL, KARINA F.; SOUZA, CAMILA O. S.; RAMOS, SIMONE G.; et al. Interleukin-1 receptor-induced PGE(2) production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation. NATURE COMMUNICATIONS, v. 11, n. 1, . (15/21976-1, 14/07125-6, 17/02314-3, 15/00658-1)
LOCACHEVIC, GISELE A.; PRADO, MORGANA K. B.; ZOCCAL, KARINA F.; PEREIRA, PRISCILLA A. T.; SORGI, CARLOS A.; BORTOLANZA, MARIZA; PETI, ANA PAULA F.; FOGACA, MANOELA V.; GUIMARAES, FRANCISCO S.; DEL BEL, ELAINE; et al. Paradoxical Effect of LTB4 on the Regulation of Stress-Induced Corticosterone Production. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 13, . (14/07125-6, 15/00658-1)

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