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Drug design, synthesis and biological evaluation of hibrids with potential activity on the Alzheimer's Disease treatment

Grant number: 14/14980-0
Support Opportunities:Regular Research Grants
Duration: October 01, 2014 - January 31, 2018
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal Investigator:Chung Man Chin
Grantee:Chung Man Chin
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated researchers:Jean Leandro dos Santos

Abstract

Alzheimer's disease (AD) is clearly the main and most common cause of senile dementia in the world contributing with 60-70% of diagnosed cases. Fourth leading cause of death in developed countries the DA is behind only cardiovascular disease, cancer and stroke. Worldwide, the prevalence of dementia is estimated at 3.9 % of people aged 60 or more. In developed countries, about one in ten elderly aged 65 years or more, has some degree of dementia, while more than a third of people considered to be very old, with more than 85 years, show some symptoms and signs of dementia. AD is a progressive brain disease, diagnosed patients show an extensive loss of synapses and neurons in the hippocampus and in the frontal and temporal cortices, which gradually compromises their memory, learning ability, reasoning, communication and activities of daily living. Currently there is no cure or treatment that can effectively modify the disease, the drugs available on the market (tacrine, donepezil, rivastigmine, galantamine and memantine) only reduce some symptoms manifested by patients. Thus, it is essential to develop new therapeutic approaches for obtaining new drugs that can slow or prevent disease progression. This work aims to obtain drug candidates with anti-inflammatory / neuroprotective properties, obtained by molecular hybridization strategy, where the inhibition of TNF-±, the stabilizing action of microtubules and donation of nitric oxide could reduce the process of neuroinflammation associated with deposition of senile plaques and neurofibrillary tangles, reducing oxidative stress and contributing to synaptic plasticity, cognition and memory, attenuating the effects associated with loss of neurons of patients affected by AD. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAVAN, ALINE RENATA; BERNARDES DA SILVA, GABRIEL DALIO; JORNADA, DANIELA HARTMANN; CHIBA, DIEGO EIDY; DOS SANTOS FERNANDES, GUILHERME FELIPE; CHIN, CHUNG MAN; DOS SANTOS, JEAN LEANDRO. Unraveling the Anticancer Effect of Curcumin and Resveratrol. NUTRIENTS, v. 8, n. 11, . (15/19531-1, 16/08470-4, 14/14980-0, 15/21252-3, 14/24811-0, 14/02240-1)
SCARIM, CAUE B.; DE ANDRADE, CLEVERTON R.; DA ROSA, JOAO A.; DOS SANTOS, JEAN L.; CHIN, CHUNG M.. Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study. International Journal of Experimental Pathology, v. 99, n. 5, p. 236-248, . (14/14980-0)
JORNADA, DANIELA HARTMANN; DOS SANTOS FERNANDES, GUILHERME FELIPE; CHIBA, DIEGO EIDY; FERREIRA DE MELO, THAIS REGINA; DOS SANTOS, JEAN LEANDRO; CHUNG, MAN CHIN. The Prodrug Approach: A Successful Tool for Improving Drug Solubility. Molecules, v. 21, n. 1, . (14/14980-0, 14/24811-0, 14/02240-1, 14/06755-6)

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