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Cortisol to cortisone: benefical conversion on birth stress and development of the lamb?

Grant number: 13/25004-9
Support Opportunities:Regular Research Grants
Duration: September 01, 2014 - August 31, 2016
Field of knowledge:Agronomical Sciences - Animal Husbandry - Ecology of Domestic Animals and Ethology
Principal Investigator:Cristiane Gonçalves Titto
Grantee:Cristiane Gonçalves Titto
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Associated researchers:Adroaldo Jose Zanella ; Alfredo Manuel Franco Pereira ; Evaldo Antonio Lencioni Titto

Abstract

The aim of the study is to assess the possible influence of gestational stress on maternal-filial relationship and performance of the lamb, as well as the stress of weaning on feedlot performance and carcass. There will also be the quantification of cortisol and cortisone in ewe and lamb to verify a possible presence of the enzyme 11beta-HSD and its effect on stress. The experiment will run on sheep and goad sector, Faculty of Animal Science and Food Engineering from the University of São Paulo in Pirassununga, Brazil. It will be used 60 crossbred females breed Santa Ines, that after artificially fertilized with sperm of Santa Ines males will be randomly allocated into six treatments: The experiment will be randomized (DIC) having a 3 x 2 factorial scheme as the distribution of treatments with 3 groups (control (GC), application of LPS at 70 days of gestation (GI), and at 120 days of gestation (GF)) combining with 2 types weaning (abrupt weaning (Da) and weaning controlled (Dc)). We will analyze the levels of cortisol and cortisone in saliva, IgA, IgG, IgM, IL-1, IL-6, TNFalpha in blood samples and its influence on maternal-filial behavior and performance of lambs considering birth weight (PN), weaning weight (PD), dry matter intake (CMS), feed conversion (CA), feed efficiency (EA), average daily gain (GMD) and carcass yield (RC). It will also be carried out RNA sequencing to find the target genes 11b-HSD 1 and 2 in the placenta. The analysis will be performed using the PROC MIXED of SAS. For the maternal behavior analysis will branch to the theory of generalized linear model proposed by Wenderburn and Nelder (1972), using the SAS GLIMMIX's procedure. It is expected to find relationships between stress and performance at different life stages of the animal. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HENRIQUE, FABIO LUIS; LENCIONI TITTO, EVALDO ANTONIO; ZANELLA, ADORALDO JOSE; HOOPER, HENRIQUE BARBOSA; PULIDO-RODRIGUEZ, LINA FERNANDA; SILVA LONGO, ANA LUISA; DA CUNHA LEME-DOS-SANTOS, THAYS MAYRA; FRANCO PEREIRA, ALFREDO MANOEL; TITTO, CRISTIANE GONCALVES. Simulated disease process during late pregnancy compromises developmental outcomes of lambs independently of the weaning method applied. Small Ruminant Research, v. 155, p. 39-44, . (13/25004-9, 13/08180-8)
HENRIQUE, FABIO LUIS; TITTO, CRISTIANE GONCALVES; LENCIONI TITTO, EVALDO ANTONIO; HOOPER, HENRIQUE BARBOSA; PULIDO-RODRIGUEZ, LINA FERNANDA; SILVA LONGO, ANA LUISA; DA CUNHA LEME-DOS-SANTOS, THAYS MAYRA; GAMEIRO, AUGUSTO HAUBER; FRANCO PEREIRA, ALFREDO MANOEL; ZANELLA, ADROALDO JOSE. Abrupt weaning type combined to stress during late pregnancy in sheep present economic losses on carcass and low testicular development in lambs. JOURNAL OF ANIMAL BEHAVIOUR AND BIOMETEOROLOGY, v. 6, n. 2, p. 29-32, . (13/25004-9, 13/08180-8)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.