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Experimental evaluation of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw

Grant number: 14/10693-6
Support Opportunities:Regular Research Grants
Duration: August 01, 2014 - July 31, 2016
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Camila Lopes Cardoso
Grantee:Camila Lopes Cardoso
Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil


Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an oral complication in which clinical and experimental studies are required to elucidate its pathogenesis and treatment, although there are much scientific knowledge since its first report. There is no consensus regarding the best therapeutic approach of BRONJ showing satisfactory and predictable outcomes. The use of bone resection combined with platelet-rich plasma (PRP) is an alternative treatment modality which has shown satisfactory and promising outcomes in symptomatic cases. The aim of this study is to evaluate this alternative treatment in an experimental rat model. 32 rats will receive intravenous administration of zoledronic acid for induction of BRONJ. After the extraction of the right upper incisor and diagnosis of BRONJ, surgical treatment will be performed. In the experimental group, marginal resection of osteonecrosis will be performed followed by use of PRP. The control group will undergo the same procedures described for the experimental group, without PRP. After 14, 28 and 42 days, the animals will be euthanized and the evaluation will be done by quantitative analysis of new bone formation by computed microtomography. Moreover, morphological, morphometric and immunohistochemical microscopic analyses using VEGF and CD31 antibodies will be performed in order to assess microvascular density in the healing of the specimens. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CURRA, CLAUDIA; CARDOSO, CAMILA LOPES; FERREIRA JUNIOR, OSNY; CURI, MARCOS MARTINS; MATSUMOTO, MARIZA AKEMI; CAVENAGO, BRUNO CAVALINI; DOS SANTOS, PAMELA LETICIA; SANTIAGO JUNIOR, JOEL FERREIRA. Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model. Acta Cirurgica Brasileira, v. 31, n. 5, p. 308-313, . (14/10693-6)
CAMILA LOPES CARDOSO; CLÁUDIA CURRA; MARCOS MARTINS CURI; MARIZA AKEMI MATSUMOTO; CAMILA DIONÍSIO ARGENTINO; SOLANGE DE OLIVEIRA BRAGA FRANZOLIN; DULCE CONSTANTINO; DANIELA NICOLIELO BARBOSA; OSNY FERREIRA JÚNIOR. Treatment of bisphosphonate-related osteonecrosis using platelet-rich plasma: microtomographic, microscopic, and immunohistochemical analyses. Brazilian Oral Research, v. 33, . (14/10693-6)
SILVA, LARISSA FERNANDES; CURRA, CLAUDIA; MUNERATO, MARCELO SALLES; DEANTONI, CARLOS CESAR; MATSUMOTO, MARIZA AKEMI; CARDOSO, CAMILA LOPES; CURI, MARCOS MARTINS. Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review. ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG, v. 20, n. 1, p. 9-17, . (14/10693-6)

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