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Identification and location of sex steroid receptors expression in the temporomandibular joints of rats

Grant number: 14/04617-5
Support Opportunities:Regular Research Grants
Duration: October 01, 2014 - September 30, 2016
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Edmund Chada Baracat
Grantee:Edmund Chada Baracat
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Edson Aparecido Liberti ; Matsuyoshi Mori


The temporomandibular dysfunction (TMD) comprises disorders in joint structures and/or muscles related to the temporomandibular joint (TMJ). Presents a high prevalence in females, suggesting a possible hormonal role, especially estrogens. Knowing that the hormonal action is dependent on the binding hormone to its receptor, several studies have attempted to identify these components in temporomandibular tissues, but their results were not conclusive. This project aims to determine the possible presence of estrogen, progesterone and testosterone receptors in male and female rats TMJ, as well as its location and expression. The females will be considered with regard to age, within the ranges corresponding to the peak reproductive, premenopausal and postmenopausal of the women. The males will have ages corresponding to these phases. Furthermore, as receptor expression may change under certain conditions, it will be analyzed regarding the TMJ load received during function, considering the different incidence areas. Statistical analysis will be performed using SPSS software version 20.0, by appropriate tests. (AU)

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