The crystallography as tool in the help to elucidate the mechanism of action of potential metallodrugs

Abstract

The present project aims the application of techniques for determination of structures by X-ray diffraction of monocrystals to study the bonds in complexes with general formulae [PtCl(PPh3)2(N`-(acyl)-N',N'-(di-substituted)thioureas-k2O,S)], cis-[Pd(PPh3)2(N`-(acyl)-N',N'- (di-substituted)thioureas-k2O,S)]PF6, trans-[Ru(PPh3)2(N`-(acyl)-N',N'-(di-substituted) thioureas-k2O,S)(bipy)]PF6. After the synthesis of the complexes with high purity (by Prof. Alzir Azevedo Batista´s group, Inorganic Chemistry Laboratory, UFSCAR), the cytotoxicity of the complexes against breast and prostate cancer cells, by colorimetric MTT method, the results will be compared with those of fibroblast cells, to make the screening for further study with respect the death mecanism of action and the interactions of the complexes with DNA. Knowing the molecular geometry of the complexes, and with the help of other techniques, such as NMR, UV-Vis, IR, there is a expectation to be possible to relate structure and activity of the complexes under study. (AU)