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Oxidative damage in salivary glands of rats in diabetes and chronic renal failure and possible benefits of supplementation of vitamins C and E

Grant number: 13/18609-1
Support Opportunities:Regular Research Grants
Duration: August 01, 2014 - July 31, 2016
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Fernando Neves Nogueira
Grantee:Fernando Neves Nogueira
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Cassia Marta de Toledo Bergamaschi


Saliva is a fluid produced and secreted from salivary glands whose importance in homeostasis of the individual is well known. Several diseases leads to reduction in the salivary flow or xerostomia, among them diabetes mellitus and chronic renal failure (CRF). In these systemic diseases we observed increase in the oxidative stress. Diabetes is a disease characterized by chronic hyperglycemia. In previous studies we demonstrated changes in the antioxidant system, increase of oxidative damage and alterations in the energetic potencial in salivary glands of diabetic rats. CRF is also a disease that affects great part of the world population where the increase of oxidative damage is present. Several studies demonstrated salivary alterations in patients with CRF, but few are those using the gland as a source of information. Antioxidant therapy with vitamins C and E reduces the oxidative stress presented in these diseases. The objectives of this study are: 1) analyze the presence of oxidative damages in rats with the model ablation of 5/6 renal mass 12 weeks after the surgery, as well changes in the energetic potential in submandibular (SM) and parotid (PA). 2) Verify possible benefits of the use of Vitamins C and E supplementations in the prevention of oxidative damages in diabetes and CRF. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, DOUGLAS NESADAL; DE SOUZA, EUGEN MENDES NESADAL; DA SILVA PEDROSA, MARLUS; NOGUEIRA, FERNANDO NEVES; SIMOES, ALYNE; NICOLAU, JOSE. Effect of Tungstate Administration on the Lipid Peroxidation and Antioxidant Parameters in Salivary Glands of STZ-Induced Diabetic Rats. BIOLOGICAL TRACE ELEMENT RESEARCH, v. 199, n. 4, . (13/18609-1)
CARVALHO, R. A.; ROMERO, A. C.; IBUKI, F. K.; NOGUEIRA, F. N.. Salivary gland metabolism in an animal model of chronic kidney disease. ARCHIVES OF ORAL BIOLOGY, v. 104, p. 40-45, . (13/18609-1)
NOGUEIRA, FERNANDO NEVES; ROMERO, ANA CAROLINA; PEDROSA, MARLUS DA SILVA; IBUKI, FLAVIA KAZUE; BERGAMASCHI, CASSIA TOLEDO. Oxidative stress and the antioxidant system in salivary glands of rats with experimental chronic kidney disease. ARCHIVES OF ORAL BIOLOGY, v. 113, . (13/18609-1)
IBUKI, FLAVIA KAZUE; BERGAMASCHI, CASSIA T.; PEDROSA, MARLUS DA SILVA; NOGUEIRA, FERNANDO NEVES. Effect of vitamin C and E on oxidative stress and antioxidant system in the salivary glands of STZ-induced diabetic rats. ARCHIVES OF ORAL BIOLOGY, v. 116, . (13/18609-1)

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