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Acyl-carnitines as markers of intermediate metabolism in morbidly obese individuals undergoing a clinical treatment for weight loss

Abstract

Obesity is involved in the development of diseases associated with disturbed lipid metabolism such as diabetes, dyslipidemia and cardiovascular disease. Excess lipids stimulate inflammation via activation of receptors such TLR4, leading to changes in insulin signaling. Furthermore, ectopic fat accumulation observed in obesity generates metabolites that can also interfere with intracellular signaling of insulin, such as ceramide, diacylglycerol and others. Increased oxidation of fatty acids would be an alternative to reduce the accumulation of these metabolites, reversing insulin resistance. There are several reports that carnitine supplementation is associated with increased insulin sensitivity. Carnitine plays multiple roles in fatty acid metabolism: it allows their import to mitochondria, acts as a buffer for free coenzyme A (CoA), allows the transfer of the peroxisomal ²-oxidation products to the mitochondria and the elimination of acyl groups when metabolism of these is deficient. Also, it is directly linked to metabolic flexibility, which is the body's ability to switch between the use of carbohydrates and lipids as an energy source because it prevents the accumulation of acetyl-CoA, which would otherwise inhibit glucose uptake via cycle Randle. This effect, coupled with the ability of the acyl-carnitines modulate the inflammatory process, makes carnitine and acyl-carnitines targets for understanding the mechanisms that lead to insulin resistance, and contribute to the development of obesity-related diseases. The central objective of this project is to look through these markers and monitor the oxidation of fatty acids in individuals with morbid obesity submitted to a clinical intervention for weight loss. Understanding the mechanisms of mobilization and oxidation of energy substrates can help in planning clinics or dietary interventions that support these processes and facilitate weight loss. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FIAMONCINI, JARLEI; BARBOSA, CARINA FERNANDES; ARNONI JUNIOR, JOSE RUBENS; ARAUJO JUNIOR, JOSE CELESTINO; TAGLIERI, CINTHIA; SZEGO, TIAGO; GELHAUS, BARBARA; DE SOUZA, HERALDO POSSOLO; DANIEL, HANNELORE; DE LIMA, THAIS MARTINS. Roux-en-Y Gastric Bypass Surgery Induces Distinct but Frequently Transient Effects on Acylcarnitine, Bile Acid and Phospholipid Levels. METABOLITES, v. 8, n. 4, . (14/05260-3)

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